Pioneering the Future of Antifungal Solutions: Your Partner in Discovery & Development

Fungal infections represent a significant and growing threat across various sectors, from devastating diseases in Human Health and Animal Health to widespread crop losses in Agriculture. The emergence of antifungal resistance, coupled with a limited arsenal of effective treatments, underscores an urgent global need for innovative antifungal solutions. At Creative Biolabs, we stand at the forefront of this critical research, offering unparalleled expertise and cutting-edge Contract Research Organization (CRO) services to accelerate the discovery, development, and delivery of novel antifungal agents. Request a quote

Explore Our Specialized Antifungal Research Areas

Human Health

Animal Health

Agriculture

Basic Research & Diagnostic

At Creative Biolabs, we are dedicated to advancing antifungal science through our state-of-the-art facilities, experienced scientific team, and comprehensive suite of CRO services. We offer end-to-end support for your antifungal drug discovery and development programs, from early-stage discovery to preclinical research.

Comprehensive Antifungal CRO Services

• Target Identification and Validation: Utilizing cutting-edge bioinformatics, genomics, and proteomics, we identify and validate novel fungal drug targets.
• High-Throughput Screening (HTS): Our advanced HTS platform is capable of rapidly screening large compound libraries against various fungal pathogens.
• Lead Identification and Optimization
  
  • Antifungal Susceptibility Testing (AST): Utilizing standardized methodologies (e.g., CLSI guidelines), we determine MIC and MFC values.
  • Mechanism of Action (MOA) Studies: Employing a variety of cellular, molecular, and biochemical techniques (e.g., macromolecular synthesis inhibition, enzyme assays, cell lysis assays), we elucidate how your compounds exert their antifungal effects.
  • In Vitro Pharmacodynamics (PD) Studies: We assess an agent's ability to kill or suppress fungal growth through time-kill assays, MFC, and post-antifungal effect studies.
  • Resistance Development Studies: We evaluate the potential for fungi to develop resistance to novel agents using spontaneous mutation frequency (SMF) assays and serial passage experiments.
  • Drug Combination Studies: We investigate synergistic, additive, or antagonistic effects of combination therapies.
• Preclinical In Vitro and In Vivo Efficacy Studies: We design and execute robust preclinical models to assess the efficacy of your antifungal candidates.
• ADME/PK Profiling: We provide comprehensive data on absorption, distribution, metabolism, and excretion, as well as pharmacokinetic parameters to inform drug development.
• Toxicology and Safety Assessment: We conduct thorough toxicology studies to ensure the safety profile of your compounds.
• Formulation Development: Our experts assist in developing optimal formulations for your antifungal agents.

Get a Quote Now →

Unraveling Fungal Vulnerabilities: Mechanisms of Antifungal Action

• Cell Membrane Disruption

Polyenes bind to ergosterol, a fungal-specific sterol, leading to pore formation and membrane permeability. Azoles and allylamines inhibit ergosterol biosynthesis, disrupting membrane integrity.

• Cell Wall Inhibition

Acanthomycin targets the synthesis of β-1, 3-D glucan, which is an important structural component of the fungal cell wall, leading to osmotic instability and cell lysis.

• Nucleic Acid Synthesis Inhibition

Flucytosine (5-FC) is an antimetabolite that interferes with fungal DNA and RNA synthesis.

Our Research Advantages & Company Strengths: Your Partner in Innovation

• Deep Mycology Expertise: Our team comprises highly experienced mycologists, microbiologists, pharmacologists, and toxicologists with a profound understanding of fungal biology and infectious diseases.
• State-of-the-Art Facilities: We operate BSL-compliant laboratories, and utilize advanced analytical platforms to ensure high-quality, reproducible data.
• Customized Solutions: We work closely with our clients to design tailor-made study plans based on their specific research goals and schedules.
• Integrated Approach: Our seamless integration of discovery biology, pharmacology, and toxicology services provides a holistic view of compound performance.

Target Customer Groups

• Pharmaceutical and Biotechnology Companies: Seeking to accelerate their antifungal drug discovery and development pipelines.
• Academic Institutions and Research Organizations: Requiring specialized preclinical services for their basic and translational mycology research.
• Government and Non-Profit Organizations: Focused on developing new solutions for public health threats posed by fungal infections.
• Veterinary Pharmaceutical Companies: Developing antifungal solutions for animal health.
• Agrochemical Companies: Focused on developing new fungicides for crop protection.
• Diagnostic Companies: Developing and validating innovative fungal diagnostic tools.

Beyond the Horizon: Your Partner in Antifungal Innovation

The battle against fungal infections is a dynamic and challenging effort. At Creative Biolabs, we are committed to being your dedicated partner in this critical mission. Ready to advance your antifungal research? Explore our specialized services and discover how Creative Biolabs can be your trusted partner in developing the next generation of life-saving antifungal solutions. Contact us immediately to discuss your antifungal research needs and learn how we can accelerate your success.

FAQs