Live biotherapeutic products (LBPs) exert their effects through direct interactions with the complex native microbiota and/or the modulation of complex host-microbiota relation, indirectly leading to distant biological effects within the host. A new therapeutic approach based on LBPs has attracted increasing attention. With extensive expertise in the human probiotic field, Creative Biolabs contributes to the research and development of NGPs (next-generation probiotics). Today, we have discovered a lot of potential NGPs candidates.
Fig.1 Strategy for the development of engineered live bacterial therapeutic clinical candidates. (Charbonneau, 2020)
A complex interplay of metabolic and immunological mechanisms underlies many diseases that represent a substantial unmet medical need. There is an increasing appreciation of the role microbes play in human health and disease, and evidence is accumulating that a new class of live biotherapeutics comprised of engineered microbes could address specific mechanisms of diseases.
In the gut, probiotics can produce bactericidal proteins such as bacteriocins, antagonistic agents such as antibiotic-like compounds, and promote the production of metabolic end products that may help to prevent infections from various pathobionts microbes. Streptococcus thermophilus is an important regulator of uremic toxins in patients with chronic kidney disease. It may be able to prevent the progression of CKD (Chronic kidney disease) and remarkably reduce mucosal pro-inflammatory activity with the administration of probiotics that contain S. thermophilus.
Studies have shown that Streptococcus dentisani could inhibit the growth of caries-producing bacteria (such as Streptococcus mutans and Streptococcus sobrinus) and buffer extracellular acidic pH value, which is the underlying cause of dental caries. The reason is that strains 7746 and 7747T contain the key genes of the arginine deiminase system: arcA, arcC, and arcB. They participate in the ammonia generation through arginine metabolism, a mechanism to produce the alkalinization of the environment through the release of ammonia extracellularly.
The application of oral probiotics is becoming an attractive approach for prevention and therapy, especially for pediatric age patients. Streptococcus salivarius has properties suitable for bacterial treatment. It is a major colonist and non-pathogenic species of oral flora, which was widely used in the prevention of upper respiratory tract infections and in reducing the frequency of occurrence of its major pathogens.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.