Oxalobacter formigenes as Next Generation Probiotics

The bacterium Oxalobacter formigenes (O. formigenes) is currently being developed as a potential treatment for primary hyperoxaluria in patients at different stages of renal function. As a leader in live biotherapeutic products (LBPs) research, Creative Biolabs can provide flexible solutions for your LBP development projects. You can start our cooperation and rely on us.

Introduction of O. formigenes

One of the most efficient oxalate-degrading organisms is O. formigenes, a Gram-negative, non-pathogenic, anaerobic commensal bacterium, naturally occurring in the colon of humans and other vertebrates and exclusively relying on oxalate to formate conversion as its energy source. The presence of oxalate-powered bacteria, isolated from the faeces of patients without kidney stones, has been associated with reduced oxalate excretion in the urine. It increases the active transcellular secretion of oxalate from the blood to the gastrointestinal tract through interaction with transporter proteins, possibly from the SLC26 family.

(A) Electron micrographs of <em>O. formigenes</em> strain OxWR1, (B) Gram stain of <em>O. formigenes</em> strain HOxBLS. Fig.1 (A) Electron micrographs of O. formigenes strain OxWR1, (B) Gram stain of O. formigenes strain HOxBLS. (Daniel, 2021)

O. formigenes for Primary Hyperoxaluria (PH) Disease

The effect of O. formigenes on nephrocalcinosis was studied in ethylene glycol rat models simulating hepatic oxalate overproduction in PH. Plasma and urine oxalic acid levels, calcium oxalate crystalluria, urinary volume, fluid intake, and serum creatinine were monitored during the study. Ethylene glycol intake induced pronounced hyperoxaluria, hyperoxaluria, calcium oxalate crystalluria, and nephrocalcinosis. Concomitant O. formigenes treatment partially prevented the ethylene glycol-induced increase in plasma oxalate and completely prevented nephrocalcinosis. These results showed a beneficial effect of O. formigenes treatment on ethylene glycol-induced hyperoxaluria and nephrocalcinosis, and thus support a possible beneficial effect of O. formigenes in PH.

Overview of the possible gut-kidney axis in nephrolithiasis, with <em>O. formigenes</em> at the center of a bacterial network involved in oxalate degradation and protecting against the onset of hyperoxaluria. Fig.2 Overview of the possible gut-kidney axis in nephrolithiasis, with O. formigenes at the center of a bacterial network involved in oxalate degradation and protecting against the onset of hyperoxaluria. (Ticinesi, 2019)

What Services Can We Provide for O. formigenesat Creative Biolabs?

O. formigenes Related Products at Creative Biolabs

  • Strain Products

We supply a variety of O. formigenes strains of different preservation numbers as below. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Treatment with O. formigenes represents a novel therapeutic approach to potentially prevent further CaOx deposition. At Creative Biolabs, we have the expertise to optimize each stage to ensure you get your desired outcome. Please feel free to contact us for further discussion of O. formigenes projects.

References

  1. Daniel, S.L.; et al. Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist. Applied and Environmental Microbiology. 2021, 87(18): e00544-21.
  2. Ticinesi, A.; et al. Gut microbiome and kidney stone disease: Not just an Oxalobacter story. Kidney International. 2019, 96(1): 25-27.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

Live Biotherapeutics Drug Discovery

Online Inquiry

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

Contact us

Contact us

Copyright © 2022 Creative Biolabs. All Rights Reserved.

Inquiry Basket