Because L. salivarius naturally appears in saliva, breast milk, and the gut, Creative Biolabs can isolate L. salivarius from defined sources (e.g., healthy oral samples or breast milk) and screen for proprietary candidates. L. salivarius screening can be customized to prioritize bacteriocin productivity or oral-colonization–linked traits.
Lactobacillus taxonomy can be deceptively complex, so precise strain confirmation is non-negotiable. Creative Biolabs verifies L. salivarius using 16S rRNA and/or whole-genome sequencing, enabling clear genetic traceability. This also distinguishes L. salivarius from close relatives such as L. aviarius for cleaner compliance documentation.
A commercial L. salivarius candidate must remain viable through real-world stress. Creative Biolabs evaluates L. salivarius tolerance to acid and bile for GI-focused programs, and to salivary enzymes and oxidative stress for oral formats. This profiling prioritizes resilient L. salivarius strains with consistent survival curves.
A central differentiator of L. salivarius is bacteriocin output (including salivaricin-type activity) and pathogen growth inhibition potential. Creative Biolabs uses high-throughput assays to quantify L. salivarius antimicrobial activity, metabolite signatures, and functional readouts that support mechanism-facing claims for R&D positioning.
Colonization and persistence are key performance drivers for L. salivarius. Creative Biolabs measures L. salivarius adhesion to intestinal or oral epithelial models (e.g., Caco-2) and evaluates competitive exclusion against target microbes. These data help predict whether a L. salivarius strain can maintain functional presence in relevant niches.
Many L. salivarius strains are studied for immune signaling patterns, including anti-inflammatory cytokine induction such as IL-10. Creative Biolabs profiles L. salivarius using immune cell models to map cytokine signatures and inflammation-linked readouts, supporting IBD-related research directions and oral inflammation study designs.
Safety evaluation is a required milestone for L. salivarius commercialization pathways. Creative Biolabs performs antibiotic susceptibility testing and can pair it with genome-informed checks to reduce the risk of transferable resistance determinants. This strengthens the safety package for L. salivarius programs targeting regulated markets.
L. salivarius can lose viability during freeze-drying, spray drying, and long-term storage. Creative Biolabs develops protectant formulations and optimizes lyophilization parameters to preserve L. salivarius CFU through shelf-life targets. Output includes stability curves and recommended storage/packaging conditions to support scale-up readiness.
