Live Biotherapeutics Drug Discovery Service for Aging
Overview
Human aging is a stochastic, detrimental, and progressive phenomenon that leads to increasing morbidity and mortality in the elderly. This is an inevitable biological process that is often accompanied by biological and physiological changes with altered cellular function. Aging is related to degenerative changes in multiple organs, including the central nervous system. In the elderly population, their gut microbiota has several distinctive characteristics: low phyla bacterial diversity, changes in dominant species that colonize the gut, increased anaerobic bacteria to favorable commensal bacteria ratio, and reduction in microbial metabolic activities. More and more people are realizing the benefits of using probiotics for elderly people to maintain health and improve their quality of life. Various studies have emphasized the importance of probiotics and probiotic-containing fermented plant products in the aging process. One of these bacteria is Lactobacillus, a popular probiotic strain with recognized health benefits. Most probiotics, especially those with immunomodulatory, anti-inflammatory, and anti-infection functions, are beneficial to improving the quality of life of the elderly. For the most part, they can all be generalized into geriatric biology.
Fig.1 Nine hallmarks of aging.1
Anti-Aging Property of Probiotics
Probiotics elicit several anti-aging properties, which include increasing the mechanisms of antioxidant, serotonin, and p38MAPK signaling pathway; activation of plasmacytoid dendritic cells; preventing hair loss, skin ulcers, thinning and wrinkling of the skin; improving skin elasticity, gloss, and moisture content; and increasing bone density.
Secretory Metabolites of Probiotics That Influence Aging
The secretion factors of probiotics are diverse, typically including short-chain fatty acids (SCFAs), peptides, lactic acid, vitamins, polyamines, and polyphosphates. These molecules, especially SCFAs and polyamines, have a causal relationship with aging and health. SCFAs are produced by fermentation by intestinal bacteria, and the supplementation of these molecules has shown evidence of improving inflammation, neurological health, and aging.
Fig.2 Probiotics can influence the process of senescence.2
Models for Anti-Aging Probiotics Research
Many probiotics with anti-aging potential have been identified, mainly by invertebrate models to study life span extension and by rodent models to study detailed molecular mechanisms. Clinical trials of certain probiotic strains have even been completed with encouraging results in anti-aging.
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Invertebrate Model Organisms
Caenorhabditis elegans is a powerful in vivo model for studying host-probiotic interactions. Almost all lactic acid bacteria with longevity potential have been reported to have antioxidant effects. D. melanogaster was rarely used in the past to study the anti-aging effects of probiotics, but this has changed because axenic Drosophila can be easily generated, and studying single associations of individual probiotic strains has made it easier to perform aging-related studies.
Rodent models of aging are commonly used to study the anti-aging effects of probiotics. Animal models of accelerated aging induced by D-galactose are also widely used to evaluate the anti-aging effects of probiotics.
Fig.3 The strategy for the identification of potential gerobiotics.1
Our Services for Ageing Research
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Research Articles
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Available Services
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Probiotics and prebiotics as a therapeutic strategy to improve memory in a model of middle-aged rats.3
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A potential probiotic Lactobacillus plantarum improves longevity and healthy aging by modulating antioxidative, innate immunity, and serotonin-signaling pathways.4
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Creative Biolabs has accumulated extensive project experience in the analysis of probiotic properties and the production of laboratory-scale probiotics. We have technical experts with excellent microbiology backgrounds to provide you with reasonable advice, please do not hesitate to contact us for more details.
References
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Tsai, Ying-Chieh, et al. "Gerobiotics: probiotics targeting fundamental aging processes." Bioscience of microbiota, food and health 40.1 (2021): 1-11.
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Sharma, Rohit, and Yogendra Padwad. "Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities." Gut microbes 11.3 (2020): 335-349.
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Romo-Araiza, Alejandra, et al. "Probiotics and prebiotics as a therapeutic strategy to improve memory in a model of middle-aged rats." Frontiers in aging neuroscience (2018): 416.
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Kumar, Arun, et al. "A potential probiotic Lactobacillus plantarum JBC5 improves longevity and healthy aging by modulating antioxidative, innate immunity and serotonin-signaling pathways in Caenorhabditis elegans." Antioxidants 11.2 (2022): 268.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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