Lactobacillus delbrueckii as Next Generation Probiotics
Background L. delbrueckii and Diseases Services Products Brochures FAQs Resources
Introduction of L. delbrueckii
Lactobacillus delbrueckii (L. delbrueckii) is a kind of bacteria in the Lactobacillaceae family. It is part of the microbiota of the female lower reproductive tract. In the role as a probiotic, it may help produce a better vaccination response and greater resistance to various infectious diseases.
Introduction of L. delbrueckii
L. delbrueckii are the important industrial lactic acid bacteria with Gram-positive, facultative anaerobic, non-motile, non-spore, rod-shaped, and cell size range = 0.5-0.8 x 2.0-9.0 mm. Like other lactic acid bacteria, L. delbrueckii has acid resistance, cannot synthesize porphyrin, and have strict fermentation metabolism, with lactic acid as the main metabolic end product. There are three subspecies of L. delbrueckii: subsp. delbrueckii, subsp. lactis, and subsp. bulgaricus. Among them, L. delbrueckii subsp. bulgaricus is one of the most widely used thermophilic starter strains in the production of industrial fermented dairy products, and it grows on relatively limited carbohydrates and usually need pantothenic and niacin.
Benefit of L. delbrueckii in Diseases
L. delbrueckii subsp. bulgaricus has been used to ferment milk for many centuries. Many researchers have shown various beneficial effects for this bacterial species in the treatment of diseases.
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Diseases
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Functions of L. delbrueckii
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Gastrointestinal Disorders
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Although living probiotics can significantly regulate the immune and barrier functions of the intestinal tract, studies have shown that the DNA of probiotics has immunomodulatory effect, which indicates that the isolated probiotic DNA can effectively alleviate intestinal inflammation, just like the treatment of live bacteria. An analysis of reliable sources of probiotics has shown that bacterium, such as L. delbrueckii subsp. bulgaricus, can help treat gastrointestinal diseases such as inflammatory bowel disease (IBD) and Crohn's disease.
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Systemic Immune Disease
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In the whole process of life, the immune system will age, resulting in the damage of its defense ability, making some diseases follow. Preventing or delaying this deterioration is considered to be essential for maintaining overall health and prolonging life expectancy. One study evaluated whether adding L. delbrueckii subsp. bulgaricus to the diet can enhance the immune response in the elderly. The results suggest that the L. delbrueckii subsp. bulgaricus may help to maintain an appropriate immune response, mainly by slowing down the aging of T cell subsets and increasing the number of immature T cells that may respond to new antigens.
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Neurologic/Psychiatric Disorders
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An analysis of reliable sources from animal studies suggests that L. delbrueckii subsp. bulgaricus may help manage a variety of mental health conditions, which may include attention deficit hyperactivity disorder (ADHD) and depression.
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Our Drug Discovery Service of L. delbrueckii
The role of probiotics seems promising in the prevention or treatment of diseases. As a service provider with rich experience in the field of bacteria and drug development, Creative Biolabs is committed to developing a one-stop service for a variety of probiotic drugs.
For probiotics L. delbrueckii, we can provide many services, including but not limited to:
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A comprehensive systematic identification
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Multiple biosafety tests
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Downstream processing optimization and development
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Lab-scale Production
If you are interested in our services and products, please feel free to contact us for more information.
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FAQs
How is Lactobacillus delbrueckii cultivated and maintained for research purposes?
Lactobacillus delbrueckii is cultivated under specific anaerobic conditions, using nutrient-rich media to ensure optimal growth and viability. The maintenance involves regular sub-culturing and cryopreservation techniques to preserve its beneficial properties and genetic stability over time.
What makes Lactobacillus delbrueckii a suitable candidate for studying gastrointestinal health?
Lactobacillus delbrueckii exhibits robust adherence to intestinal mucosa, competitive exclusion of pathogens, and modulation of the host's immune system. These characteristics make it an excellent model for studying gastrointestinal health, particularly in understanding host-microbe interactions and probiotic efficacy.
Can Lactobacillus delbrueckii be genetically modified for enhanced probiotic effects?
Yes, Lactobacillus delbrueckii can be genetically modified to enhance its probiotic effects, such as improving its survival in the gastrointestinal tract or increasing its production of beneficial metabolites. Genetic engineering approaches are actively being explored to maximize its therapeutic potential.
How does the use of Lactobacillus delbrueckii compare to other probiotic strains in research?
Lactobacillus delbrueckii stands out due to its ability to produce large quantities of lactic acid, its stability under gastrointestinal conditions, and its well-characterized genome. Compared to other probiotic strains, it offers unique benefits in terms of both health effects and ease of use in laboratory settings.
How can the efficacy of Lactobacillus delbrueckii as a probiotic be evaluated in experimental studies?
The efficacy of Lactobacillus delbrueckii can be evaluated through in vitro and in vivo studies, focusing on parameters such as adhesion to epithelial cells, inhibition of pathogens, modulation of the immune response, and overall impact on gut microbiota composition.
Resources
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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