Lactobacillus plantarum as Next Generation Probiotics

Lactobacillus plantarum is a class of normal gut microflora that utilizes carbon sources to produce lactic acid, ethanol or acetic acid, and carbon dioxide. In the food industry, L. plantarum is a fermentative bacterium, commonly found in sauerkraut, pickles, brined olives, Korean kimchi, etc. Besides, L. plantarum is a promising probiotic for diarrhea, high cholesterol, and atopic dermatitis.

Creative Biolabs has accumulated a great deal of experience in the development of next-generation probiotics. We offer a full range of services with high quality to advance L. plantarum probiotics development, including identification and isolation of L. plantarum, safety test for L. plantarum probiotics, host-microbe interaction test, and L. plantarum probiotics cGMP manufacturing.

Introduction of L. plantarum

L. plantarum, belonging to the genus Lactobacillus, is a type of anaerobic gram-positive microorganisms. It is widespread and commonly found in many foods and feeds, such as dairy, meat, fish, must, pickled vegetables, sauerkraut, sourdoughs, and silage. It is also a natural resident of the human and animal mucosa, including the oral cavity, gastrointestinal tract, vagina. L. plantarum cells are rod-shaped with a rounded end, generally, 0.9-1.2 μm wide and 3-8 μm long, occurring singly, in pairs, or short chains. L. plantarum is a resilient and highly adaptive bacteria that can grow at temperatures between 12-40 ℃ and at pH level between 3.4-8.8. It uses carbon sources to produce lactic acid, ethanol or acetic acid, and carbon dioxide. It represents a part of the microbiota of many fermented foods. It is also considered as promising next-generation probiotics since it has anti-cancer, anti-inflammatory, antiobesity, and antidiabetic properties.

Lactobacillus plantarum

Potential of L. plantarum Probiotics for Disease Treatment

Lactobacillus probiotics have been reported to have great potential for relieving antibiotic-associated diarrhea. L. plantarum probiotics can reduce the occurrence of loose or watery stools and abdominal pain without negative side effects in a clinical trial of 438 children with antibiotic-associated diarrhea.

L. plantarum has been shown to improve skin hydration, promote the synthesis of collagen, and decrease reactive oxygen species (ROS) production. It may act as an anti-aging agent used for skin health care. Furthermore, L. plantarum has also been shown to relieve the symptoms of atopic dermatitis in humans.

  • Reducing cholesterol

Several clinical trials have reported that L. plantarum probiotics can reduce cholesterol. In a research of 60 individuals with high cholesterol, L. plantarum probiotics decrease total cholesterol by 13.6%. In mice with elevated cholesterol, L. plantarum can significantly reduce total serum cholesterol and triglycerides.

Many studies showed L. plantarum can lower body weight and fat mass in humans and mice. In Russian adults with obesity and hypertension, a probiotic-enriched cheese containing L. plantarum reduced the BMI and blood pressure. Besides, L. plantarum also reduces diet-induced obesity in mice.

L. plantarum has been shown to decrease the level of blood glucose. In mice with a high-fat diet, L. plantarum can significantly reduce blood glucose levels in response to insulin. In the diabetic rats, ingestion of L. plantarum probiotics can also reduce blood glucose and hormones, and increase lipid metabolism.

With the continuous research and understanding of L. plantarum, it is possible to develop L. plantarum probiotics for improving health. To date, we have successfully finished several projects related to next-generation probiotics development and accumulated rich experience. We are confident in offering all-rounded L. plantarum probiotics development services for global customers from program design, implementation to data analysis. We are expected to become your reliable partner in the field of next-generation probiotics development. Please hesitate to contact us to discuss your project.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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