Parabacteroides spp. as Next Generation Probiotics

The potential of bacteriotherapy for the treatment of different conditions is becoming more evident. Strains of human gut inhabitants have shown several interesting bioactivities and are thus currently being considered as food supplements or as live biotherapeutics. As one of the largest live biotherapeutic products (LBP) services suppliers, Creative Biolabs has expertise and capabilities in providing high-quality LBP solutions.

Introduction of Parabacteroides spp.

As with several other new genera reclassified from the initially broad genus Bacteroides fragilis group, including Alistipes, Parabacteroides is a relatively new genus with distinctive features shared among other gut commensal bacteria. According to the NCBI, the full taxonomy lineage for the genus Parabacteroides is Bacteria; FCB group; Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides. As of May 1, 2021, the Parabacteroides genus (taxonomy ID: 375,288) comprises 15 species. It is a Gram-negative, obligately anaerobic, non-spore-forming. non-motile and rod-shaped genus. Colonies on EG agar plates are 1-2 mm in diameter, grey to off-white-grey, circular, entire, slightly convex, and smooth. Members of the genera Bacteroides and Parabacteroides in the order Bacteroidales are known to make up 14 to 40% of cultivable microorganisms in human feces. Due to their high prevalence in the gut and fecal microbiota, Bacteroides spp. and Parabacteroides spp. have been considered to be clinically important anaerobes that are related to gastrointestinal well-being.

Exclusively breastfed infant microbiota develops over time. Fig.1 Exclusively breastfed infant microbiota develops over time. (Cheema, 2022)

Parabacteroides spp. for Disease Treatment

The commensal Parabacteroides isolates with anti-inflammatory and epithelium enhancing capacity are potential candidates for bacteriotherapeutic applications aiming to restore gut homeostasis. Besides relating to gastrointestinal functioning, certain Parabacteroides spp. are also suspected to be human gut specific and can act as biomarkers for identifying fecal pollutants from human and nonhuman sources.

Parabacteroides goldsteinii has exhibited great potential to be a probiotic against obesity. Oral administration of live Parabacteroides goldsteinii significantly reduced the weight gain and visceral fat, maintained intestinal integrity, and increased adipose tissue thermogenesis, exhibiting therapeutic effects on obesity and metabolic disorders in the obesity mice model.

Parabacteroides distasonis is a member of the gut core microbiome that brings many beneficial properties to its host, in the metabolic, immune, and intestinal inflammation aspects.

Graphical summary of probiotic impact in the gut epithelium of host.Fig.2 Graphical summary of probiotic impact in the gut epithelium of host. (Andrade, 2020)

What Services Can We Provide for Parabacteroides spp. at Creative Biolabs?

Parabacteroides spp. Related Products at Creative Biolabs

  • Strain Products

We supply a variety of Parabacteroides spp. strains of different preservation numbers as below. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs is a customer-driven organization that is oriented toward quick knowledgeable responses to your LBP development needs. You can rely on our know-how, understanding, experience, and passion for providing the best quality services and products, reliably with quick turnaround times and the utmost respect for customer confidentiality. Please feel free to contact us for further discussion with Parabacteroides spp. Related services or products.

References

  1. Cheema, A.S.; et al. Exclusively Breastfed Infant Microbiota Develops over Time and Is Associated with Human Milk Oligosaccharide Intakes. International Journal of Molecular Sciences. 2022, 23(5): 2804.
  2. Andrade, J.C.; et al. Commensal obligate anaerobic bacteria and health: production, storage, and delivery strategies. Frontiers in Bioengineering and Biotechnology. 2020, 8: 550.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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