Parabacteroides goldsteinii as Next Generation Probiotics
Parabacteroides goldsteinii has exhibited great potential to be a probiotic against obesity. Creative Biolabs here provides high-quality custom Parabacteroides goldsteinii-based probiotic development services for worldwide clients.
Introduction to Parabacteroides goldsteinii
Parabacteroides goldsteinii (P. goldsteinii), also known as P. goldsteinii (Song et al. 2006) Sakamoto and Benno 2006, is a Gram-negative bacterium belonging to the genus of Parabacteroides and the family of Porphyromonadaceae. It was formerly named as Bacteroides goldsteinii, a human pathogen isolated from clinical intestinal specimens by Song et al. in 2005, and latterly reclassified as P. goldsteinii comb. nov. by Sakamoto et al. in 2006.
P. goldsteinii is a non-spore-forming and non-motile bacterium with rod-shaped and about 0.9-1.5 μm×1.2-10 μm in size. Colonies on the Brucella blood agar presents opaque gray round, slightly convex and smooth, with a diameter of 1~2 mm. P. goldsteinii is an obligately anaerobic species novel species principally distributing in human intestinal and feces.
Probiotic Potential of P. goldsteinii for Anti-Obesity
Although P. goldsteinii was identified as a pathogen from individuals with clinical infections, its probiotic potential against obesity has been demonstrated in high-fat diet-induced obesity mice. During the study of anti-obesogenic effects of Hirsutella sinensis (H. sinensis), gut microbiota analysis found that the level of P. goldsteinii is significantly reduced in obesity mice, while is much higher in H. sinensis treated mice. Besides, further investigations indicated that:
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Firstly, oral administration of live P. goldsteinii significantly reduced the weight gain and visceral fat, maintained intestinal integrity, and increased adipose tissue thermogenesis, exhibiting therapeutic effects on obesity and metabolic disorders in obesity mice model;
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Secondly, the live P. goldsteini treatment reduced endotoxemia and inflammation through inhibiting the mRNA expression of IL-1β and cell monolayer disruption, meanwhile, increasing the expression of IL-10 and ZO-1 in the colon;
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Thirdly, efficient transfer of P. goldsteinii by horizontal fecal microbiota transplantation also reduced insulin resistance and symptoms of nonalcoholic fatty liver disease in high-fat diet mice;
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Lastly and importantly, all these effective treatments by live P. goldsteini had no impact on liver or kidney functions.
Fig.2 Proposed model for the anti-obesogenic effects of Hirsutella sinensis mycelium and P. goldsteini in high-fat diet-fed mice. (Wu, 2018)
For Live Biotherapeutics Research, Choose Creative Biolabs!
Probiotics-based live biotherapeutic has emerged as a novel, safe, and effective alternative for multiple disease treatment. As an experienced biotechnology company in innovative drug discovery, Creative Biolabs has invested numerous energy and efforts in the development of Next-Generation probiotics. In addition to P. goldsteini, we provide a variety of probiotic species development services for the treatment of related diseases based on:
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Advanced and special-constructed Platform
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Highly experienced scientists and staff specialized in live biotherapeutics
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Highly customized service according to different research demand
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Streamlined services from consultation and project design, to on-time delivery and data interpretation
Please feel free to contact us and our experienced technicians will give you the most detailed answers to your questions.
References
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Wu, T.R., et al. Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. Gut. 2019, 68(2): 248-262.
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Song, Y., et al. "Bacteroides goldsteinii sp. nov." isolated from clinical specimens of human intestinal origin. Journal of clinical microbiology. 2005, 43(9): 4522-4527.
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