Microbial Fermentation Services
Background Services Capabilities Advantages Resources
As a leader in LBPs solutions and microbial fermentation, Creative Biolabs provides the most advanced facilities, capabilities, and expertise to accelerate the development and clinical application of LBPs. With our state-of-the-art technology and industry-leading expertise, Creative Biolabs has an unparalleled track record in working with many different types of LBPs and providing highly complex fermentation services, from strain development to large-scale manufacturing.
Background
Live biotherapeutic products (LBPs) are defined as live organisms (bacteria or yeast) designed and developed to treat, cure, or prevent multiple human indications. Due to the unique characteristics of live organisms, the development of robust fermentation and downstream processes to balance biomass production and engineered circuit expression is comparatively important. Developing robust fermentation and downstream processes is essential for the generation of individual commercial probiotic strains at scale and relatively low cost. Recently, automated parallel bioreactor systems allowing for accurate measurement and control of pH, dissolved oxygen, and temperature, as well as the automated addition of nutrients and chemical inducers during growth have been developed for microbial fermentation.
Microbial Fermentation Services
Supported Microbial Types
-
Aerobes
-
Anaerobes
-
Spore formers
Service Items
-
Acquisition and fermentation of microbial strains.
-
Domesticate strains and optimize fermentation parameters.
-
Improve microbial fermentation yield.
-
For other requirements, please contact us for detailed communication.
The production level of microbial fermentation not only depends on the performance of the producing strain but also requires the best environmental conditions to fully exploit its production capacity, such as the fermentation process and the fermentation medium. Different LBPS contain different microbes, Creative Biolabs can explore the best fermentation conditions for different strains, and develop the most appropriate optimization proposal for your products to maximize the yield level. Please click the title for more details on optimizing the service.
Scale Fermenters (For laboratory or preclinical studies)
-
Flasks
-
5L
-
60L
-
For a larger scale, please contact us to confirm.
Sample Submission
If you are ready to submit your samples for testing or development, please fill out the Sample Submission Form.
Deliverables
-
Upon completion of the development services, a final report will be issued.
-
Deliver the products obtained during the development process (if required).
Capabilities
-
Different live organisms (aerobic and anaerobic bacteria, yeast)
-
Fully instrumented fermentation suite to avoid batch-to-batch differences
-
Small-scale development projects
-
Subsequent downstream processing, validation, purification, and lyophilization
-
In-process and end-product analytics with robust testing methods
-
Multiple media options to ensure high yield
-
Relatively cost-effective and easy to scale up
-
Close collaboration to facilitate seamless transitions between project phases
Why Us?
-
Flexibility - tailored strategies to meet different demands for pre-clinical studies
-
Scalability - the strategy addresses small-scale development projects and scaled-up fermentation
-
Universality - the strategy is easily adapted for the fermentation of diverse microbe strains
-
Optimization - continuous optimization development to choose the best pH, dissolved oxygen, temperature, etc.
-
Low cost - competitive price with high-quality services
Related Resources
Microbial fermentation is the basis for the production of LBPs to promote effective live biotherapeutics. Creative Biolabs offers full fermentation services spanning many organisms, stages, industries, and production volumes. Our fermentation is commonly done at scale and relatively low cost. If you are interested in our services, please feel free to contact us.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
Related Services
