Parabacteroides goldsteinii Microbiome CRO Services

Creative Biolabs provides a science-first CRO service for teams advancing Parabacteroides goldsteinii programs—from strain sourcing to mechanistic validation and stability-ready formulations. Designed for microbiome innovators, biotech R&D, and translational academic groups, this offering delivers decision-grade datasets, reproducible production, and fit-for-purpose assays to de-risk early development.

A Proven CRO Partner for Probiotic R&D

Trusted by global R&D teams to generate rigorous, reproducible microbiome data and development-ready microbial materials.

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Why Develop P. goldsteinii with a Dedicated Microbiome CRO?

P. goldsteinii is an obligately anaerobic, Gram-negative member of the gut microbiome with strain-dependent functional signals that are highly sensitive to isolation conditions, passage history, media composition, and formulation stress. Those variables can quietly reshape phenotypes—especially when you move from discovery lots to reproducible batches.

Independent preclinical studies link specific P. goldsteinii strains to measurable biological outputs across metabolic, inflammatory, and gut–organ communication axes, making it a high-interest target for mechanism-driven microbiome programs. A CRO workflow becomes essential when you need controlled fermentation, standardized functional readouts, and safety-aligned documentation built around a single strain’s identity and performance.

P. goldsteinii microbiome services (Creative Biolabs Original)

Service Modules Tailored to P. goldsteinii Development

Microbial Isolation and Screening Services

Creative Biolabs supports P. goldsteinii isolation from complex samples using strict anaerobic workflows, selective conditions, and colony-level screening. Early filters prioritize growth robustness, consistency across passages, and phenotype retention—so candidate P. goldsteinii strains remain development-relevant instead of “one-off” isolates.

Microbial Identification Services

Accurate identification is foundational for P. goldsteinii programs. Our identification package confirms P. goldsteinii at genus/species level and strengthens traceability with strain-level documentation (e.g., sequencing-supported confirmation and banked records), minimizing downstream surprises from misassignment or mixed cultures.

Microbial Fermentation Services

P. goldsteinii fermentation is optimized under anaerobic control to balance biomass yield with functional stability. We tune media, pH trajectory, and harvest timing for consistent lots and scalable performance, generating P. goldsteinii materials appropriate for structured screening and preclinical research workflows.

Functional and MoA Screening

Creative Biolabs builds mechanism-focused screening plans for Parabacteroides goldsteinii, linking strain exposure to measurable outputs such as barrier-associated markers, inflammatory signaling modulation, and metabolite-linked pathways. This module is designed to convert “interesting taxonomy” into testable MoA hypotheses supported by clear endpoints.

In Vitro Tests of Immune System Modulation

For Parabacteroides goldsteinii, immune modulation readouts must be interpreted with careful controls because Gram-negative surface structures can drive context-specific responses. We evaluate cytokine/chemokine patterns, innate receptor-linked signaling panels, and inflammation-relevant markers to characterize how P. goldsteinii influences immune tone in vitro.

Biological Safety Test Services

Safety profiling for P. goldsteinii is approached as a data package, not a checkbox. Creative Biolabs supports biological safety testing aligned to research-stage decision making (identity, purity, contamination controls, and fit-for-purpose assessments), informed by published safety evaluation approaches used for P. goldsteinii strains.

Microbial Formulation Service

P. goldsteinii performance can shift after processing unless formulation is engineered intentionally. We develop protective matrices and handling strategies that preserve viability and functional attributes, while maintaining practical attributes such as dispersion behavior and storage compatibility for P. goldsteinii research applications.

Stability Test Service

Creative Biolabs offers stability and shelf-life assessment frameworks applicable to P. goldsteinii programs, including accelerated and real-time designs with stability-indicating analytics. This work supports evidence-based storage conditions, packaging decisions, and lot comparability across development stages.

Workflow for P. goldsteinii CRO Projects

1

Define Scientific Targets

Align P. goldsteinii endpoints, model systems, and success criteria with your development timeline.

2

Source and Qualify Strains

Select P. goldsteinii candidates, confirm identity, and establish controlled anaerobic handling procedures.

3

Build Reproducible Lots

Optimize P. goldsteinii cultivation and fermentation to generate consistent, documented research batches.

4

Run Functional Screens

Execute P. goldsteinii MoA assays and comparative screening with standardized controls and analytics.

5

Evaluate Safety and Quality

Apply P. goldsteinii safety-aligned tests, contamination checks, and release-style documentation for decisions.

6

Formulate and Stress-Test

Develop P. goldsteinii formulation and stability plans to protect function through storage and handling.

Service Advantages Built for Microbiome R&D Teams

Anaerobe-Ready Infrastructure

Strict anaerobic workflows protect P. goldsteinii integrity from isolation through downstream testing.

Strain-Level Traceability

Clear identity confirmation and documentation reduce ambiguity in P. goldsteinii multi-site collaborations.

MoA-Driven Assay Design

Mechanistic endpoints translate P. goldsteinii signals into interpretable, decision-grade datasets.

Development-Minded Fermentation

Process choices prioritize reproducibility for Parabacteroides goldsteinii, not just short-term growth success.

