Ruminococcus albus as Next Generation Probiotics

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Introduction of Ruminococcus albus (R. albus)

Bacteria belonging to R. albus contain cellulosomes that allow them to adhere to and digest cellulose, and their genomes encode cellulase and hemicellulase. R. albus is a primary cellulose degrader that produces acetate usable by its bovine host. R. albus, an anaerobic ruminal bacterium, produces acetate, ethanol, formate, hydrogen, and carbon dioxide from carbohydrates. Hydrogen-producing R. albus is more abundant in healthy individuals than in patients with Crohn’s disease and shows probiotic effects. No R. albus was found in the faeces of children with autism, while high levels of R. albus were found in the faeces of control children.

Neuroprotective Effect of R. albus

Gut microbiota plays an important role in gut-brain communication and has been linked to neuronal disorders. The researchers investigated the neuroprotective effects of R. albus with probiotic potential on oxidative stress SH-SY5Y neuroblastoma cells and animals. Treatment with heat-killed R. albus reduced the level of ROS, and the levels of SOD and GSH increased in oxidatively stressed brains. Heat-killed R. albus can inhibit oxidative stress-mediated neuronal cell damage and produce the neuroprotective effect. Therefore, R. albus could be a source of potential therapeutic approaches to alleviate oxidative stress-induced brain damage.

Histological analysis of brain, liver, and kidneys of rats oxidatively stressed with sodium arsenate (As). Fig.1 Histological analysis of brain, liver, and kidneys of rats oxidatively stressed with sodium arsenate (As). (Park, 2017)

What Services Can We Provide for R. albusat Creative Biolabs?

R. albusRelated Products at Creative Biolabs

  • Strain Products

We supply a variety ofR. albus strains of different preservation numbers. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs’ experienced R&D team provides you with all the support you need during LBP development for your projects that are in the pipeline. We have expertise and capabilities in providing high-quality solutions. We are happy to discuss your objectives. Please feel free to contact us for more.

Reference

  1. Park, J.; et al. Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals. Scientific reports. 2017, 7(1): 1-13.

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