Parabacteroides distasonis as Next Generation Probiotics

Parabacteroides distasonis (P.distasonis) is a member of the gut core microbiome that brings many beneficial properties to its host, in the metabolic, immune, and intestinal inflammation aspects. It could even have the potential to serve as a potential probiotic to promote digestive health in humans based on microbiome or animal studies. Creative Biolabs offers well-established and innovative One-Stop-Shop live biotherapeutic products (LBP) solutions. We are flexible to meet the unique needs of LBP client projects.

Introduction of P. distasonis

P. distasonis is the type of strain for the genus Parabacteroides, a group of gram-negative anaerobic bacteria that commonly colonize the gastrointestinal tract of numerous species. P. distasonis strain has become the strain comparator for all Parabacteroides species. This type of strain is an isolate deposited in 1933 and is a gram-negative, non-spore-forming, rod-shaped, strictly anaerobic bacterium present in the gastrointestinal (GI) tract of humans and animals. A single P. distasonis cell is 0.8-1.6 × 1.2-12 μm in size. Its colonies on sheep blood agar plates are 1-2 mm in diameter, appear gray to off-white, and are circular, slightly convex, and smooth in shape. In intestinal Parabacteroides, P. distasonis is defined as one of the 18 core members of the human intestinal flora and is believed to have important physiological functions in the host. The abundance of P. distasonis is relatively lower in patients with obesity, nonalcoholic fatty liver, and multiple sclerosis.

P. distasonis for Disease Treatment

In a study, oral treatment with live P. distasonis (LPD) reduced weight gain, improved glucose homeostasis, and corrected obesity-related abnormalities, including hyperlipidemia and hepatic steatosis, in both ob/ob mice and high-fat diet (HFD)-induced metabolic syndrome mice. Moreover, the introduction of P. distasonis into obese mice dramatically changed the profile of secondary bile acids. Treatment with P. distasonis also significantly increased intestinal succinate levels, which have recently been identified as an important dicarboxylic acid in maintaining glucose homeostasis. These findings support the gut commensal P. distasonis as a promising probiotic that can modulate host metabolism to alleviate obesity and metabolic dysfunctions.

Probiotic supplementation dampens the systemic inflammatory response to fracture. Fig.1 P. distasonis alleviates obesity and metabolic dysfunctions via the production of succinate and secondary bile acids. (Wang, 2019)


Scientists reported that oral treatment of BALB/c mice with components from the commensal, P. distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies, and stabilized the intestinal microbial ecology. These results suggest that specific bacterial components derived from the commensal bacterium, P. distasonis, may be useful in the development of new therapeutic strategies for chronic inflammatory disorders such as IBD.

What Services Can We Provide for P. distasonis at Creative Biolabs?

P. distasonis Related Products at Creative Biolabs

  • Strain Products

We can supply a variety of P. distasonisstrains of different preservation numbers, the product list is only a few, if you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs is a multidisciplinary, qualified & experienced team, when partnering with us there is no need to change providers, which can be both time-consuming and expensive. We have the expertise to optimize each stage in LBP development to ensure you get your desired outcome, achieving the highest levels of efficiency throughout. If you are interested in our P. distasonisrelated services and products, please contact us for more detail.

Reference

  1. Wang, K.; et al. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell reports. 2019, 26(1): 222-235. e5.

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