Streptococcus spp. as Next Generation Probiotics

Live biotherapeutic products (LBPs) exert their effects through direct interactions with the complex native microbiota and/or the modulation of complex host-microbiota relation, indirectly leading to distant biological effects within the host. A new therapeutic approach based on LBPs has attracted increasing attention. With extensive expertise in the human probiotic field, Creative Biolabs contributes to the research and development of NGPs (next-generation probiotics). Today, we have discovered a lot of potential NGPs candidates.

Strategy for the development of engineered live bacterial therapeutic clinical candidates.Fig.1 Strategy for the development of engineered live bacterial therapeutic clinical candidates. (Charbonneau, 2020)

A complex interplay of metabolic and immunological mechanisms underlies many diseases that represent a substantial unmet medical need. There is an increasing appreciation of the role microbes play in human health and disease, and evidence is accumulating that a new class of live biotherapeutics comprised of engineered microbes could address specific mechanisms of diseases.

In the gut, probiotics can produce bactericidal proteins such as bacteriocins, antagonistic agents such as antibiotic-like compounds, and promote the production of metabolic end products that may help to prevent infections from various pathobionts microbes. Streptococcus thermophilus is an important regulator of uremic toxins in patients with chronic kidney disease. It may be able to prevent the progression of CKD (Chronic kidney disease) and remarkably reduce mucosal pro-inflammatory activity with the administration of probiotics that contain S. thermophilus.

Studies have shown that Streptococcus dentisani could inhibit the growth of caries-producing bacteria (such as Streptococcus mutans and Streptococcus sobrinus) and buffer extracellular acidic pH value, which is the underlying cause of dental caries. The reason is that strains 7746 and 7747T contain the key genes of the arginine deiminase system: arcA, arcC, and arcB. They participate in the ammonia generation through arginine metabolism, a mechanism to produce the alkalinization of the environment through the release of ammonia extracellularly.

The application of oral probiotics is becoming an attractive approach for prevention and therapy, especially for pediatric age patients. Streptococcus salivarius has properties suitable for bacterial treatment. It is a major colonist and non-pathogenic species of oral flora, which was widely used in the prevention of upper respiratory tract infections and in reducing the frequency of occurrence of its major pathogens.

Highlights of Our Streptococcus spp. Drug Discovery Services

  • Innovation: Our company cooperates with top international universities and is dedicated to the research of NGPs.
  • Quality stability: Our company has a wealth of experience in NGPs. For each test such as bacterial genetic features and physiological traits, growth dynamics, antibiotics sensitivity pattern tests, and screening and isolating the NGP, we will repeat the test more than 5 times to get stable and reliable data.
  • Instruments and reagents: Our instruments are highly accurate so we can distinguish subtle differences between different samples. Our reagents are from legal manufacturers and the quality of the reagents can be guaranteed.

Creative Biolabs strives to retain our customers through competitive cost, strong communication, timeliness, and responsive programs. We desire to work closely with clients to achieve long-term mutually beneficial relationships. If you want to experience our services and products, please feel free to contact us for more information.


  1. Charbonneau, M. R.; et al. Developing a new class of engineered live bacterial therapeutics to treat human diseases. Nature Communications. 2020, 11(1).

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