Live Biotherapeutics Drug Discovery Services for Neurologic/Psychiatric Disorders
Basic science studies have shown some efficacy of probiotics on central nervous system function regulation. Probiotics have positive modulatory effects on brain function including the normalization of anxiety and depression-like behavior through the gut-brain axis. Creative Biolabs has a management team with an average of 10+ years of next-generation probiotics (NGPs) industry experience. Our staff has the operational grit and scientific background about NGPs' discovery and analyses to promote your success.
Fig.1 Communication between the gut microbiota and the brain. (Spielman, 2018)
A new group of probiotics, named psychobiotics are used to improve the cognitive functions in patients with psychiatric illness. Many distinct gut microbial species produce diverse neuro-molecules involved in mood regulation, which affects host physiology. The consumption of yogurt containing Lactobacillus casei (L. casei) Shirota improved the mood of healthy individuals. Another similar study reported that a group of forty healthy young adults showed a significant reduction in overall cognitive reactivity to depression as well as ruminative and aggressive thoughts after consuming a probiotic mixture for 4 weeks.
Human and animal studies of probiotics show similar reductions in anxiety and depression symptoms. Human patients suffering from chronic stress were given a three-week probiotic treatment containing Bifidobacteria species. Subjects in the bottom third of the elated/depressed scale demonstrated the most improvement with treatment. These patients rated an overall happier mood on daily analog scales using six dimensions of mood including energetic/tired, composed/anxious, elated/depressed, clearheaded/muddled, confident/unsure, and agreeable/angry.
ASD constitutes a group of brain developmental disorders. It is defined by stereotyped behavior and deficits in communication and social interaction. Evidence demonstrates that gastrointestinal (GI) symptoms, such as abdominal pain, gaseousness, diarrhea, constipation, and flatulence, are a common comorbidity in patients with ASD. Parents often take their children to receive intervention that is tailored to their specific needs. It is urgent to look for risk-free and effective treatments. Accumulating evidence showed modulation of the gut microbiota is a potential therapy in children with ASD.
The pathology of AD is complex and it has been a growing global challenge. Earlier studies have reported on associations between the composition of the gut microbiome and certain biomarkers of immune activation and inflammation in patients with cognitive impairment (AD and mild cognitive impairment). Moreover, probiotics have been shown in earlier studies to influence tryptophan metabolism and immunological regulatory circuits with no obvious side effects, e.g., patients with liver cirrhosis and AD.
PD is a complex neurological disorder classically characterized by impairments in motor system function associated with the loss of dopaminergic neurons in the substantia nigra. PD stands in second place after AD among common neurodegenerative disorders.
Probiotics might be a powerful tool to alter PD-associated microbiota composition, improve GI function, and therefore reduce gut leakiness and bacterial translocation. Patients with PD suffering from chronic constipation received fermented milk containing L. casei Shirota for five weeks and showed improved stool consistency and reduced bloating and abdominal pain. Besides dairy products, non-dairy products in form of tablet have been shown capable of reducing abdominal pain and bloating in patients with PD.
Probiotic Drug Discovery Services at Creative Biolabs
Creative Biolabs has developed an unparalleled platform for NGP isolation, identification, and functional characterization. Currently, we have discovered a wide range of potential NGPs. Moreover, our specialized techniques and methods are specifically catered to support your NGPs' analytics needs to guarantee safety and efficiency.
Creative Biolabs strives to retain our customers through competitive cost, strong communication, timeliness, and responsive programs. We desire to work closely with our clients to achieve long-term mutually beneficial relationships. If you want to experience our services and products, please feel free to contact us for more information.
Reference
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Spielman, L.J.; et al. Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases. Neurochem. Int. 2018, (120): 149-163.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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