Parabacteroides goldsteinii has exhibited great potential to be a probiotic against obesity. Creative Biolabs here provides high-quality custom Parabacteroides goldsteinii-based probiotic development services for worldwide clients.
Parabacteroides goldsteinii (P. goldsteinii), also known as P. goldsteinii (Song et al. 2006) Sakamoto and Benno 2006, is a Gram-negative bacterium belonging to the genus of Parabacteroides and the family of Porphyromonadaceae. It was formerly named as Bacteroides goldsteinii, a human pathogen isolated from clinical intestinal specimens by Song et al. in 2005, and latterly reclassified as P. goldsteinii comb. nov. by Sakamoto et al. in 2006.
P. goldsteinii is a non-spore-forming and non-motile bacterium with rod-shaped and about 0.9-1.5 μm×1.2-10 μm in size. Colonies on the Brucella blood agar presents opaque gray round, slightly convex and smooth, with a diameter of 1~2 mm. P. goldsteinii is an obligately anaerobic species novel species principally distributing in human intestinal and feces.
Although P. goldsteinii was identified as a pathogen from individuals with clinical infections, its probiotic potential against obesity has been demonstrated in high-fat diet-induced obesity mice. During the study of anti-obesogenic effects of Hirsutella sinensis (H. sinensis), gut microbiota analysis found that the level of P. goldsteinii is significantly reduced in obesity mice, while is much higher in H. sinensis treated mice. Besides, further investigations indicated that:
Fig.2 Proposed model for the anti-obesogenic effects of Hirsutella sinensis mycelium and P. goldsteini in high-fat diet-fed mice. (Wu, 2018)
Probiotics-based live biotherapeutic has emerged as a novel, safe, and effective alternative for multiple disease treatment. As an experienced biotechnology company in innovative drug discovery, Creative Biolabs has invested numerous energy and efforts in the development of Next-Generation probiotics. In addition to P. goldsteini, we provide a variety of probiotic species development services for the treatment of related diseases based on:
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.