Blautia faecis (B. faecis) DSM33383 could be developed as a therapeutic drug, either through its supernatant, isolated bioactive compounds, or as a Live Biotherapeutic Product (LBP). Creative Biolabs has 10+ years of experience providing CRO services with a skilled team of scientists who will work with you in developing your probiotic of interest.
B. faecis cells are Gram-stain-positive, strictly anaerobic, nonmotile coccobacilli that are 1.0-2.3×0.5-0.8 mm in size. After 72 h at 37℃ on GAM agar, cells are non-spore-forming, circular, umbonate, pale grey opaque colonies with intact edges. Catalase and oxidase activity tests are negative. The type of strain, M25T (=KCTC 5980T=JCM 17205T) was isolated from human faeces. The G+C content of the genomic DNA of the type of strain is 41.6 mol%. Comparative 16S rRNA gene sequencing showed that strain M25T was closely related to Ruminococcus obeum and Blautia glucerasea HFTH-1T (96.17%) within the family Lachnospiraceae. For future commercial product development, a B. faecis strain like DSM33383 should not be considered conventional probiotics.
The researchers have identified the B. faecis DSM33383 strain, which decreased the TNF-induced production of IL-8 by the intestinal epithelial cell line HT-29. The beneficial effects of this strain were further studied in two preclinical models following influenza. The intragastrical administration of B. faecis DSM33383 led to protection in influenza-infected mice suffering from an Streptococcus pneumoniae (S.p) and, to a lesser extent, from a Salmonella enterica serovar Typhimurium (S.t) secondary infection. This study suggested that B. faecis DSM33383 may be a promising candidate for the prevention and management of respiratory infectious diseases.
Fig.1 Effect of B. faecis DSM33383 supplementation during IAV infection on secondary Streptococcus pneumoniae infection. (Verstraeten, 2022)
We supply a variety of B. faecis strains of different preservation numbers. If you need other strains, please contact us.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.