Streptococcus spp. as Next Generation Probiotics
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Background
Live biotherapeutic products (LBPs) exert their effects through direct interactions with the complex native microbiota and/or the modulation of complex host-microbiota relation, indirectly leading to distant biological effects within the host. A new therapeutic approach based on LBPs has attracted increasing attention. With extensive expertise in the human probiotic field, Creative Biolabs contributes to the research and development of NGPs (next-generation probiotics). Today, we have discovered a lot of potential NGPs candidates.
Fig.1 Strategy for the development of engineered live bacterial therapeutic clinical candidates.1
A complex interplay of metabolic and immunological mechanisms underlies many diseases that represent a substantial unmet medical need. There is an increasing appreciation of the role microbes play in human health and disease, and evidence is accumulating that a new class of live biotherapeutics comprised of engineered microbes could address specific mechanisms of diseases.
In the gut, probiotics can produce bactericidal proteins such as bacteriocins, antagonistic agents such as antibiotic-like compounds, and promote the production of metabolic end products that may help to prevent infections from various pathobionts microbes. Streptococcus thermophilus is an important regulator of uremic toxins in patients with chronic kidney disease. It may be able to prevent the progression of CKD (Chronic kidney disease) and remarkably reduce mucosal pro-inflammatory activity with the administration of probiotics that contain S. thermophilus.
Studies have shown that Streptococcus dentisani could inhibit the growth of caries-producing bacteria (such as Streptococcus mutans and Streptococcus sobrinus) and buffer extracellular acidic pH value, which is the underlying cause of dental caries. The reason is that strains 7746 and 7747T contain the key genes of the arginine deiminase system: arcA, arcC, and arcB. They participate in the ammonia generation through arginine metabolism, a mechanism to produce the alkalinization of the environment through the release of ammonia extracellularly.
The application of oral probiotics is becoming an attractive approach for prevention and therapy, especially for pediatric age patients. Streptococcus salivarius has properties suitable for bacterial treatment. It is a major colonist and non-pathogenic species of oral flora, which was widely used in the prevention of upper respiratory tract infections and in reducing the frequency of occurrence of its major pathogens.
Highlights of Our Streptococcus spp. Drug Discovery Services
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Innovation: Our company cooperates with top international universities and is dedicated to the research of NGPs.
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Quality stability: Our company has a wealth of experience in NGPs. For each test such as bacterial genetic features and physiological traits, growth dynamics, antibiotics sensitivity pattern tests, and screening and isolating the NGP, we will repeat the test more than 5 times to get stable and reliable data.
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Instruments and reagents: Our instruments are highly accurate so we can distinguish subtle differences between different samples. Our reagents are from legal manufacturers and the quality of the reagents can be guaranteed.
Creative Biolabs strives to retain our customers through competitive cost, strong communication, timeliness, and responsive programs. We desire to work closely with clients to achieve long-term mutually beneficial relationships. If you want to experience our services and products, please feel free to contact us for more information.
Related Products
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LBP-012FG
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Streptococcus thermophilus Powder
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Freeze-dried Streptococcus thermophilus Powder
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LBST-095FG
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Streptococcus thermophilus; PCI1327
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Streptococcus thermophilus is a Gram-positive bacterium, and a fermentative facultative anaerobe. It tests negative for cytochrome, oxidase, and catalase, and positive for alpha-hemolytic activity. It is non-motile and does not form endospores.
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LBST-096FG
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Streptococcus thermophilus; S01
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Streptococcus thermophilus was isolated from rhodian starter. It is a Gram-positive bacterium, and a fermentative facultative anaerobe. It tests negative for cytochrome, oxidase, and catalase, and positive for alpha-hemolytic activity. It is non-motile and does not form endospores.
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LBSX-0522-GF38
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Streptococcus salivarius subsp. salivarius
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Streptococcus salivarius is a species of spherical, gram-positive, facultative anaerobic bacteria that is both catalase and oxidase negative. It was isolated from healthy human oral.
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LBGF-0224-GF14
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Streptococcus agalactiae DNA Standard
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Streptococcus agalactiae DNA standard product can be used for quantitative research and analysis, assay development, verification, and validation, and laboratory quality control.
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LBGF-0224-GF30
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Streptococcus salivarius subsp. DNA Standard
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Streptococcus salivarius subsp DNA standard product can be used for quantitative research and analysis, assay development, verification, and validation, and laboratory quality control.
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LBGF-0224-GF47
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Heat inactivated Streptococcus salivarius
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Streptococcus salivarius has been inactivated by heating to 65°C for 30 minutes.
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Brochures
FAQs
What are the potential benefits of using Streptococcus spp. as next-generation probiotics in research?
Streptococcus spp. have shown promise in enhancing gut health, modulating the immune system, and inhibiting pathogen growth. Their diverse metabolic capabilities and adaptability make them suitable for developing new therapeutic strategies. These attributes can provide significant insights into their potential use in clinical settings.
How are Streptococcus spp. strains selected and characterized for probiotic applications?
The selection of Streptococcus spp. strains involves rigorous screening for safety, functional properties, and the ability to survive gastrointestinal conditions. Characterization includes genomic analysis, resistance to bile and acid, adherence to intestinal cells, and production of beneficial metabolites such as short-chain fatty acids and bacteriocins.
How can Streptococcus spp. probiotics be integrated into experimental designs for gut microbiota studies?
Streptococcus spp. probiotics can be administered to animal models or used in in vitro gut models to study their effects on microbiota composition, metabolic activity, and host interactions. Researchers can monitor changes in microbial diversity, immune responses, and overall health parameters to understand the probiotics' impact.
What are the key differences between Streptococcus spp. and traditional probiotics like Lactobacillus and Bifidobacterium?
Streptococcus spp. differ in their metabolic pathways, ability to produce specific enzymes and metabolites, and interactions with the host immune system. While Lactobacillus and Bifidobacterium are well-studied, Streptococcus spp. offer unique benefits, such as the production of antimicrobial peptides and enhanced colonization in specific gut niches.
What methods are used to evaluate the efficacy of Streptococcus spp. as next-generation probiotics?
Efficacy is evaluated through in vitro assays, animal studies, and clinical trials. Parameters include the ability to adhere to intestinal cells, resistance to gastrointestinal conditions, immunomodulatory effects, pathogen inhibition, and improvements in gut barrier function. Omics technologies, such as genomics and metabolomics, are also employed to understand their mechanisms of action.
Resources
Reference
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Charbonneau, Mark R., et al. "Developing a new class of engineered live bacterial therapeutics to treat human diseases." Nature Communications 11.1 (2020): 1738.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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