Lab-scale Production Services

Compared with large-scale production, lab-scale production has several advantages, such as flexibility, low cost, low risk, personal attention to customers, etc. Creative Biolabs is equipped with state-of-the-art production facilities and rich experience to support high-quality custom-made production of live biotherapeutics at a lab-scale level.

Advantages of Lab-scale Production of Live Biotherapeutics

Live biotherapeutics are a class of medicines which is used for the prevention, treatment, or cure of a disease or condition. In the early development stages of live biotherapeutics, lab-scale production provides a more flexible platform for the research and application of live biotherapeutics. Compared with large-scale production, lab-scale production has several advantages:

  • Low Cost: Lab-scale production for live biotherapeutics refers to the production of a live biotherapeutic product with a small plant-size firm. It requires less capital, time, and manpower.
  • Low Risk: Lab-scale production can adjust its production strategy in time to avoid material waste.
  • Personal Attention to Customers: Lab-scale production pays more attention to customers' needs and can adjust production strategies according to customers' temporary decisions.
  • Suitable for early development and production of live biotherapeutics.

Production Capacities

Creative Biolabs has rich experience in producing custom non-GMP live biotherapeutic products. We are equipped with a full range of powerful production facilities, including:

  • Biological safety cabinets.
  • Anaerobe chambers with internal HEPA filtration for aseptic, anaerobic fill capability.
  • Incubators and warm room.
  • Tangential flow filtration equipment.
  • Filling equipment.
  • Freeze drying equipment.
  • Homogenizer mixer.
  • Spectrophotometers.

Schematic representation of probiotic bacterium production.Fig.1 Schematic representation of probiotic bacterium production. (Arthur, 2018)

Our Lab-scale Production Services

Creative Biolabs is committed to providing comprehensive lab-scale production services for live biotherapeutics and probiotics lab research, and preclinical trials. Our capacities including but not limited to the following:

The freeze-drying technology has been used in the preservation of bacterial strains for several applications, mainly in the production of probiotics for the treatment of gastrointestinal disorders. Creative Biolabs offers freeze-drying services for clients who wish to preserve their bacterial or fungal cultures and maintain their properties.

Cell membrane-derived bacterial extracellular vesicles (BEVs) can transport various bioactive molecules to recipient cells, thereby changing the physiology of those cells. BEVs have been widely investigated as biotherapeutics due to their drug-loading capacity, immunostimulatory capability, and ease of modification.

The microbiota of the human gut has numerous beneficial functions, such as immune system development, resistance to pathogens, vitamin synthesis, production of metabolites such as short-chain fatty acids (SCFAs), nutrient and drug metabolism, and maintenance of the structural integrity of the intestinal mucosal barrier.

Supernatants produced from cultures of different microorganisms show differing activities. Cell-free bacterial supernatants are promising anti-infectious agents, for example, for the treatment of diarrhea.

Highlights of Lab-scale Production Services

  • A competent and professional team.
  • Customizable production.
  • High-quality product delivery.
  • Shorter production cycle.

Equipped with world-class production facilities and comprehensive expertise, Creative Biolabs is specialized in providing a widely full range of services for the production of live biotherapeutics. Please contact us to help you develop and produce products for your live biotherapeutics research.


  1. Arthur, C.O.; et al. Chapter 16-Production of probiotic bifidobacteria. Bifidobacteria & Related Organisms. 2018: 261-269.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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