Engineering Bacillus velezensis Services for Live Biotherapeutics Drug Discovery
Background Services Advantages FAQs Resources
Background
Bacillus velezensis (B. velezensis) is a new species of the Bacillus family discovered in recent years and is also an emerging candidate for probiotics. It is often used as a direct-feeding microorganism in animal feed but is rarely used as a probiotic in humans. Several strains of B. velezensis were isolated from human stool and cervicovaginal samples, suggesting that B. velezensis naturally exists in the human gut and vaginal microbiota. Some studies have reported the application of B. velezensis as a probiotic in aquaculture, which has the potential to promote plant growth and inhibit plant pathogenic fungi. It has shown good results in controlling destructive plant pathogens and biocides production. B. velezensis strains secrete a wide range of bioactive molecules, including antimicrobial metabolites such as macro prolactin, antimicrobial lipopeptides, and digestive enzymes. As a result, strains of the bacterium are also widely and safely used as probiotics in animal feed and aquaculture additives. The genus B. velezensis remains a promising resource for the development of novel probiotics.
Engineering B. velezensis Services
Services
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Gene knock-out
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Gene knock-in/Gene insertion
Deliverables
Engineered strain in glycerol stock
Quality Control
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Sequencing Validation
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Western Blot Validation (Optional)
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or cell-based assay of your interest.
Delivery Time
Starting from 4-6 weeks.
Materials from Clients
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Overall construction scheme.
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Host strain.
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Target gene name.
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Target gene sequence. (If the whole genome sequence is unavailable.)
How B. velezensis Strain Construction Service Can Assist Your Project
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Construct the target strains according to the needs of clients or referring to the published scheme.
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Optimize the program to improve the success rate.
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Delivery of the constructed target strains (knockout or integrated).
Advantages
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B. velezensis can be used as an effective alternative to synthetic pesticides by utilizing the bacteria themselves or extracting their active compounds and may be a versatile and powerful biocontrol agent.
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Several isolates were identified to harbor a large number of biosynthetic gene clusters encoding gene products for the production of secondary metabolites.
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B. velezensis has been listed by the European Food Safety Authority (EFSA) in the approved QPS.
Frequently Asked Questions
What are the applications of B. velezensis as a potential probiotic?
B.
velezensis has several promising applications as a probiotic:
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Gut Health: It supports a healthy gut flora and aids digestion and nutrient absorption.
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Support Immunity: Helps the body fight off infections and strengthens the immune system.
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Antimicrobial Properties: Produces compounds that can inhibit harmful pathogens, promoting overall health.
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Animal Feed Additive: Improve intestinal health and growth performance of livestock.
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Plant Growth Promotion: Enhances plant growth and defense responses, making it useful in agriculture.
These applications make
B.
velezensis a versatile and valuable probiotic for both human and animal health, as well as agricultural use.
Can B. velezensis be engineered?
Yes, B. velezensis can be genetically engineered. Researchers have been exploring its genetic characteristics and potential applications through various studies. For instance, the gene-editing system has been used to introduce specific genetic modifications in B. velezensis to enhance its biocontrol properties and antimicrobial activities. Genetic engineering can help improve its efficacy as a probiotic, biocontrol agent, and plant growth promoter by optimizing its metabolic pathways and enhancing its ability to produce beneficial compounds like lipopeptides.
Resources
Creative Biolabs specializes in providing customized services to our clients, so if you are working on research related to B. velezensis, please do not hesitate to contact our technical team, we will be happy to assist you in your research journey.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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