Stability-by-Design Thinking

Stress testing clarifies P. goldsteinii sensitivities early, avoiding late-stage reformulation cycles.

Collaborative Project Management

Creative Biolabs structures timelines and deliverables to keep P. goldsteinii programs moving efficiently.

Applications of P. goldsteinii in Research

Metabolic Disorders (Obesity & Diabetes)

Preclinical studies associate P. goldsteinii with reduced weight gain and adiposity, increased thermogenesis signatures, and improved glucose-handling markers in metabolic models—supporting mechanistic exploration around lipid metabolism and inflammatory tone.

Chronic Obstructive Pulmonary Disease

Via the gut–lung axis, P. goldsteinii has been reported to reduce inflammation-linked COPD features in smoke-exposed models; a strain-derived LPS was described as functionally antagonizing TLR4 signaling in that context.

Inflammatory Bowel Disease

Rodent colitis studies report that P. goldsteinii enrichment or administration can support barrier integrity markers and downshift pro-inflammatory signaling, including PI3K–Akt pathway involvement under DSS challenge conditions.

Liver Health (MASLD & AFLD)

Microbiome-focused literature highlights P. goldsteinii as a candidate organism of interest in metabolic liver disease research, including MASLD/MASH-relevant pathways in diet-driven models, motivating targeted metabolite and host-gene readouts.

Neurological & Neuropsychiatric Research

In maternal immune activation models, P. goldsteinii was linked to improved behavioral readouts and altered inflammation-related signatures; broader Parabacteroides literature also discusses neuroactive metabolites such as GABA in gut–brain studies.

Gastritis and Pathogen Antagonism

Work on P. goldsteinii MTS01 in Helicobacter pylori models reports shifts in pathogenesis-linked markers, including reduced virulence-factor expression (CagA/VacA) and modulation of cholesterol-related pathways, supporting non-antibiotic mechanistic exploration.

Sample submission form (Creative Biolabs Original)

Provide your sample, and we’ll design a goal-driven P. goldsteinii research plan.

P. goldsteinii Related Products

Explore our ready-to-order P. goldsteinii products to accelerate your study timelines and ensure experimental consistency.

Product Name Catalog No. Target Product Overview Size Price
Parabacteroides goldsteinii; Human abdominal fluid LBST-040FG Parabacteroides Parabacteroides goldsteinii was isolated from human abdominal fluid. It is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium. Inquiry
Parabacteroides goldsteinii; 63736 LBST-041FG Parabacteroides Parabacteroides goldsteinii was isolated from human. It is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium. Inquiry
Parabacteroides goldsteinii; 74546 LBST-042FG Parabacteroides Parabacteroides goldsteinii was isolated from human wound. It is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium. Inquiry
Parabacteroides goldsteinii LBST-043FG Parabacteroides Parabacteroides goldsteinii was isolated from caecal content. It is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium. Inquiry
Parabacteroides goldsteinii; 19448 LBST-044FG Parabacteroides Parabacteroides goldsteinii was isolated from human tissue. It is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium. Inquiry
Parabacteroides goldsteinii; 342457 LBST-045FG Parabacteroides Parabacteroides goldsteinii is a Gram-negative, obligately anaerobic non-spore-forming and non-motile bacterium from the genus of Parabacteroides. 200 µg $1,605.00
Parabacteroides goldsteinii Genomic DNA LBGF-0925-GF53 Parabacteroides DNA High-quality, intact genomic DNA isolated from Parabacteroides goldsteinii. Purified, ready-to-use for PCR, qPCR, and Next-Generation Sequencing. 5 µg $1,180.00

FAQs

Yes. Creative Biolabs can onboard your P. goldsteinii strain, confirm identity/traceability, and build a controlled cultivation plus assay plan around your target phenotype.

We control anaerobic handling, passage limits, and lot documentation, then verify consistency using pre-defined functional readouts relevant to P. goldsteinii MoA goals.

Yes. Project designs can include live P. goldsteinii and inactivated formats when appropriate, with safety-aligned characterization informed by published evaluation strategies.

Typically: viability/functional retention under temperature and humidity stress, packaging sensitivity, and timepoint comparability—so P. goldsteinii lots remain interpretable across studies.

References

  1. Lai, Hsin-Chih, et al. "Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide." Gut 71.2 (2022): 309-321. https://doi.org/10.1136/gutjnl-2020-322599
  2. Li, Zi, et al. "Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway." International Journal of Biological Macromolecules 277 (2024): 133726. https://doi.org/10.1016/j.ijbiomac.2024.133726
  3. Lin, Tzu-Lung, et al. "Amelioration of maternal immune activation-induced autism relevant behaviors by gut commensal Parabacteroides goldsteinii." International Journal of Molecular Sciences 23.21 (2022): 13070. https://doi.org/10.3390/ijms232113070
  4. Lai, Chih-Ho, et al. "Gut commensal Parabacteroides goldsteinii MTS01 alters gut microbiota composition and reduces cholesterol to mitigate Helicobacter pylori-induced pathogenesis." Frontiers in immunology 13 (2022): 916848. https://doi.org/10.3389/fimmu.2022.916848
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