Lab-scale Production Services
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Background
Live biotherapeutics are a class of medicines which is used for the prevention, treatment, or cure of a disease or condition. In the early development stages of live biotherapeutics, lab-scale production provides a more flexible platform for the research and application of live biotherapeutics. Creative Biolabs is equipped with state-of-the-art production facilities and rich experience to support high-quality custom-made production of live biotherapeutics at a lab-scale level.
Creative Biolabs' Lab-scale Production Services
Creative Biolabs is committed to providing comprehensive lab-scale production services for live biotherapeutics and probiotics lab research, and preclinical trials. Our capacities include but are not limited to the following:
The freeze-drying technology has been used in the preservation of bacterial strains for several applications, mainly in the production of probiotics for the treatment of gastrointestinal disorders. Creative Biolabs offers freeze-drying services for clients who wish to preserve their bacterial or fungal cultures and maintain their properties or for animal studies.
Cell membrane-derived bacterial extracellular vesicles (BEVs) can transport various bioactive molecules to recipient cells, thereby changing the physiology of those cells. BEVs have been widely investigated as biotherapeutics due to their drug-loading capacity, immunostimulatory capability, and ease of modification.
The microbiota of the human gut has numerous beneficial functions, such as immune system development, resistance to pathogens, vitamin synthesis, production of metabolites such as short-chain fatty acids (SCFAs), nutrient and drug metabolism, and maintenance of the structural integrity of the intestinal mucosal barrier.
Supernatants produced from cultures of different microorganisms show differing activities. Cell-free bacterial supernatants are promising anti-infectious agents, for example, for the treatment of diarrhea.
Advantages of Lab-scale Production of Live Biotherapeutics
Live biotherapeutics are a class of medicines which is used for the prevention, treatment, or cure of a disease or condition. In the early development stages of live biotherapeutics, lab-scale production provides a more flexible platform for the research and application of live biotherapeutics. Compared with large-scale production, lab-scale production has several advantages:
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Low Cost: Lab-scale production refers to the production of a live biotherapeutic product with a lab for research use. It requires less capital, time, and manpower.
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Low Risk: Lab-scale production can adjust its production strategy in time to avoid material waste.
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Customizable production.: Lab-scale production pays more attention to customers' needs and can adjust production strategies according to customers' temporary decisions.
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Suitable for early development and academic research projects of live biotherapeutics.
Production Capacities
Creative Biolabs has rich experience in producing custom non-GMP live biotherapeutic products. We are equipped with a full range of powerful production facilities, including:
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Anaerobe chambers with internal HEPA filtration for aseptic, anaerobic fill capability.
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Filling equipment.
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Freeze drying equipment.
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Homogenizer mixer.
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Other conventional instruments and equipment are required for microbial technology platforms.
Brochures
Frequently Asked Questions
How does Creative Biolabs produce lab-scale probiotic-related products?
Communicate with the client to confirm the required strains for the project, then select the most suitable culture medium and culture conditions for preliminary experiments to gain a preliminary understanding of the strain's CFU. Subsequently, formal fermentation, freeze-drying, and counting of the final product's CFU are carried out to ensure compliance with specifications.
Does Creative Biolabs have service cases?
What are next-generation probiotics?
Next Generation Probiotics (NGPs) is an innovative group of beneficial bacteria that are not only designed for routine use in foods or dietary supplements but can also be developed to treat or improve a variety of diseases, and many probiotics are currently under research and development.
Equipped with world-class production facilities and comprehensive expertise, Creative Biolabs specializes in providing a wide range of services for the production of live biotherapeutics. Please contact us to help you develop and produce products for your live biotherapeutics research.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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