Lactobacillus crispatus as Next Generation Probiotics

Lactobacillus crispatus (L. crispatus) is a common host in healthy poultry intestines and human vagina, and the lack of this species is associated with a high risk of infectious diseases.

Introduction of L. crispatus

L. crispatus is a rod-shaped, Gram-positive facultative anaerobic bacterium. This species is specific homotype fermentation, which means that it produces only one end product through its metabolism. It is a beneficial microbial species producing hydrogen peroxide (H₂O₂), located in vaginal secretions and vertebrate gastrointestinal tract. Due to its application in the food industry, a complete genome of L. crispatus has been obtained. Its chromosome is round and 2.04 Mb long. The content of G + C in the genome was 37% with no plasmid and there were 2022 protein genes.

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Benefit of L. crispatus in Diseases

L. crispatus is specially used in the prevention and treatment of bacterial vaginosis, characterized by the lack of lactic acid bacteria. It plays a great role in protecting the host from infection.

  • Bacterial Vaginosis

Lactobacillus plays a leading role in the vaginal microbiota of healthy women of childbearing age and protects the urogenital tract from multiple infectious sources. Chlamydia trachomatis is the main cause of worldwide sexually transmitted diseases, which can cause serious sequelae, such as pelvic inflammation, infertility, and ectopic pregnancy. In the process of studying several lactic acid bacteria, it was found that L. crispatus had a strong inhibitory effect on Chlamydia infection, mainly through the secretion of metabolites in a concentration / pH dependent manner.

In addition to its presence in the female vagina, L. crispatus can survive in the gastrointestinal tract, and its resistance to extremely low pH conditions has also been reported. It has been reported that L. crispatus is effective in colonizing and protecting the intestine from infection.

Our Drug Discovery Service of L. crispatus

In the drug development of probiotics, it is often difficult to determine which characteristics of these bacteria are necessary for the prevention and final treatment of diseases, and it is also difficult to determine the appropriate dosage, duration, and administration method. We encourage future probiotic formulations to include sources of isolation, taking into account genetic and phenotypic characteristics, for use at different body parts.

Our dedicated staff and advanced equipment enable us to determine the strain and process that is most suitable for your project development. For the development of probiotic drugs such as L. crispatus, we provide a series of detailed and comprehensive services, including strain identification, potency test, host-microbe interaction, biological test, and so on. If you are interested in our services, please feel free to contact us.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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