Zebrafish Model related Services for Live Biotherapeutics Drug Discovery
Background Services Advantages FAQs
Background
Zebrafish have become a widely used vertebrate model in the field of biological research, and their high degree of physiological and genetic homology with humans makes Zebrafish a powerful model organism for studying neurological diseases and identifying potential therapeutic targets, and an attractive animal model for understanding the pathogenesis of human metabolic diseases and identifying potential therapeutic options. Zebrafish models are a valuable scientific tool that can be used to test a range of bioactive chemicals, including those that induce or disrupt development, improve disease conditions, or cause adverse side effects in everyday human health or anti-cancer treatments. An extensive toolbox has been developed to study this organism, positioning the zebrafish as a valuable in vivo research tool capable of generating high-throughput data in drug discovery.
Our Preclinical Research Service Based on Zebrafish Models
Accelerate Drug Discovery
The zebrafish provides a unique platform for studying drug delivery mechanisms and evaluating the effectiveness and safety of new treatments because of its genetic and brain structure homology with humans. They can be used in the early stages of drug development using two main approaches: target-based approaches and phenotype-based approaches. Currently, zebrafish are widely used as in vivo phenotypic screening platforms and have led to the development of several successful therapies. With the development of gene-editing tools and next-generation sequencing technologies, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. A drug discovery platform based on zebrafish organelle biology could play an important role in the development of precision medicine and the next generation of disease treatments. They serve as an excellent model system for evaluating in vivo toxic reactions to the treatment of chemicals of interest.
Fig.1 The use of zebrafish as a predictive preclinical model to accelerate various stages of drug development, from early discovery to preclinical development.1, 2
Drug Administration in Zebrafish Models
In terms of drug delivery, transparent zebrafish, especially in the larval stage, provide a great platform for delayed evaluation of the drug delivery system's efficacy, therapeutic effectiveness, off-target effects, and potential toxicity risks in vivo.
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Direct Administration Techniques
1) Bath Immersion
2) Embryonic Microinjection
3) Oral Administration
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Targeted Drug Delivery Systems
1) Genetic Manipulation Techniques
2) Nanoparticles
3) Hydrogels
Advantages
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Zebrafish embryos progress through their developmental stages swiftly.
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Allows live imaging at the organism level.
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Powerful genetic tools.
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High-throughput drug screening.
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Effective screening of various compounds at different developmental stages.
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It provides valuable in vivo systems for studying the biological distribution and pharmacokinetics of candidate drugs.
Frequently Asked Questions
What roles do zebrafish models play in drug development and discovery?
Zebrafish models play a significant role in drug development and discovery due to their unique characteristics and advantages. Here are some key points:
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Genetic Similarity: Zebrafish have a high degree of genetic similarity with humans, making them valuable models for studying human diseases.
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Genetic Manipulability: Their genomes can be easily manipulated, allowing researchers to create specific disease models and study the effects of genetic mutations.
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Transparent: Transparent zebrafish embryos allow for real-time visualization of developmental processes and drug effects.
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High Fecundity: They produce a large number of offspring, which is ideal for high-throughput screening and statistical analysis.
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Cost-Effective: Zebrafish are relatively inexpensive to maintain and use in large-scale studies, reducing the overall cost of drug discovery.
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Rapid Development: Their short life cycle allows for quicker generation of results compared to traditional mammalian models.
These attributes make zebrafish an invaluable tool for identifying and validating new drug candidates, understanding disease mechanisms, and predicting potential side effects before moving to clinical trials.
What are the research applications of zebrafish in the field of probiotics?
Zebrafish are widely used in probiotic research due to their unique characteristics and similarities to humans. Here are some key research applications:
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Gut Microbiota Studies: Zebrafish are used to study the interactions between gut microbiota and the host. Their transparent embryos and larvae allow researchers to observe these interactions in real-time.
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Probiotic Effects on Health: Researchers use zebrafish to investigate the effects of probiotics on health, including immune response, gut morphology, and disease resistance.
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Metabolic Studies: Zebrafish models help study the impact of probiotics on metabolism, such as glucose homeostasis, lipid metabolism, and nutrient absorption.
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Disease Models: Zebrafish are used to create disease models to study the effects of probiotics on conditions like inflammatory bowel disease (IBD) and other gastrointestinal disorders.
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Reproduction and Development: Studies have shown that probiotics can improve fecundity and reproductive health in zebrafish, which can be extrapolated to other vertebrates, including humans.
These applications make zebrafish a valuable model for understanding the potential benefits of probiotics in health and disease.
The translatability of research results obtained from zebrafish studies and the broad prospects for human disease modeling pave the way for the development of tailored treatment strategies. Creative Biolabs' advanced probiotic technology platform and zebrafish models platform, together with our multi-professional background scientists, can well formulate reasonable solutions according to customer needs, if you have a project involved in this field, please feel free to contact us for more research ideas.
Reference
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Ochenkowska, Katarzyna, Aveeva Herold, and Éric Samarut. "Zebrafish is a powerful tool for precision medicine approaches to neurological disorders." Frontiers in Molecular Neuroscience 15 (2022): 944693. Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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