Live Biotherapeutics Drug Discovery Service for Epilepsy
Creative Biolabs is a leading contract research organization (CRO) in the United States that provides standard and customized testing services for live biotherapeutic research. We have rich project experience. Our mission is to advance client projects by providing special, customized probiotic research services.
Overview
Epilepsy is a devastating neurological disorder that can cause unpredictable and uncontrollable seizures in patients of all ages. Since the microbiome is closely related to autoimmunity, the specific composition of the gut microbiome may influence an individual's susceptibility to epilepsy and subsequent disease progression. Studies have shown that intestinal flora imbalance plays a pathological role in the occurrence and development of epilepsy, so it may become a safer therapeutic target for epilepsy.
Fig.1 Potential therapies for epilepsy based on gut microbiota.1
Microbiota and Epilepsy
Gut microbiota is an important factor in the biotransformation of xenobiotics, including drugs.
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Immune and Inflammation Pathways
1. Gut Immunity
Gut microbiota can also be involved in the pathogenesis of autoimmune diseases. It can regulate the occurrence and development of epilepsy by regulating inflammatory mechanisms, adaptive immunity, and innate immunity. Therefore, the role of specific autoimmune mechanisms and their associated pathogenic autoantibodies in seizures has attracted increasing attention.
2. Gut Barrier and Blood-Brain Barrier
The intestinal mucosal barrier and blood-brain barrier (BBB) work together to prevent intestinal flora and its secretions from entering the brain.
3. Neuroimmunity
Intestinal microorganisms metabolize dietary tryptophan into aromatic hydrocarbon receptor agonists and interact with their receptors to control the activation of microglia and the expression of TGF-a and VEGF-B, thereby regulating the pathogenic activity of astrocytes.
Fig.2 Supposed mechanisms and effects of prebiotics and probiotics in epilepsy.2
Neuropodocytes use glutamate as a neurotransmitter to connect the gut lumen to the brainstem, synaptically transmitting the gut lumen signal to the vagus nerve. They provide strong theoretical support for the treatment of nervous system diseases by regulating intestinal flora.
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Enteroendocrine Signaling and Microbial Metabolites
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The HPA Axis
Gut microbiota can affect hypothalamic function through changes in circulating cytokine levels or other pathways, thereby regulating the HPA axis.
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar Epilepsy Research
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Research Article
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Available Services
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Beneficial effects of probiotic Bifidobacterium longum in a lithium-pilocarpine model of temporal lobe epilepsy in rats.3
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Probiotic preparation and treatment
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mRNA expression analysis
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Behavioral tests
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Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of acute seizure.4
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Probiotic preparation
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Serum biochemical analysis
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Fecal short-chain fatty acid (SCFA) measurement
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Fecal gDNA extraction and sequencing analysis
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Gut microbiota in canine idiopathic epilepsy: effects of disease and treatment.5
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Sequencing of bacterial 16S rRNA gene
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Faecal microbiota analysis
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Creative Biolabs aims to become the most trusted provider of live biotherapeutics and probiotic solutions, supporting scientific discovery by providing high-precision and cost-effective services and products to researchers worldwide. Please feel free to contact us for more details.
References
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Ding, Manqiu, et al. "Microbiota gut-brain axis and epilepsy: a review on mechanisms and potential therapeutics." Frontiers in Immunology 12 (2021): 742449.
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Iannone, Luigi Francesco, et al. "Gut microbiota manipulation as an epilepsy treatment." Neurobiology of Disease 174 (2022): 105897.
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Zubareva, Olga E., et al. "Beneficial Effects of Probiotic Bifidobacterium longum in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy in Rats." International Journal of Molecular Sciences 24.9 (2023): 8451.
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Eor, Ju Young, et al. "Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure." Epilepsy Research 169 (2021): 106506.
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García-Belenguer, Sylvia, et al. "Gut microbiota in canine idiopathic epilepsy: effects of disease and treatment." Animals 11.11 (2021): 3121.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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