Gut Microbiota Research Technologies
Background Services Advantages Resources
Understanding the factors that influence changes in the composition and function of the gut microbiota will help in the design of treatments for it. Creative Biolabs specializes in live biotherapeutic products (LBP) development. Devoted to providing professional and well-tailored custom services for more than 10 years, we have accumulated profound experience in the study of gut microbiota.
Background
The human digestive tract is home to many microorganisms, including diverse populations of bacteria. The total number of species found in the gut microbiota is about 500 to 1000. The majority of bacteria in the adult gut are non-sporing anaerobic bacteria, with the largest number including Bifidobacterium spp., Bacteroides spp., Clostridium spp., Eubacterium spp., Lactobacillus spp., Fusobacterium spp., and various gram-positive cocci. Bacteria that are present in lower numbers include Enterobacteriaceae, Enterococcus spp., methanogens, and dissimilatory sulfate-reducing bacteria. The microbiome provides many benefits to the host through a range of physiological functions, such as strengthening intestinal integrity or shaping intestinal epithelium, gathering energy, defending against pathogens, and regulating host immunity.
Technologies to Study the Gut Microbiota at Creative Biolabs
The application of molecular tools to intestinal microbiology has greatly facilitated the study of the complex microbial community resident in the human intestinal tract, and the classical microbiological techniques are not obsolete but complementary to the molecular techniques being developed.
Methods
Samples Types
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Human feces or intestinal contents.
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Animal feces or intestinal contents: Mouse, rat, guinea pig, monkey, cat, dog, chicken, sheep, fish, rabbit, worm, horse, pig, etc.
Fecal sample collection can refer to the introduction here. If you have any other questions, please contact us directly.
Sample Requirements
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Fecal sample or intestinal contents sample: 1-3g per sample, fresh sampling, store at -80℃, avoid repeated freeze-thaw, dry ice transport.
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Genomic sample: Total genomic DNA ≥300ng, ≥10ng/μL, OD260/280=1.8-2.0, and ensure that DNA is not degraded, avoid repeated freeze-thaw, dry ice transport.
Target Organisms
Bacteria, fungi, actinomyces, etc.
Deliverables
Upon completion of the development services, a final report will be issued.
Potential Industries & Applications
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Medical field: Study on the relationship between disease and human microbiome.
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Animal field: intestinal and animal health, nutrition and digestion research.
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Academic research.
Factors Shaping the Gut Microbiota
The composition of the microbiota is influenced by host and environmental selection pressures. Studies have shown that diet has a big impact on gut microbiota. Cooperation among gut microbes also allows for a greater diversity of microbes to colonize and form the gut microbiota community. The distribution of bile acids in the small and large intestines also affects the dynamics of the intestinal bacterial community. The microbiota can also be shaped by the host immune system. Several environmental factors affecting microbiota formation include geographical location, surgery, smoking, depression, and living arrangements. Antibiotic treatment significantly disrupts the short - and long-term microbial balance, including a reduction in community richness and diversity.
Advantages
Research on the gut microbiota offers several advantages for understanding human health:
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Diverse Functions: Gut microbiota plays a vital role in the immune system, digestion, and metabolism.
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Health Maintenance: A healthy gut microbiome contributes to effective digestion, absorption, and absence of gastrointestinal illnesses.
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Drug Discovery: Collecting microbiome data enables a "deep phenotyping" approach that could transform drug discovery.
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Disease Insights: Studying gut microbiota can help us develop potential treatments for diseases.
In summary, the gut microbiota is a fascinating area of research with wide-ranging implications for human well-being.
Resources
Creative Biolabs is a premier provider of customized solutions for LBP development. We are "LBP Problem-Solvers" focused on delivering best-in-class custom services. If you are interested in our technology for gut microbiota research, please contact us for more. We welcome the opportunity to discuss the ways we can work with you to accomplish your unique goals.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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