Eubacterium hallii as Next Generation Probiotics
Background E. hallii and Diseases Services Products FAQs Resources
Introduction of E. hallii
Eubacterium hallii ( E. hallii) has been identified as a candidate for next generation probiotics (NGPs) with exciting potential for the prevention and treatment of such dysbiosis-associated diseases. Creative Biolabs offers well-established and innovative One-Stop-Shop live biotherapeutic products (LBP) solutions. We are flexible to meet the unique needs of LBP client projects.
Introduction of E. hallii
E. hallii is an anaerobic, Gram-positive, catalase-negative bacterium belonging to the Lachnospiraceae family of the phylum Firmicutes that is present in both murine and human faeces. These bacteria are represented by a rigid cell wall. They are non-motile. E. hallii is a butyrate-producing species. Interestingly, unlike other intestinal isolates such as Roseburia and Faecalibacterium that produce butyric acid from monosaccharides, E. hallii also can produce butyrate from lactate and acetate in low pH environments, such as the proximal small intestine. It is considered as the common gut microbe that contributes to intestinal propionate formation. E. hallii has been widely used in the pharmaceutical, food and feed industries. For example, it has been used to treat complications associated with insulin resistance, such as dyslipidemia, Cushing’s syndrome, type 1 diabetes mellitus, endocrine diseases, etc.
Fig.1 Graphical summary of E. hallii interactions in gut epithelium responsible for maintaining host health. 1
E. hallii and Disease
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Diseases
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Functions of E. hallii
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Metabolic Disease
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An altered intestinal microbiota composition is associated with insulin resistance and type 2 diabetes mellitus. Scientists previously identified increased intestinal levels of Eubacterium hallii in metabolic syndrome subjects who received a faecal transplant from a lean donor. To further assess the effects of E. hallii on insulin sensitivity, we orally treated obese and diabetic db/db mice with alive E. hallii and glycerol or heat inactive E. hallii as control. Experimental results showed that oral active E. hallii improved insulin sensitivity and significantly increased energy expenditure in db/db mice with severe insulin resistance. It was found that treatment with active E. hallii increased fecal butyric acid concentration and changed bile acid metabolism. These findings suggested that E. hallii administration potentially altered the function of the intestinal microbiome and that microbial metabolites may contribute to the improved metabolic phenotype, which potentially contributes to the beneficial effects of E. hallii treatment on insulin sensitivity in obese and diabetic db/db mice.
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Fig.2 E. hallii treatment improves insulin sensitivity and energy expenditure.2
What Services Can We Provide for E. hallii at Creative Biolabs?
E. hallii Related Products at Creative Biolabs
We supply a variety of E. hallii strains of different preservation numbers as below. If you need other strains, please contact us.
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Customized strain culture supernatant. (e.g.: for animal research)
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Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)
E. hallii is a promising candidate as keystones species so far identified that hopefully will have a great impact on the fight against metabolic and inflammatory dysbiosis-derived diseases. Creative Biolabs can apply our considerable experience with LBP development to develop the necessary analytics specific to your project. If you are interested in our E. hallii related services or products, please feel free to contact us for more.
FAQs
How does E. hallii impact metabolic health?
Research has shown that E. hallii has potential therapeutic effects on metabolic disorders, such as improving insulin sensitivity in experimental models. This is believed to be due to its influence on bile acid metabolism and the production of SCFAs, particularly butyrate, which are crucial for energy metabolism and anti-inflammatory effects.
What unique metabolic pathways does E. hallii utilize?
E. hallii is unique among gut commensals for its ability to utilize lactate in the presence of acetate to produce butyrate. This metabolic flexibility highlights its potential role in converting potentially harmful substrates in the gut into beneficial SCFAs, thereby supporting overall gut health.
What are the safety and clinical implications of using E. hallii?
As a next-generation probiotic, E. hallii comes from well-characterized, safe sources and has shown promise in preclinical trials for treating and preventing inflammatory and metabolic disorders. Its development includes stringent safety assessments to ensure it is beneficial without adverse effects.
What are the future research directions for E. hallii in probiotics development?
Future research on E. hallii could explore its interactions with other gut microbiota members and its long-term effects on human health. Additionally, studies could investigate the optimal conditions for its growth and activity in the gut, aiming to enhance its efficacy and stability as a probiotic supplement.
Resources
References
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Almeida, D.; et al. Evolving trends in next-generation probiotics: a 5W1H perspective. Critical reviews in food science and nutrition. 2020, 60(11): 1783-1796.
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Udayappan, S.; et al. Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice. NPJ biofilms and microbiomes. 2016, 2(1): 1-10.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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