Technology
Creative Biolabs is a CRO company with extensive project experience in a variety of fields. At present, our probiotic technology platform has been very mature and has served many customers in the field of probiotics from biotechnology, medicine, and academic research institutions.
Overview
The research on probiotic microorganisms is an extremely active field with an impact not only on human and animal health but also on the food and pharmaceutical industries. To provide multiple novel beneficial activities, and to displace deleterious microbes and their activities, modification of the microbiome via the introduction of new bacteria is a rational drug-development approach. The research leading to the characterization, quantification, and functional attribution of the microbes throughout the human body has led to many drug-development programs. Animal studies provide a valid model for studying human physiology and disease, and preclinical trials remain essential to understanding the molecular mechanisms underlying the onset of many diseases.
Assessment for Next-generation Probiotics (NGPs)
NGPs are attracting more and more interest both at academic and industrial research levels. First of all, wider and more thorough studies about the safety and tolerability of these novel microbial taxa need to be carried out. A thorough characterization of several strains from these new species will be required, including phenotypic and genomic analyses, with a focus on the research for the presence of genes related to antibiotic resistance, toxin production, virulence factors, and mobile elements. In vitro and in vivo trials, as well as genomic screening, are needed, to understand the functional mechanisms leading to a positive effect on human health. In addition, the viability of the strains after the gastrointestinal passage should also be evaluated, as well as the number of cells to be assumed to obtain the desired effects.
Fig.1 A schematic diagram of workflow on the precise application of NGP. (Luo, 2022)
Technologies at Creative Biolabs
Creative Biolabs has focused on the field of probiotic research for many years, and we have established a comprehensive advanced technology platform with the necessary expertise and ability to individually evaluate probiotic strains and probiotic products. The following technology list is constantly updated, if you do not find what you need, please contact us directly, and we can help you customize the solution according to the project.
Creative Biolabs provides a comprehensive technology platform for evaluating the next generation of probiotics from multiple perspectives, and our team of highly qualified and experienced technicians will work with you to develop and deliver testing and analysis solutions. We will work with you as part of your team, not only to provide you with comprehensive quality data but also to provide timely and effective solutions to any challenges you face. Contact us to find out how we can technically support your project.
Reference
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Luo, Y.; et al. Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges. npj Biofilms and Microbiomes. 2022, 8(1): 1-11.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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