Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
Product Information | |
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Product Overview | Parabacteroides distasonis is a Gram-negative, non-sporeforming, obligately anaerobic, rod-shaped, and non-motile bacterium from the genus of Parabacteroides. |
Target | Parabacteroides |
Genus | Parabacteroides |
Strain Designation | NCTC 11152 |
Application | Study and research |
Type Strain | Yes |
Culture Medium | Chocolate agar |
Culture Conditions | 37°C, Anaerobic |
Risk Group | 2 |
Product Format | Freeze-dried |
Packaging | Ampoule tube |
Storage | -80°C |
Shelf Life | 6 years |
Target Introduction | |
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Introduction | Parabacteroides is a Gram-negative, anaerobic, non-spore-forming genus from the family Tannerellaceae. Currently, the genus Parabacteroides includes eight valid species with standing in nomenclature. The species Parabacteroides faecis and Parabacteroides johnsonii; faeces and Parabacteroides gordonii; blood were all isolated for the first time in humans. Of all the species, Parabacteroides distasonis is the reference type strain for the genus Parabacteroides. To date, Parabacteroides distasonis has been shown to have beneficial effects on colorectal cancer. Multiple researchers have identified that levels of Parabacteroides distasonis in stool are inversely correlated to the presence of intestinal tumors. The evidence for the potential anti-inflammatory effects of Parabacteroides distasonis in colorectal cancer is further supported by the inverse correlation between Parabacteroides distasonis levels and IL-1β production in the gut, suggesting that Parabacteroides distasonis has anti-tumorigenic and anti-inflammatory potential in colorectal cancer patients. Further potential benefits of Parabacteroides distasonis have been identified, particularly in relation to obesity. In addition, several studies have suggested that Parabacteroides distasonis may play a role in various forms of autoimmunity. |
Alternative Names | Parabacteroides distasonis, 11152 |
Parabacteroides distasonis thrives in anaerobic conditions, ideally within a temperature range of 35-37°C. It requires a nutrient-rich medium to support its growth. Proper anaerobic chambers or environments are essential to maintain its viability during experiments.
This strain is predominantly used to study the gut microbiota's role in health and disease, including its interactions with the host immune system, its metabolic functions, and its potential in modulating inflammatory responses. Researchers also use it to explore its effects on diseases such as inflammatory bowel disease and obesity.
While handling Parabacteroides distasonis, it is crucial to follow standard laboratory safety protocols for anaerobic bacteria. This includes using appropriate containment to prevent exposure, as it is strictly for research use and not for human consumption or clinical applications.
Quantification of Parabacteroides distasonis is typically performed using quantitative PCR (qPCR), 16S rRNA sequencing, or flow cytometry. These methods allow for accurate measurement of bacterial abundance in various samples, such as gut microbiota studies.
Yes, Parabacteroides distasonis can be used alongside other probiotic strains to study synergistic effects and their combined impact on gut health. Co-culturing with other beneficial microbes can help understand their interactions and collective benefits on the host.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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