Invasive fungal infections represent a growing threat to public health, particularly among immunocompromised patient populations. The need for effective and novel antifungal therapies is more critical than ever, and preclinical research is the cornerstone of successful drug development. Our Systemic Fungal Infection Modeling & Evaluation service provides a robust and reliable platform to test your candidate compounds, from initial screening to in-depth efficacy and mechanism-of-action studies. Contact Us for a Customized Quote
Overview
We are a leading Contract Research Organization (CRO) specializing in the preclinical evaluation of anti-infective agents. Our service is designed to support pharmaceutical, biotechnology, and academic researchers at every stage of their antifungal development pipeline. We offer a holistic approach, integrating advanced in vitro and in vivo models to provide a complete picture of your compound's efficacy, safety, and pharmacodynamics.
Our core competency lies in creating and evaluating clinically relevant animal models that closely mimic human systemic fungal infections, allowing for high-predictability data that informs critical go/no-go decisions.
Detailed Scope of Services
Our service offerings are flexible and can be customized to your specific research goals. We offer a full range of services to support your entire pre-clinical program.
Workflow
Service Details
Deliverables
Turnaround Time
In Vitro Services
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Antifungal Susceptibility Testing
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Broth microdilution (CLSI and EUCAST standards).
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Disk diffusion and Etest.
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Determination of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC)
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Time-Kill Kinetics: Assessing the rate of fungal killing over time.
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High-Throughput Screening (HTS): Rapid screening of large compound libraries for primary hits.
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Mechanism of Action Studies: Cell-based assays to determine the specific target and pathway affected.
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Combination Studies: Evaluating the synergistic effects of your compound with existing antifungals.
In Vivo Services (Animal Models)
We utilize a variety of species, with a focus on rodent models (mice, rats) due to their well-established protocols and relevance to human disease. Our validated models include:
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Systemic Candidiasis (e.g., Candida albicans, C. auris)
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Intravenous (IV) Infection Model: The "gold standard" for mimicking disseminated candidiasis. Fungal cells are injected into the tail vein, leading to systemic infection, primarily affecting the kidneys. We can model both immunocompetent and immunosuppressed hosts.
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Gastrointestinal Colonization and Dissemination Model: Mimics the development of infection from the gut, a common clinical scenario.
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Invasive Pulmonary Aspergillosis (e.g., Aspergillus fumigatus)
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Intranasal or Intratracheal Infection Model: Simulating the inhalation of fungal spores, leading to lung infection. We can induce immunosuppression to mirror the at-risk patient population.
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Cryptococcosis (e.g., Cryptococcus neoformans)
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Intravenous or Intranasal Model: For evaluating drugs against disseminated cryptococcal disease, particularly in the central nervous system.
Deliverables
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A detailed final report.
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Raw data files in an accessible format.
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High-resolution images of histopathology slides.
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Statistical analysis and graphical representation of all key endpoints.
Turnaround Time
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In Vitro Assays: Typically 4-6 weeks, depending on complexity.
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In Vivo Studies: Typically 8-12 weeks, depending on the model, study duration, and endpoints. A detailed timeline will be provided in the study proposal.
Ready to discuss your project? Let us get in touch and explore how our consulting services can help you achieve your goals.
Mechanism of Action & Translational Relevance
Our modeling services are built on the principle of replicating the complex interplay between the fungal pathogen, the host's immune system, and the therapeutic agent. We go beyond simple survival studies to provide a detailed, mechanistic understanding of your compound's efficacy.
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Antifungal Efficacy: Evaluating the ability of your compound to reduce fungal burden in various organs and tissues.
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Host Immune Response: Analyzing the modulation of the host's immune system by your compound and its impact on infection outcome.
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Pharmacokinetics/Pharmacodynamics (PK/PD): Correlating drug exposure with biological response to determine the optimal dosing regimen.
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Fungal Pathogenesis: Studying the effects of your compound on fungal virulence factors, such as biofilm formation, spore germination, and host tissue invasion.
The models we utilize are carefully selected and validated to mimic human disease, ensuring that the data we generate is highly predictive of clinical outcomes.
Our Advantages
Deep Expertise
Our team of mycologists and infectious disease specialists has extensive experience in preclinical antifungal studies.
Validated Models
We utilize established, clinically relevant models to ensure high-quality and predictive data.
Customization
We tailor our services to meet your specific research needs and budget.
State-of-the-Art Facilities
Our facilities are equipped with advanced technology for high-throughput screening and in-depth analysis.
Quality and Compliance
We adhere to rigorous quality control procedures and GLP-like standards to ensure data integrity and reliability.
Applications
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Pharmaceutical Companies: For preclinical development and IND-enabling studies.
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Biotechnology Companies: For lead identification, optimization, and validation.
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Academic Researchers: For studying fungal pathogenesis and testing novel compounds.
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Government and Non-Profit Organizations: For research on new therapies for neglected tropical diseases and emerging fungal pathogens.
Your next breakthrough is just a conversation away. Let's talk about your challenges and find a custom solution together.
FAQs
Do you offer GLP-compliant studies?
We conduct studies under GLP-like conditions, adhering to strict quality standards. Please discuss specific GLP requirements with our team during the consultation.
What is the cost of your services?
Costs are project-specific and depend on the scope, duration, and complexity of the study. We provide a detailed, no-obligation quotation after an initial consultation.
How do I get started?
Simply fill out our inquiry form or contact our team directly. We will schedule a consultation to discuss your project and provide a customized proposal.
