Eggerthellaceae Family as Next Generation Probiotics

Species of Eggerthellaceae family have been revealed to convert in vitro ellagic acid (EA) into the final metabolite isolecithine-A (a urolithin) which is responsible for the health effects of ellagitannin and EA. Hence, urolithin-producing Eggerthellaceae members are considered as potential probiotics to improve the effects of ellagitannins and EA on health. Creative Biolabs is a world-leading service provider who is fully committed to offering the best next-generation probiotics development services for customers around the world based on a variety of technologies.

Introduction of Eggerthellaceae Family

Eggerthellaceae Family

Eggerthellaceae family belongs to the phylum Actinobacteria, originally proposed and validated by Gupta et al. 2013. The family contains nine different genera, Adlercreutzia, Asaccharobacter, Cryptobacterium, Denitrobacterium, Enterohabdus, Gordonibacter, Paraeggerthella, and Slackia. Species of this family are strictly anaerobic. They are asaccharolytic rods or cocci and do not form spores. All members except Gordonibacter do not form flagella. The G+C content of the family members ranges from 50 to 67 mol %. Species of the family are typical members of the mammalian gut and have been isolated from humans, mice, and sheep.

Potential of Eggerthellaceae Family as Next-generation Probiotics

Polyphenols ellagitannins and EA are two bioactive molecules that are responsible for health effects. People intake them by eating some fruits such as walnuts, strawberries, and pomegranates. However, ellagitannin consumption varies from person to person, mainly due to the composition of their gut microbiota. Members of the family Eggerthellaceae have been reported to be able to convert in vitro EA into the final metabolite isolecithine-A (a urolithin) which exerts anti-inflammatory, anti-carcinogenic, cardioprotective, and neuroprotective properties. This metabolite is much better absorbed than EA and is thought to contribute to the health effects of ellagitannin and EA. Hence, isolecithine-A-producing Eggerthellaceae members are considered as potential novel probiotics with applications in the development of functional foods and nutraceuticals. Their administration could improve the health effects attributed to the consumption of ellagitannins and EA, especially in metabotype 0 individuals who are not able to produce bioactive urolithins. However, it is necessary to further explore well-established beneficial effects of Eggerthellaceae species on the host and safety requirements before being considered among the next-generation probiotics.

Catabolic pathway for EA by intestinal bacteria. Fig.1 Catabolic pathway for EA by intestinal bacteria. (Selma, 2017)

What Can We Do?

Creative Biolabs is an outstanding expert in the development of next-generation probiotics. Equipped with a powerful technology platform and professional staff, we are committing to offering the best and affordable services to advance the development of next-generation probiotics. Our service package includes identification and isolation of next-generation probiotics, safety test for probiotics products, host-microbe interaction test, and cGMP manufacturing of probiotics products. Besides, we also offer personalized services according to your special requirements.

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References

  1. Gupta, R.S.; et al. Molecular signatures for the class Coriobacteriia and its different clades; proposal for division of the class Coriobacteriia into the emended order Coriobacteriales, containing the emended family Coriobacteriaceae and Atopobiaceae fam. nov. and Eggerthellales ord. nov. containing the family Eggerthellaceae fam. nov.. International Journal of Systematic & Evolutionary Microbiology. 2013, 63(Pt 9):3379-3397.
  2. Selma, M.V.; et al. Isolation of human intestinal bacteria capable of producing the bioactive metabolite isourolithin A from ellagic acid. Frontiers in Microbiology. 2017, 8:1521.

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