Lactobacillus paracasei as Next Generation Probiotics

Lactobacillus paracasei (L. paracasei) is one strain with powerful benefits. It has great potential in the treatment of the diseases and can be a good candidate strain of live biotherapeutic products (LBP). Creative Biolabs has been engaged in LBP research for more than 10 years. We have built an advanced technology platform and accumulated rich LBP project experience.

Introduction of L. paracasei

L. paracasei is a species of lactic acid bacteria often used in fermented dairy and vegetable products and it is hosted in the human intestinal tract and mouth as a beneficial bacterium with health benefits. L. paracasei is a short or long rod-shaped pleomorphic bacillus with different lengths and generally less than 1.5 μm in width. Gram-positive staining, no motility, no spore production. It is reported to strengthen the immune system and may increase the production of cytokines, making children less susceptible to common infections. In addition, it has been shown to promote natural killer cell activity, lymphocyte proliferation, and antibody production. As a result, it improved symptoms of influenza virus infection in mice, improved survival in mice infected with E. coli, and has anti-inflammatory effects.

Scanning electron microscope image of <em>L. paracasei</em> MK1 (×30,000). (Lee, 2013) Fig.1 Scanning electron microscope image of L. paracasei MK1 (×30,000). (Lee, 2013)

L. paracasei for Disease Treatment

Disruption of the intestinal microflora is considered one of the main causes of the disease. L. paracasei subsp. paracasei NTU 101 (NTU 101) is a multifunctional strain with anti-inflammatory and regulatory effects on intestinal bacteria associated with the pathogenesis of IBD. Scientists investigated the effects of NTU 101 on dextran sulfate sodium (DSS)-induced colitis in a mouse model. Results showed that NTU 101 powder improved antioxidant capacity, decreased pro-inflammatory cytokine levels, increased anti-inflammatory cytokine levels, and slightly improved weight loss in DSS-treated mice during the last days of the study. This suggested that NTU 101 powder could alleviate the clinical symptoms of DSS-induced colitis in mice.

The possible pathways of relieving symptoms. Fig.2 The possible pathways of relieving symptoms. (Chen, 2019)

Probiotics are considered an option for the prevention of type 2 diabetes mellitus (T2DM). Studies have shown that the administration of L. paracasei TD062 can regulate fasting blood glucose (FBG), postprandial blood glucose (PBG), glucose tolerance, liver glycogen, and lipid metabolism levels. In addition, L. paracasei TD062 was found to have a positive effect on the gene expression levels of glucose metabolism-related to and PI3K/Akt pathway. These results demonstrated that L. paracasei TD062 played an important role in preventing the development of T2DM. These findings supported that L. paracasei TD062 could be a promising application for the treatment of T2DM.

What Services Can We Provide for L. paracasei at Creative Biolabs?

L. paracasei Related Products at Creative Biolabs

  • Strain Products

We supply a variety of L. paracasei strains of different preservation numbers as below. If you need other strains, please contact us.

CAT Product Name Product Overview
LBP-005FG Lactobacillus paracasei Powder Freeze-dried L. paracasei powder.
LBP-014FG Lactobacillus paracasei Powder Freeze-dried L. paracasei powder.
LBST-149FG Lactobacillus paracasei; 192210 L. paracasei was isolated from fermented yak milk. It is a Gram-positive, homofermentative species of lactic acid bacteria that are commonly used in dairy product fermentation and as probiotic cultures.
LBST-150FG Lactobacillus paracasei; 354789 L. paracasei is a Gram-positive, homofermentative species of lactic acid bacteria that are commonly used in dairy product fermentation and as probiotic cultures.
  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs, a leading CRO company in the LBP industry in the United States, has a team of senior technical experts with experience in the research of a variety of probiotics. We are very enthusiastic to discuss your problems and find the most appropriate solutions for you. If you are interested in our L. paracasei related products and services, please contact us for further discussion.

References

  1. Lee, S.; et al. Optimization of soymilk fermentation by the protease-producing Lactobacillus paracasei. Korean Journal of Food Science and Technology. 2013, 45(5): 571-577.
  2. Chen, C.L.; et al. Therapeutic effects of Lactobacillus paracasei subsp. paracasei NTU 101 powder on dextran sulfate sodium-induced colitis in mice. Journal of Food and Drug Analysis. 2019, 27(1): 83-92.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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