Creative Biolabs supports microbiome R&D teams building robust Parabacteroides distasonis programs—from strain sourcing to study-ready materials and decision-grade datasets. This CRO service is designed for biotech, pharma, and academic groups that need reproducible anaerobe workflows, well-controlled characterization, and fit-for-purpose screening to de-risk early research and accelerate confident next steps.
Teams across biotech and academia standardize P. distasonis studies with controlled, comparable workflows.
P. distasonis has become a high-priority commensal in metabolism–immunity–barrier research because its biology intersects bile acid signaling, succinate production, and epithelial integrity. In multiple model systems, strain-dependent effects map to measurable endpoints (bile acid composition, FXR-linked readouts, inflammatory tone, and barrier markers), making it unusually “assayable” for mechanism-focused programs.
The challenge is not interest—it’s execution. As a strictly anaerobic, Gram-negative rod with meaningful strain variability, P. distasonis demands disciplined isolation, identity confirmation, contamination control, and consistent dosing materials. Creative Biolabs structures these steps as an integrated CRO workflow so results stay comparable across batches, assays, and study phases.
Creative Biolabs isolates and screens P. distasonis under strict anaerobic workflows to preserve viability and phenotype. Select isolates using growth kinetics, colony morphology, and functional pre-screens aligned to your endpoints, then lock a reference lot to keep your P. distasonis program comparable over time.
Accurate identification of P. distasonis prevents false positives caused by closely related anaerobes. Creative Biolabs verifies P. distasonis using multi-layer identity confirmation (phenotypic checks plus molecular methods) and documents strain traceability so downstream screening data can be tied back to a defined biological input.
Functional screening is most valuable when P. distasonis readouts connect to a plausible mechanism. Creative Biolabs designs MoA-oriented assay panels (metabolite shifts, bile acid signatures, barrier markers, immune readouts) so P. distasonis candidates can be ranked by potency, consistency, and context-specific activity.
Host interaction testing translates P. distasonis biology into measurable, decision-grade endpoints. Creative Biolabs runs controlled co-culture or conditioned-media formats to quantify epithelial responses, immune crosstalk, and pathway activation, enabling you to compare P. distasonis lots, formats, and dosing strategies under matched conditions.
Immune modulation assays require tight control of bacterial inputs. Creative Biolabs evaluates P. distasonis in standardized in vitro immune formats (cytokine patterns, innate activation markers, immune cell functional outputs) while tracking batch attributes that can confound results, such as viability, medium residues, and handling time.
Scaling P. distasonis is an anaerobe-engineering problem, not just a culture step. Creative Biolabs optimizes fermentation parameters (media composition, redox control, harvest timing) to improve yield and consistency, then transfers conditions into a reproducible manufacturing-style workflow suitable for repeated P. distasonis study lots.
Formulation determines whether P. distasonis performs the same way in week 1 and week 8. Creative Biolabs supports formats such as cryopreserved stocks, lyophilized powders, or defined postbiotic preparations, with stability checks that match your storage, shipping, and dosing constraints for P. distasonis studies.
Research programs still need safety-aware screening. Creative Biolabs offers biological safety testing for P. distasonis materials, including contamination checks and antibiotic susceptibility profiling, helping teams document baseline safety attributes early and prevent costly resets caused by unexpected microbial or functional liabilities.
Define P. distasonis strain goals, endpoints, matrices, controls, and acceptance criteria for each assay.
Obtain P. distasonis isolates, confirm anaerobic handling, and establish traceable seed stocks.
Verify P. distasonis using orthogonal methods; document strain history and reference lot.
Produce P. distasonis in selected format; record process parameters and batch attributes.
Run P. distasonis functional and host interaction tests with standardized QC checkpoints.
Deliver curated P. distasonis datasets with methods, QC, and interpretation-ready summaries.
Tight oxygen control preserves P. distasonis phenotype across culturing and handling.
Identity, purity, and consistency checks keep P. distasonis results interpretable across studies.
Endpoints align P. distasonis signals with measurable pathways, not vague correlations.
Support viable, preserved, or postbiotic P. distasonis materials matched to your assays.
Processes translate from discovery lots to repeatable P. distasonis production runs.
Fewer vendor handoffs reduces variability in P. distasonis programs and timelines.
In models, P. distasonis has been linked to bile acid remodeling and thermogenesis-associated readouts, plus improved insulin-resistance markers via nicotinic-acid–GPR109A signaling—useful for screening metabolic MoA hypotheses and biomarkers.
Literature connects P. distasonis to bile acid–FXR-related pathways and fibrosis-associated phenotypes, and 2025 work reported β-hydroxybutyrate–STAT3 signaling in hepatectomy regeneration models—enabling targeted gut–liver mechanism exploration.
P. distasonis has been studied in barrier-centric models where tight junction and inflammatory markers are quantifiable. This supports assay designs focused on epithelial integrity, cytokine tone, and permeability endpoints under controlled exposure formats.
Recent reports associate P. distasonis administration with increased intratumoral immune infiltration and improved anti-PD-1 response metrics in preclinical cancer models, motivating microbiome-modulator screening alongside immune checkpoint study designs.
A 2025 study reported P. distasonis–linked changes alongside reduced oxidative stress and improved brain-injury–related readouts in high-fat diet models, supporting gut–brain mechanistic exploration with measurable metabolic and neuroinflammation endpoints.
Postbiotic P. distasonis supplementation has been reported to preserve muscle strength and mitochondrial function in aged mice under metabolic challenge, offering a tractable framework for muscle-energy endpoints without relying on viability-dependent dosing.
To support seamless downstream studies, we also provide research-grade materials that help standardize your workflow and strengthen data comparability across experiments.
| Product Name | Catalog No. | Target | Product Overview | Size | Price |
|---|---|---|---|---|---|
| Parabacteroides distasonis; 354946 | LBSX-0522-GF24 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. | 200 µg | $1,000.00 |
| Parabacteroides distasonis; 359508 | LBSX-0522-GF25 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. | 200 µg | $1,000.00 |
| Parabacteroides distasonis; 342474 | LBSX-0522-GF26 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. It was isolated from human faeces. | 200 µg | $1,200.00 |
| Parabacteroides distasonis; quality control | LBSX-0522-GF27 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. | — | Inquiry |
| Parabacteroides distasonis; 5825 | LBGF-0722-GF49 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. | 200 µg | $980.00 |
| Parabacteroides distasonis, 11152 | LBGF-1222-GF4 | Parabacteroides | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. | — | Inquiry |
| Parabacteroides distasonis DNA Standard | LBGF-0224-GF27 | Parabacteroides DNA standard | Parabacteroides distasonis DNA standard product can be used for quantitative research and analysis, assay development, verification, and validation, and laboratory quality control. | — | Inquiry |
Creative Biolabs controls oxygen exposure across culture, harvest, and formulation, then documents time-to-assay and storage conditions. For P. distasonis, this reduces variability that otherwise appears as false “biological” differences.
Yes. P. distasonis can be evaluated as live cells, defined lysates, or supernatants. The service keeps inputs standardized and ties assay outcomes to quantified batch attributes, enabling apples-to-apples interpretation.
At minimum, orthogonal confirmation is advised: a molecular identity method plus phenotypic checks under anaerobic conditions. For P. distasonis, this is paired with traceable seed stocks to prevent drift across passaging.
You receive the P. distasonis material summary, QC results, raw and processed assay data, methods, and a concise interpretation map linking readouts to endpoints—so internal teams can reproduce conditions and justify next actions.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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