Livestock Health & Probiotic Solution

Q: How do you determine whether probiotics are beneficial to animals? What is your process?

We arranged some experiments where some animals were given probiotics while others were not, and then closely monitored their growth conditions and even their utilization of feed.

Q: In these probiotic studies, what tests did you conduct on animals? Just looking at them?

Not just watching! We will collect data, such as body weight, feed intake. Sometimes we collect samples like blood or intestinal swabs.

Promoting the health and productivity of livestock depends on evidence-based intervention measures, and probiotics are a promising solution. Creative Biolabs has accumulated rich project experience in the field of probiotics, established an advanced technology platform, and provides comprehensive cutting-edge probiotic solutions. Request a quote

Overview of Probiotics in Modern Livestock Management

Contemporary animal agriculture presents complex stress factors, including pathogenic challenges, nutritional transitions and environmental changes, etc. Probiotics offer an ecologically reasonable strategy to alleviate these pressures in the following ways:

Restoring and Maintaining Gut Microbiota Balance.
Enhancing Nutrient Digestion and Absorption.
Strengthening the Host Immune System.
Improving Growth Performance and Productivity.
Reducing the Need for Antibiotics.
Potentially Mitigating Environmental Impact.

Fig.1 The application of Probiotics in cattle. (Creative Biolabs Authorized)

Comprehensive Probiotic Research Services for Livestock Health

In Vitro Services

In Vivo Services

In Vitro Services

Probiotic Strain Isolation and Identification
- Isolation of potential probiotic candidates from diverse sources.
- Phenotypic characterization: Evaluate growth kinetics, tolerance to simulated gastrointestinal conditions, adhesion and safety.
- Genotypic characterization: sequencing for species identification.
In Vitro Efficacy Screening
- Assessment of antimicrobial activity against relevant livestock pathogens.
- Evaluation of immunomodulatory potential in cell culture models.
- Assessment of enzymatic activity relevant to digestion.
- Evaluation of prebiotic utilization and production of beneficial metabolites.
- Biofilm inhibition assays against pathogenic bacteria.
Formulation Development and Optimization (Preclinical Stage)
- Design and testing of various probiotic formulations.
- Evaluation of probiotic viability and stability under different storage conditions.
- Compatibility testing with feed ingredients and delivery systems.
- Development of synbiotic formulations with prebiotics.

In Vivo Services

Pilot Efficacy Studies in Animal Models
- Assess the preliminary efficacy of probiotic candidates in improving growth performance, feed efficiency, immune parameters, and resistance to specific challenges.
- Collection of biological samples for downstream analysis.
- Measurement of key outcome parameters relevant to the study objectives.
Safety and Toxicology Studies in Animal Models
- Acute and sub-acute toxicity studies in relevant animal models to evaluate the safety profile of probiotic candidates at different dosages.
- Assessment of potential adverse effects on animal health, behavior, and physiology.
- Evaluation of potential for horizontal gene transfer of antibiotic resistance genes from the probiotic to the host microbiota.
Pharmacokinetic and Pharmacodynamic Studies
- Assessment of probiotic survival, colonization, and distribution within the gastrointestinal tract of animal models using culture-dependent and culture-independent methods.
- Gut Microbiota Analysis using Animal Models
- Collection and processing of fecal and gut content samples from animal models.
- Advanced metagenomic sequencing (16S rRNA gene sequencing, whole-metagenome sequencing) to characterize the composition and diversity of the gut microbial community.
- Comprehensive bioinformatic analysis and interpretation of microbiome data.
Customized Animal Models for Specific Research Questions
- Development and utilization of specific animal models to address targeted research questions related to probiotic efficacy in specific contexts.

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Our Range of Probiotic Products for Preclinical Research

Single Strain Cultures (Research Grade): We have a comprehensive probiotic product library, including Lactobacillus, Bacillus, Bifidobacterium, yeast, Enterococcus and Pediococcus, etc.
Custom Mixed Cultures (Research Grade): Study the beneficial effects of microbial communities.
Research-Grade Synbiotics: Probiotics are combined with multiple prebiotics to evaluate the synergistic effects of probiotics and prebiotics on the gut microbiota and host health.
Encapsulated Probiotic Formulations (for research): Different techniques are used to encapsulate single or multiple strains of probiotics to study the effects of encapsulation on the survival, targeted delivery and efficacy of probiotics in animal models, etc.
Custom Probiotic Preparations (for research): We can customize probiotic culture and formulas based on your research needs, including specific strains, concentrations and delivery forms.
Case List of Probiotics Used in Livestock Research

Probiotic Species/Genus	Specific Strains	Focus Areas	Application Forms
Lactobacillus	L. acidophilus L. casei L. plantarum L. rhamnosus	Gut health Immunity growth promotion, pathogen inhibition	Pure cultures lyophilized powders Encapsulated forms
Bacillus	B. subtilis B. licheniformis B. amyloliquefaciens	Growth promotion Immune modulation disease resistance	Spore suspensions Lyophilized powders Feed admixtures for models
Bifidobacterium	B. animalis B. breve B. longum	Early life gut development Immune priming	Pure cultures Lophilized powders Formulations for neonates
Saccharomyces cerevisiae	Various strains	Rumen function Growth performance Immune support	Yeast cultures Died yeast preparations
Enterococcus faecium	Specific strains	Gut health Growth promotion	Pure cultures Lyophilized powders
Pediococcus acidilactici	Specific strains	Gut health Pathogen inhibition	Pure cultures Lyophilized powders

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Mechanisms of Action: How Probiotics Work Their Magic

Competitive exclusion
Production of antimicrobial substances
Enhancement of gut barrier function
Modulation of the immune system
Production of beneficial metabolites
Enzymatic activity
Quorum sensing interference

Advantages

Deep Scientific Expertise
State-of-the-Art Preclinical Research Facilities
Comprehensive and Integrated Services
High-Quality Research Products
Customized Research Solutions
Rigorous Scientific Standards
Comprehensive Data Analysis and Interpretation
Accelerated Preclinical Development Timelines

Who We Serve: Our Target Customer Groups

Fig.2. Preparation of Probiotics. (Creative Biolabs Authorized)

Animal Health and Nutrition Companies
Feed Manufacturers and Suppliers
Agricultural Biotechnology Firms
Veterinary Pharmaceutical Companies
Research Institutions and Universities
Government and Regulatory Agencies
Livestock Producers

Creative Biolabs' commitment is to provide you with probiotic resources (including services and products), maximizing their potential to improve livestock health and productivity. Cooperating with us can accelerate your research and development work. We invite you to contact us for a tailor-made discussion to explore how our expertise in livestock probiotics innovation can make a valuable partnership.

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FAQs

How do you determine whether probiotics are beneficial to animals? What is your process?

In these probiotic studies, what tests did you conduct on animals? Just looking at them?

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

Accelerate Livestock Health: Probiotic Solution & CRO Service