Bifidobacterium dentium as Next Generation Probiotics

Creative Biolabs provides professional live biotherapeutic products (LBP) customer service, from the candidate strain screening, identification, characterization, safety evaluation, and functional validation to product analysis, which are performed by research scientists with long experience in this field.

Introduction of Bifidobacterium dentium (B. dentium)

B. dentium is a species of bacteria in the genus Bifidobacterium, branched anaerobic bacteria from the Bifidobacteriaceae family. B. dentium is an acetate producing colonizer in the gastrointestinal tract of healthy adults. It can be found as part of the microbiota implicated in human dental caries. B. dentium was the most commonly isolated Bifidobacterium, accounting for about 8% of culturable bacteria isolated from active caries. This species is acid-producing and can produce a final pH below 4.2 in glucose-containing media, sufficient to cause extensive demineralization of tooth tissues. Therefore, B. dentium may play an important role in the pathogenesis of caries.

B. dentium for Disease Treatment

The intestinal barrier is crucial for preventing IBD. Using a lipopolysaccharide (LPS) -induced Caco-2 cell model, scientists investigated the underlying mechanism of B. dentium N8's protective effect on the intestinal barrier. The results showed that B. dentium N8 had a higher adhesion ability and a more substantial inhibition effect on Escherichia coli adhesion to HT-29 cells. B. dentium N8 significantly decreased the paracellular permeability of Caco-2 cells. In addition, B. dentium N8 significantly increased the mRNA expression of ZO-1, occludin, and claudin-1. It also had the specific genes encoding for adhesion ability and immune system regulation. This study provides a theoretical basis for the protective effect of B. dentium N8 on the intestinal barrier, indicating that B. dentium N8 could be used as a new drug for IBD treatment.

  • Neurologic Disorders

There is growing evidence that gut microbes can synthesize neurotransmitters and influence host-derived neurotransmitter levels. To determine whether B. dentium affects neurotransmitters in vivo, a single correlation test was performed on sterile mice using B. dentium, and fecal and brain neurotransmitter concentrations were measured. The results showed that B. dentium possessed the enzymatic machinery to generate -aminobutyric acid (GABA) from glutamate, glutamine, and succinate. In vivo, the scientists found elevated levels of tyrosine in the faeces and brains of mice that were single associated with the B. dentium. These data suggest that B. dentium can be involved in neurotransmitter regulation in vivo. A better understanding of the gut-brain axis pathways may provide novel adjuvant strategies for both gastroenterological and neurologic disorders.

Model diagram of <em>B. dentium</em> colonization. Fig.1 Model diagram of B. dentium colonization. (Luck, 2021)

What Services Can We Provide for B. dentium at Creative Biolabs?

B. dentium Related Products at Creative Biolabs

  • Strain Products

We supply a variety of B. dentium strains of different preservation numbers as below. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs is an established, global LBP development service provider located in the United States. We aim to combine your expertise with our expertise so that together we succeed, our team is ready to help. If you are interested in our B. dentium related products and services, please feel free to contact us for more.


  1. Luck, B.; et al. Neurotransmitter Profiles Are Altered in the Gut and Brain of Mice Mono-Associated with Bifidobacterium Dentium. Biomolecules. 2021, 11(8): 1091.

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