Zebrafish Model related Service for Drug Efficacy Evaluation
Background Services Advantages FAQs
Background
Zebrafish has become an increasingly accepted model organism for biomedical research, capable of comprehensively analyzing the unique functions of genes and their signaling pathways during development and neurodegenerative processes. In different fields of biomedical research, including immunology, toxicology, cancer, and behavioral biology, they have become multifunctional animal models with strong potential to serve as whole animal models for preclinical biological assays in drug development processes. Zebrafish, as a potentially attractive model in the field of neurodegenerative diseases, can be used to develop therapeutic interventions for Alzheimer's disease. The zebrafish model provides an excellent opportunity for screening neural-specific compounds due to the feasibility of high-throughput screening and its advantages similar to mammals. In addition, it has also been successfully utilized to enhance our understanding of the mechanisms by which neutrophils play a role in inflammatory diseases.
Fig.1 Zebrafish served as a rapid means for phenotype-based high-throughput drug screening.1,3
Drug Efficacy Screening Services
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Neuro-Specific Drug Discovery
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Anti-Inflammatory drug discovery
Wounding-Induced Inflammation Model
Chemical-Induced Inflammation Model
Mutation-Induced Inflammation Model
These zebrafish inflammation models have proven to be very useful in revealing molecular and cellular aspects of the inflammatory response and in discovering new drug targets, are effective screening tools for drug candidates, and have great potential to accelerate the development of anti-inflammatory drugs in preclinical stages.
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Anti-Microbial Drug Discovery
Zebrafish embryo infection models are commonly used to evaluate two essential characteristics of potential antimicrobial agents: in vivo toxicity and in vivo activity. They are valuable tools for predicting the activity of antimicrobial compounds and mitigating early failures in drug development.
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Cancer Drugs Screening
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Anti-Virus Drugs Screening
Advantages of Zebrafish Models
Phenotypic and cost-effective whole organism chemical screening in zebrafish has multiple advantages, including the potential to identify disease-modifying drugs without knowing effective targets, identify compounds with multi-pharmacological effects, and simultaneously evaluate the efficacy, toxicity, biodistribution, and pharmacokinetics of compounds in vertebrate model systems.
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Immune system
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Easy handling, large number of data
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The similarities of its molecular pathways and physiology with that of humans
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High fecundity
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Rapid embryonic development
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Fully sequenced genome
Frequently Asked Questions
Can the zebrafish model be used to evaluate drug efficacy?
Yes, zebrafish models are indeed used to evaluate drug efficacy. They offer several advantages, such as high genetic similarity to humans, genetic manipulability, and transparent embryos that allow for easy observation of developmental processes. Zebrafish are used in various stages of drug discovery and development, including phenotype-based drug development, structure-activity relationship studies, target-based drug development, and toxicity testing. They are particularly useful for preclinical safety and efficacy studies.
Could the zebrafish be used to evaluate live biotherapeutics?
Yes, zebrafish can be used to evaluate live biotherapeutics. Their transparent embryos and larvae allow for real-time, non-invasive imaging, making them an excellent model for studying the effects of live biotherapeutics on various biological processes. Researchers have used zebrafish models to study the efficacy and toxicity of different biotherapeutics, including those aimed at treating cancer, metabolic diseases, and other conditions. The zebrafish model provides a cost-effective and efficient platform for high-throughput screening and detailed mechanistic studies.
Can the zebrafish be used to study probiotic drugs?
Absolutely. Zebrafish are a valuable model for studying probiotic drugs. Their transparent embryos and larvae allow researchers to observe the effects of probiotics on gut microbiota and overall health in real-time. Studies have shown that zebrafish can be used to evaluate the immunomodulatory and histological effects of probiotics. For instance, research has demonstrated that probiotics like Lactobacillus delbrueckii and Lactobacillus acidophilus can improve gut health and immune responses in zebrafish infected with pathogens.2,3
If you have more specific research or application of probiotics and live biotherapeutics in zebrafish, please do not hesitate to contact us, the technical team at Creative Biolabs will be happy to help you with a one-stop solution to accelerate your projects.
References
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Lee, Hung-Chieh, Cheng-Yung Lin, and Huai-Jen Tsai. "Zebrafish, an in vivo platform to screen drugs and proteins for biomedical use." Pharmaceuticals 14.6 (2021): 500.
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Ehsannia, Sheida, et al. "Effects of probiotics on Zebrafish model infected with Aeromonas hydrophila: spatial distribution, antimicrobial, and histopathological investigation." BMC microbiology 22.1 (2022): 167.
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Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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