The use of probiotic Lactobacillus salivarius as an alternative to human health improvement has attracted considerable interest all over the world. Creative Biolabs, a recognized services provider in biological drug discovery, provide a wide range of probiotic products and high-quality services for our worldwide customers.
Lactobacillus salivarius (L. salivarius) is a well-characterized probiotic bacteria species belonging to the genus of Lactobacillus and the family of Lactobacillaceae. As a lactic acid bacterium, L. salivarius was described as early as 1953, which has been widely isolated from the gastrointestinal tract and oral cavity of humans, porcine, avian, and other animals and environments. L. salivarius is a Gram-positive, non-spore-forming bacterium with rod shape, and the optimum growth temperature is 37 ℃. The colony of L. salivarius usually presents round and milky white with a diameter of ~2 micrometers, which is similar to L. rhamnosus GG in the same genus.
L. salivarius species has been proved to be an effective probiotic, and diversity of L. salivarius strains have been identified and explored as potential alternatives for the disease treatment and live bio-therapeutic development over the past few years.
Fig.1 Colony morphology of Lactobacillus salivarius on MRS agar. (Boonma, 2014)
Increasing studies have revealed a variety of beneficial effects and therapeutic properties of L. salivarius for both humans and animals, including antimicrobial effects, pathogen inhibition, inﬂammatory disease treatment, etc. Although the probiotic effects of L. salivarius have long been established, some mechanisms of the action remain to be revealed.
L. salivarius is capable of secret several kinds of bacteriocins, which are effective to inhibit the invasion of pathogenic bacteria, regulate the composition of intestinal microbiota, and affect the host immune system. L. salivarius has been demonstrated to fight against bacterial acne and other skin conditions by producing bacteriocin to inhibit IL-8 release.
L. salivarius grows well in gastric acid and bile salts environment with the ability to adhere to intestinal cells, which makes L. salivarius can easily colonize in the gastrointestinal tract and play a stable protective effect and antibacterial activity. This property is currently evaluated for the treatment of Inflammatory Bowel Disease, ulcerative colitis, and other intestinal inflammations.
Several L. salivarius strains, such as L. salivarius CECT 5713, L. salivarius FFIG71, L. salivarius UCC118, etc., have been shown to improve host immunity through inducing the expression of Interleukins (IL-6, IL-10, IL-12), reducing the secretion of pro-inflammatory cytokines, and increasing the number of lymphocytes. All these immune regulatory actions can be utilized for the development of immunologically active drugs.
Multiple beneficial effects of L. salivarius are being explored and revealed for both humans and animals. For humans, L. salivarius has been found to improve halitosis and exhibit a therapeutic value for pancreatic necrosis treatment. For animals, L. salivarius helps animals keep healthy and reduce the incidence of diarrhea, as well as increase yields of animals and animal products.
Fig.2 Screening of L. salivarius strains and the evaluation of their effects against intestinal inflammation in mice. (Zhai, 2020)
Considering these favorable probiotic benefits of L. salivarius, Creative Biolabs has established a comprehensive technology platform to provide best-in-all services for the development of L. salivarius. More importantly, other various probiotic species products and services are also available for your live biotherapeutic projects.
If you are interested, please contact us, we can customize our offering to meet your specific project needs.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.