Accelerate Nutritional Supplement Development: Probiotic Solution & CRO Service

Are you a supplement manufacturer, ingredient supplier, or pioneering formulator aiming to develop cutting-edge probiotic-based nutritional supplements? Do you require expert guidance in strain selection, formulation optimization, stability testing, and robust scientific validation? Your search ends here. At Creative Biolabs, we offer a comprehensive suite of Probiotic Solutions and tailored Contract Research Organization (CRO) services meticulously designed to accelerate your nutritional supplement development from concept to market leadership. Request a quote

The Indispensable Role of Probiotics in Nutritional Supplements

Fig.1 Probiotic for Nutritional Supplement. (Creative Biolabs Authorized)

Probiotics have gained increasing popularity because they can enhance the efficacy and appeal of nutritional supplements. Their inclusion can transform standard supplements into targeted wellness solutions. The nutritional supplement market is dynamic, with a growing consumer focus on proactive health and wellness. Probiotics have emerged as a cornerstone ingredient, recognized for their profound impact on gut health and overall well-being, making them a vital component of innovative and effective nutritional supplements.

Probiotic Solutions & CRO Services: Your Supplement Innovation Advantage

Strain Services
Formulation Services
Analytical Services

Probiotic Strain Selection and Characterization

  • Rigorous screening of a wide array of probiotic strains based on their documented health benefits, compatibility with other supplement ingredients, and stability under various storage conditions.
  • Comprehensive in vitro characterization, including acid and bile tolerance, adhesion to intestinal cells, antimicrobial activity, and genetic profiling.
  • Access to well-characterized probiotic strains with extensive safety and efficacy data.
  • Expert guidance on selecting synergistic probiotic combinations for enhanced product benefits.

Preclinical Studies

  • We design and conduct preclinical studies, including in vitro and in vivo assays, to evaluate the safety and efficacy of the probiotic strains or formulations. This may involve assessing the impact of probiotics on gut microbiota composition, immune function, or specific disease models.

Fermentation Process Development

  • We develop and optimize fermentation processes to maximize the yield and viability of the probiotic biomass. This involves carefully controlling parameters such as media composition, temperature, pH, and oxygen levels in bioreactors. We offer a range of fermentation scales, from small-scale to pilot-scale, to support different project needs.

Formulation Development and Optimization

  • Design of stable and effective supplement formulations incorporating probiotics alongside vitamins, minerals, botanicals, and other active ingredients.
  • Evaluation of the impact of manufacturing processes (e.g., compression, encapsulation) on probiotic viability.
  • Development of strategies to ensure optimal probiotic survival and delivery, considering factors like moisture content, pH, and excipients.
  • Formulation of delayed-release capsules or enteric coatings to protect probiotics from stomach acid.

Stability Testing and Shelf-Life Determination

  • Comprehensive stability studies under various temperature and humidity conditions to determine the shelf life and ensure the potency of your probiotic supplement.
  • Real-time and accelerated stability testing according to ICH guidelines.
  • Development of appropriate packaging solutions to maintain probiotic viability.

Analytical Testing and Quality Control

We perform a suite of analytical tests to ensure the quality and consistency of the final probiotic product. This includes:

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Our Range of Probiotic Products for Preclinical Research

Contact us to explore our specific probiotic strains, customized blending options, and advanced delivery technologies for your nutritional supplement development.

Mechanism of Action: How Probiotics Enhance Nutritional Supplements

Gut Microbiota Modulation

Probiotics can colonize the gut, contributing to a more balanced and diverse microbial ecosystem associated with improved digestive health, nutrient absorption, and immune function.

Production of Beneficial Metabolites

In the gut, probiotics produce short-chain fatty acids (SCFAs), vitamins (e.g., vitamin K, B vitamins), and other bioactive compounds that exert systemic health benefits.

Enhanced Nutrient Utilization

Some probiotics can produce enzymes that aid in the breakdown of complex carbohydrates and other dietary components, potentially improving the bioavailability of nutrients from the diet and the supplement itself.

Support of the Gut-Immune Axis

Probiotics can interact with the gut-associated lymphoid tissue (GALT), regulate immune responses, and contribute to the overall health of the immune system.

Mitigation of Supplement Side Effects

In some cases, probiotics may help mitigate potential gastrointestinal side effects associated with certain supplements.

Why Choose Us for Your Probiotic Supplement Innovation?

  • Integrated Solutions
  • Expertise
  • Advanced Technology
  • Customization
  • Quality and Reliability
  • Accelerated Timelines

Who We Serve: Our Target Customer Groups

  • Nutritional Supplement Manufacturers
  • Ingredient Suppliers
  • Contract Manufacturing Organizations
  • Healthcare Practitioners and Formulators

At Creative Biolabs, we are committed to providing our clients with the highest quality services and support. We are confident that our Probiotic Solution & CRO Service can help you accelerate your research, streamline your development process, and bring successful probiotic products to market. Contact our team for more information and to discuss your project.

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FAQs

Why is stability testing crucial for probiotic supplements?

Stability testing ensures that the probiotic potency on the label remains consistent throughout the product's shelf life, guaranteeing that consumers receive the intended dose of live microorganisms.

What are the advantages of using spore-forming probiotics in supplements?

Probiotics that form spores possess extremely high stability and resistance to harsh environments, which makes them highly suitable for various supplement forms and ensures their high activity even after consumption.

What are the key factors to consider when developing a probiotic supplement?

Key factors include strain viability and stability, resistance to gastric acid and bile salts, adhesion to intestinal cells, and documented health benefits. Our services address all these critical factors to ensure the success of your product. Reach out to us for a detailed consultation.
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