Live Biotherapeutics Drug Discovery Services for Urinary Tract Disorders

Urinary tract infection (UTI) still represents a significant bother for women and result in high costs to the health system. Increasing antimicrobial resistance has stimulated interest in probiotic prophylaxis of recurrent UTIs. With our state-of-the-art technology and substantial experience, Creative Biolabs has developed a cutting-edge platform for next-generation probiotics (NGPs) identification and characterization. Our scientists are pleased to share our knowledge of NGPs to facilitate our customers' project development in the research of UTI.

Introduction of UTI

UTI is the most frequent bacterial infection in polyclinic and service patients. This disease has afflicted a great number of women around the world. The incidence of UTI is most common between the ages of 18-24. The most prominent feature of UTI in women is its tendency to recur. Treatment of UTI with antibiotics causes antibiotic resistance among uropathogenic microorganisms and other bacteria in the body. Increasing antimicrobial resistance has stimulated interest in non-antibiotic prophylaxis of recurrent UTIs, as a result of resistance developing against antibiotherapy and also the tendency of the patients towards antibiotic-free treatment alternatives. Studies have shown that probiotics could be a good alternative to antibiotic therapy because of their ability to bind to uroepithelial cells and inhibit pathogenic growth, and biosurfactant secretion.

UTI and Probiotics

It is well-known that there is an association between abnormal vaginal microbial flora and an increased incidence of UTI. Balancing the number of Lactobacillus spp. via the supplementation of probiotics would be the primary solution for the compromised state. Many in vitro studies, animal experiments, microbiological studies in healthy women, and clinical trials in women with UTIs have been carried out to assess the effectiveness and safety of probiotics for prophylaxis against uropathogens. Most of them had encouraging findings for some specific Lactobacillus strains. Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 seemed to be the most effective among the studied lactobacilli for the prevention of UTIs. Lactobacillus casei shirota and Lactobacillus crispatus CTV-05 have also shown efficacy in some studies.

NGPs Discovery Service at Creative Biolabs

The increased awareness about the harmful effects of excessive use of antibiotics has created an interest in probiotics due to its beneficial effects on gut microbiota. These advantages of probiotics have attracted researchers to find out effects on human metabolism and their role in the treatment of UTI.

With top-class scientific experts and state-of-the-art technologies in live biotherapeutics drug discovery, Creative Biolabs is committed to providing overall solutions for the development of NGPs. We are fully competent and dedicated to serving as your one-stop-shop for the identification, characterization, and scale-up GMP manufacturing of NGPs. For more detailed information, please feel free to contact us or directly send us an inquiry.


  1. Falagas, M.E.; et al. Probiotics for prevention of recurrent urinary tract infections in women. Drugs. 2006, 66(9): 1253-61.

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