Pediococcus pentosaceus as Next Generation Probiotics

Creative Biolabs has established a cutting-edging platform by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial expertise in the development of Pediococcus pentosaceus as next-generation probiotics (NGPs). Our experienced scientists are glad to apply this special expertise to help our worldwide customers with their meaningful research projects.

Introduction of P. pentosaceus

Belonging to Gram-positive, anaerobic Firmicutes, P. pentosaceus is coccus-like microbe, non-motile, non-spore forming. P. pentosaceus are categorized as a "lactic acid bacteria" because the end product of its metabolism is lactic acid. P. pentosaceus can be cultured at 35 ℃-40 ℃ but are unable to grow at 50 ℃. P. pentosaceus can grow in pH 4.5-8.0 and is more stably at the more acidic pH range. Pediococcus are unique in that they form tetrads, which are formed via cell division in two perpendicular directions in a single plane. They can be found in plant materials, ripened cheese, and a variety of processed meats. P. pentosaceus is industrially important due to its ability as a starter culture to ferment foods.

Applications of P. pentosaceus in the Field of Biotechnology

Pediococcus pentosaceus

P. pentosaceus is being studied for its ability to produce an antimicrobial agent as well as its use in food preservation. P. pentosaceus can produce an antimicrobial agent known as bacteriocins against several species of Lactobacillus, lactococcus, leuconostoc, pediococcus, staphylococcus, enterococcus, bacillus and listeria. Antimicrobial agents are produced by bacteria to limit the growth of competitors and/or other harmful bacteria. One P. pentosaceus strain, LAB6 exhibited a cholesterol-lowering effect in various degrees, 19-59% in the absence and 14-9% in the presence of bile salts. Moreover, previous reports have shown that P. pentosaceus is also involved in catheter-associated with infection and endocartitis. Further clinical trials are necessary to conclusively prove the benefits of P. pentosaceu.

Develoment of P. pentosaceu as NGPs at Creative Biolabs

Most of the current research is associated with the applications of P. pentosaceus in the field of biotechnology. Continuing research is still being done to refine P. pentosaceus as a starter culture for fermentation. Valuable lessons have been learned from working with traditional probiotics, Creative Biolabs is committed to exploring the kinds of organisms likely to be used as novel microbial therapeutics and P. pentosaceu is a good candidate. Our multidisciplinary teams work together closely to address these scientific and technical challenges.


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Our comprehensive powerful platform, professional technical scientists and abundant experience make Creative Biolabs a perfect partner to help our clients in the development of Pedioccus pentosaceus as NGPs. Just feel free to contact us and communicate with us about your specific puzzles. Our PhD scientists will offer you professional solutions as soon as possible.


  1. Bajpai, V.K.; et al. Characterization and antibacterial potential of lactic acid bacterium Pediococcus pentosaceus 4I1 isolated from freshwater fish Zacco koreanus. Frontiers in microbiology. 2016, 7: 2037.

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