Lactobacillus delbrueckii as Next Generation Probiotics

Lactobacillus delbrueckii (L. delbrueckii) is a kind of bacteria in the Lactobacillaceae family. It is part of the microbiota of the female lower reproductive tract. In the role as a probiotic, it may help produce a better vaccination response and greater resistance to various infectious diseases.

Introduction of L. delbrueckii

L. delbrueckii are the important industrial lactic acid bacteria with Gram-positive, facultative anaerobic, non-motile, non-spore, rod-shaped, and cell size range = 0.5-0.8 x 2.0-9.0 mm. Like other lactic acid bacteria, L. delbrueckii has acid resistance, cannot synthesize porphyrin, and have strict fermentation metabolism, with lactic acid as the main metabolic end product. There are three subspecies of L. delbrueckii: subsp. delbrueckii, subsp. lactis, and subsp. bulgaricus. Among them, L. delbrueckii subsp. bulgaricus is one of the most widely used thermophilic starter strains in the production of industrial fermented dairy products, and it grows on relatively limited carbohydrates and usually need pantothenic and niacin.

L. delbrueckii subsp. bulgaricus. Fig.1 L. delbrueckii subsp. bulgaricus.

Benefit of L. delbrueckii in Diseases

L. delbrueckii subsp. bulgaricus has been used to ferment milk for many centuries. Many researchers have shown various beneficial effects for this bacterial species in the treatment of diseases.

Although living probiotics can significantly regulate the immune and barrier functions of the intestinal tract, studies have shown that the DNA of probiotics has immunomodulatory effect, which indicates that the isolated probiotic DNA can effectively alleviate intestinal inflammation, just like the treatment of live bacteria. An analysis of reliable sources of probiotics has shown that bacterium, such as L. delbrueckii subsp. bulgaricus, can help treat gastrointestinal diseases such as inflammatory bowel disease (IBD) and Crohn's disease.

  • Systemic Immune Disease

In the whole process of life, the immune system will age, resulting in the damage of its defense ability, making some diseases follow. Preventing or delaying this deterioration is considered to be essential for maintaining overall health and prolonging life expectancy. One study evaluated whether adding L. delbrueckii subsp. bulgaricus to the diet can enhance the immune response in the elderly. The results suggest that the L. delbrueckii subsp. bulgaricus may help to maintain an appropriate immune response, mainly by slowing down the aging of T cell subsets and increasing the number of immature T cells that may respond to new antigens.

An analysis of reliable sources from animal studies suggests that L. delbrueckii subsp. bulgaricus may help manage a variety of mental health conditions, which may include attention deficit hyperactivity disorder (ADHD) and depression.

Our Drug Discovery Service of L. delbrueckii

The role of probiotics seems promising in the prevention or treatment of diseases. As a service provider with rich experience in the field of bacteria and drug development, Creative Biolabs is committed to developing a one-stop service for a variety of probiotic drugs.

For probiotics L. delbrueckii, we can provide many services, including but not limited to:

  • A comprehensive systematic identification
  • Multiple biosafety tests
  • Downstream processing optimization and development
  • GMP scale-up services

If you are interested in our services and products, please feel free to contact us for more information.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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