Live Biotherapeutics Drug Discovery Services for Neurologic/Psychiatric Disorders
Basic science studies have shown some efficacy of probiotics on central nervous system function regulation. Probiotics have positive modulatory effects on brain function including the normalization of anxiety and depression-like behavior through the gut-brain axis. Creative Biolabs has a management team with an average of 10+ years of next-generation probiotics (NGPs) industry experience. Our staff has the operational grit and scientific background about NGPs' discovery and analyses to promote your success.
Fig.1 Communication between the gut microbiota and the brain.1
Common Neuropsychiatric Disorders
Anxiety and Depression
A new group of probiotics, named psychobiotics are used to improve the cognitive functions in patients with psychiatric illness. Many distinct gut microbial species produce diverse neuro-molecules involved in mood regulation, which affects host physiology. Human and animal studies of probiotics show similar reductions in anxiety and depression symptoms.
Autism Spectrum Disorder (ASD)
ASD constitutes a group of brain developmental disorders. It is urgent to look for risk-free and effective treatments. Accumulating evidence showed modulation of the gut microbiota is a potential therapy in children with ASD.
Alzheimer's Disease (AD)
Earlier studies have reported on associations between the composition of the gut microbiome and certain biomarkers of immune activation and inflammation in patients with cognitive impairment (AD and mild cognitive impairment). Moreover, probiotics have been shown in earlier studies to influence tryptophan metabolism and immunological regulatory circuits with no obvious side effects.
Parkinson's Disease (PD)
Probiotics might be a powerful tool to alter PD-associated microbiota composition, improve GI function, and therefore reduce gut leakiness and bacterial translocation.
Amyotrophic Lateral Sclerosis (ALS)
Gut microbiome is modifiable, making it an attractive therapeutic candidat. Several studies have shown promising results after intervention of microbial derived metabolites in either experimental ALS or human ALS.
Epilepsy
The gut microbiota regulates immunity and inflammation, metabolism, and peripheral and central neuronal signaling pathways independently associated with epileptogenesis. It is increasingly recognized as an important factor in epileptogenesis.
Stroke
Pharmacological and non-pharmacological treatments for stroke are critical but can be expensive or harmful, and probiotics, as a promising alternative therapy, may be a beneficial component of rehabilitation programs for patients after stroke.
Multiple Sclerosis
Gut microbiological balance can be maintained in MS patients through probiotic strains by reducing inflammatory responses.
Huntington's Disease
Multiple lines of evidence pointing to gut dysbiosis as a probable cause of Huntington's Disease (HD). Metabolites of microorganisms have the potential to modulate the pathogenesis of HD.
Probiotic Drug Discovery Services at Creative Biolabs
Creative Biolabs has developed an unparalleled platform for NGP isolation, identification, and functional characterization. Currently, we have discovered a wide range of potential NGPs. Moreover, our specialized techniques and methods are specifically catered to support your NGPs' analytics needs to guarantee safety and efficiency.
Creative Biolabs strives to retain our customers through competitive cost, strong communication, timeliness, and responsive programs. We desire to work closely with our clients to achieve long-term mutually beneficial relationships. If you want to experience our services and products, please feel free to contact us for more information.
Reference
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Spielman, Lindsay Joy, Deanna Lynn Gibson, and Andis Klegeris. "Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases." Neurochemistry international 120 (2018): 149-163.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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