Microbial Purification Service

A live biotherapeutic product (LBP) contains a live microorganism that is used for the prevention, treatment, or cure of a disease or condition. As the characterization of the human microbiome and its link to human health are being better understood, more and more microorganisms have been identified which may have a health benefit. Creative Biolabs provides industry-leading capabilities of LBPs’ purifying services to meet the growing research needs of our worldwide customers.

Microbial Purifying 

Biological purification technology is a necessary means to research bioactive substances. Biological purification technology is an essential link in food biotechnology. Biological purification technology is an important means of microbial product analysis or detection. The determination of absolute, as well as relative purity, presents considerable analytical challenges, and the results are highly method-dependent. Historically, the relative purity of a biological product has been expressed in terms of a specific activity (units of biological activity per mg of product) which is also highly method-dependent.

Table.1 Compounds of post-fermentative broth after 7 days of cultivation of the isolates. ¹

Highlights of Microbial Purifying Services

• Find the relevant data and establish the basic purification method.
• The preliminary experiment of microbial product purification was carried out.
• Separate and purify all kinds of microbial products, and formulate reasonable purification procedures and perform effect evaluation for your products.
• Purity test of live microbial products (determination of endotoxin content, residual antibiotics, and/or quantification of residual toxic components or contaminants introduced in the manufacturing process).
• The homogeneity of the purified product was determined.
• Determination of the potency of live microbial products.
• Additional tests or modifications such as percentage of live cells, particulate matter determination, pH test and/or residual moisture test.
• Development of fermentation and downstream processes.
• Prediction and analysis of strain activity.

Why Choose Creative Biolabs' Microbial Purifying Services?

• Creative Biolabs is committed to providing overall solutions for probiotic drug discovery, focusing on innovative research and development of probiotics industrialization.
• Our staff has the operational grit and scientific background that you need for your success. We have 90% retention of our employees, a management team with an average of 10+ years of LBP industry experience.
• We deliver high-quality data by applying specific criteria during the process to ensure robustness and reproducibility.
• Direct interactions with a dedicated project team at each project step, providing insights and proposing strategies.

Creative Biolabs’ team has accumulated abundant experience to provide an integrated and high-quality LBP discovery service. We have won a good reputation among our worldwide customers for accomplishing numerous challenging projects in microbial purifying services. Please contact us for more scientific support.

References

1. Szymanowska-Powałowska, Daria, Joanna Piątkowska, and Katarzyna Leja. "Microbial purification of postfermentation medium after 1, 3‐PD production from raw glycerol." BioMed Research International 2013.1 (2013): 949107.
2. Distributed Under Open Access license CC BY 3.0, without modification.