Lactobacillus salivarius as Next Generation Probiotics
Background Probiotic Research Products Brochures FAQs Resources
The use of probiotic Lactobacillus salivarius as an alternative to human health improvement has attracted considerable interest all over the world. Creative Biolabs, a recognized services provider in biological drug discovery, provide a wide range of probiotic products and high-quality services for our worldwide customers.
Introduction of Lactobacillus salivarius
Lactobacillus salivarius (L. salivarius) is a well-characterized probiotic bacteria species belonging to the genus of Lactobacillus and the family of Lactobacillaceae. As a lactic acid bacterium, L. salivarius was described as early as 1953, which has been widely isolated from the gastrointestinal tract and oral cavity of humans, porcine, avian, and other animals and environments. L. salivarius is a Gram-positive, non-spore-forming bacterium with rod shape, and the optimum growth temperature is 37 ℃. The colony of L. salivarius usually presents round and milky white with a diameter of ~2 micrometers, which is similar to L. rhamnosus GG in the same genus.
L. salivarius species has been proved to be an effective probiotic, and diversity of L. salivarius strains have been identified and explored as potential alternatives for the disease treatment and live bio-therapeutic development over the past few years.
Fig.1 Colony morphology of Lactobacillus salivarius on MRS agar.1
Probiotic Research of Lactobacillus salivarius
Increasing studies have revealed a variety of beneficial effects and therapeutic properties of L. salivarius for both humans and animals, including antimicrobial effects, pathogen inhibition, inflammatory disease treatment, etc. Although the probiotic effects of L. salivarius have long been established, some mechanisms of the action remain to be revealed.
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Diseases
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Functions of L. salivarius
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Bacterial acne
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L. salivarius is capable of secret several kinds of bacteriocins, which are effective to inhibit the invasion of pathogenic bacteria, regulate the composition of intestinal microbiota, and affect the host immune system. L. salivarius has been demonstrated to fight against bacterial acne and other skin conditions by producing bacteriocin to inhibit IL-8 release.
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Gastrointestinal disorders
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L. salivarius grows well in gastric acid and bile salts environment with the ability to adhere to intestinal cells, which makes L. salivarius can easily colonize in the gastrointestinal tract and play a stable protective effect and antibacterial activity. This property is currently evaluated for the treatment of Inflammatory Bowel Disease, ulcerative colitis, and other intestinal inflammations.
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Immune modulation
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Several L. salivarius strains, have been shown to improve host immunity through inducing the expression of Interleukins (IL-6, IL-10, IL-12), reducing the secretion of pro-inflammatory cytokines, and increasing the number of lymphocytes. All these immune regulatory actions can be utilized for the development of immunologically active drugs.
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Other potential benefits
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Multiple beneficial effects of L. salivarius are being explored and revealed for both humans and animals. For humans, L. salivarius has been found to improve halitosis and exhibit a therapeutic value for pancreatic necrosis treatment. For animals, L. salivarius helps animals keep healthy and reduce the incidence of diarrhea, as well as increase yields of animals and animal products.
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Related Products
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CAT
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Product Name
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Product Overview
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Price
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LBST-145FG
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Lactobacillus salivarius, 1231
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L. salivarius was isolated from human saliva. It is a well characterized, rod-shaped, Gram-positive species of probiotic bacteria.
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Inquiry
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LBST-146FG
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Lactobacillus salivarius subsp. salicinius, CH1
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L. salivarius subsp. salicinius was isolated from the hen feces. It is a well characterized, rod-shaped, Gram-positive species of probiotic bacteria.
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Inquiry
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LBST-147FG
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Lactobacillus salivarius, CH3
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L. salivarius was isolated from the Hen intestinal. It is a well characterized, rod-shaped, Gram-positive species of probiotic bacteria.
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Inquiry
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LBST-148FG
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Lactobacillus salivarius subsp. salicinius, CH10
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L. salivarius subsp. salicinius was isolated from the hen feces. It is a well characterized, rod-shaped, Gram-positive species of probiotic bacteria.
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Inquiry
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LBSX-0522-GF5
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Lactobacillus salivarius Powder
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Freeze-dried L. salivarius Powder
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Inquiry
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LBGF-0722-GF29
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Lactobacillus salivarius, 10942
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L. salivarius was isolated from human gall. It is a well characterized, rod-shaped, Gram-positive species of probiotic bacteria.
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Inquiry
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LBGF-0722-GF94
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Lactobacillus salivarius ; 24736
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L. salivarius is a probiotic bacteria species that has been found to live in the gastrointestinal tract and exert a range of therapeutic properties including suppression of pathogenic bacteria.
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Inquiry
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Considering these favorable probiotic benefits of L. salivarius, Creative Biolabs has established a comprehensive technology platform to provide best-in-all services for the development of L. salivarius. More importantly, other various probiotic species products and services are also available for your live biotherapeutic projects.
Brochures
If you are interested, please contact us, we can customize our offering to meet your specific project needs.
FAQs
What are the key properties of L. salivarius that make it suitable for use as a next-generation probiotic in research?
L. salivarius is known for its robust ability to colonize the gastrointestinal tract, produce antimicrobial peptides, and modulate the host immune system. Its adaptability and resilience in different environments make it a promising candidate for therapeutic applications in various gastrointestinal diseases.
How can L. salivarius be used in studies related to gut microbiota modulation?
L. salivarius plays a crucial role in balancing the gut microbiota by outcompeting pathogenic bacteria and enhancing the growth of beneficial microbes. Researchers often use it in studies focusing on the prevention and treatment of dysbiosis, as well as in the development of microbiota-targeted therapies.
What are the considerations for the stability and viability of L. salivarius during storage and handling in research environments?
Ensuring the stability and viability of L. salivarius is critical for accurate research outcomes. It requires storage at low temperatures, preferably in lyophilized form, and protection from moisture and oxygen. Proper handling protocols must be followed to maintain its probiotic properties.
How does L. salivarius interact with the host immune system in research models?
L. salivarius has been shown to enhance immune responses by promoting the production of anti-inflammatory cytokines and regulating the activity of immune cells such as macrophages and dendritic cells. These interactions make it a valuable model for studying immune modulation in various diseases.
Can L. salivarius be used in conjunction with other probiotics in research studies?
Yes, L. salivarius is often used in combination with other probiotic strains to study synergistic effects on gut health and disease prevention. This approach allows researchers to explore complex interactions within the microbiome and develop multi-strain probiotic formulations.
Resources
References
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Boonma, Prapaporn, et al. "Draft genome sequences and description of Lactobacillus rhamnosus strains L31, L34, and L35." Standards in genomic sciences 9 (2014): 744-754.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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