Ruminococcus spp. as Next Generation Probiotics

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Introduction of Ruminococcus spp.

Ruminococcus is an important group of intestinal mutualistic bacteria, which degrade complex polysaccharides and convert them into various nutrients of the host. Ruminococcus is a bacterium in the class Clostridia. The genus Ruminococcus is defined as strictly-anaerobic, Gram-positive, non-motile cocci that do not produce endospores and require fermentable carbohydrates for growth. One or more species in this genus are found in significant numbers in the human gut microbiota. Most species of Ruminococcus are important and necessary for our digestive function. Next-generation sequencing has further shown that they are widely distributed in multiple animal hosts. The ruminococcus is now recognized as an important contributor to the intestinal ecosystem. Members of the genus Ruminococcus also have great application potential in biotechnology.

The best studied of the Lachnospiraceae is Ruminococcus gnavus. This species is also a member of the core gut microbiota. The Ruminococcus gnavus administration may modulate the Th2-related allergic inflammation in atopic dermatitis (AD) by inducing changes in SCFA-related and Treg-mediated immune pathways in the gut.

Hydrogen-producing Ruminococcus albus is more abundant in healthy individuals than in patients with Crohn’s disease and shows probiotic effects. Heat-killed Ruminococcus albus can inhibit oxidative stress-mediated neuronal cell damage and produce the neuroprotective effect.

Health Benefits of Ruminococcusspp.

The dominant commensal symbiont bacteria that produce SCFAs are Akkermansia muciniphilia, Prevotella spp., Ruminococcus spp., Coprococcus spp., Faecalibacterium prausnitzii, Eubacterium rectale, and Roseburia. The Ruminococcus bacteria in our gut microbiomes play a major role in helping us digest resistant starches. The slow digestion of these particular carbohydrates by Ruminococcus has been linked to many health benefits such as reversing infectious diarrhea and reducing the risk of diabetes and colon cancer. Members of Clostridium clusters XIVa and IV (e.g., Dorea spp., Lachnospiraceae, Ruminococcus spp., Faecalibacterium spp., and Roseburia spp.) are consistently depleted in people with IBD and acute colitis, suggesting that these organisms are important in maintaining intestinal homeostasis. Most normal-weight children have a gut bacterial community dominated by Ruminococcus spp., while most obese children had a community dominated by Prevotella spp.

Metabolism of resistant starch, a prebiotic, to butyrate and its known effects on the colon. Fig.1 Metabolism of resistant starch, a prebiotic, to butyrate and its known effects on the colon. (Chang, 2021)

Services and products about Ruminococcusspp. at Creative Biolabs

  • Services

We provide Microbial Isolation and Screening, Microbial Identification, Microbial Purifying, and other analytical development services for Ruminococcus spp.

  • Products

The strains with different preservation numbers in Ruminococcus spp. can be supplied. In addition, we can customize the production of strain culture supernatant and lyophilized powder containing certain CFU according to the customer's research.

Key Features of Creative Biolabs’ Services

  • Cost effective and comprehensive
  • Fast turnaround time
  • Guaranteed results

The development and validation of probiotics and LBP are complex and require carefully designed studies. Creative Biolabs has the expertise to optimize each stage. Contact us to learn more about our LBP development service.

Reference

  1. Chang, A.E.; et al. Targeting the gut microbiome to mitigate immunotherapy-induced colitis in cancer. Trends in Cancer. 2021, 7(7): 583-593.

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