Faecal Microbiota Transplants (FMT)
The team at Creative Biolabs has extensive experience in the technical field of live biotherapeutics. We have the knowledge and expertise to provide high-quality products and services and provide a high level of consultation to our clients on their next-generation probiotics development projects. Our clients include the world's leading pharmaceutical and biotechnology companies, as well as academic researchers.
How is Faecal Microbiota Transplants (FMT) Defined?
FMT has been described as the transfer of biological material containing a minimally manipulated community of microorganisms from a human donor to a human recipient (including autologous use) with the intent of affecting the microbiota of the recipient. Fecal microbiota can be isolated from the feces of carefully selected donors, quantified according to the number of viable bacteria, stored frozen, and banked. The graft material can be delivered in a variety of ways, including as an encapsulation form for oral drugs. FMT is generally considered safe with most short-term risks attributable to the method of administration rather than FMT itself.
Fig.1 Experimental methods of gut microbiota. (Lu, 2018)
Mechanisms of FMT
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Competition with Indigenous Gut Microbiota
Competitive niche exclusion is a plausible mechanism for the FMT treatment of CDI and a fundamental hypothesis for the development of nonvirulent Clostridium difficile strains as therapeutic agents. Producing bacteriocins, which are antimicrobial peptides with bactericidal or bacteriostatic activities, is a more aggressive strategy against competitors.
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The Role of Secondary Bile Acid Metabolism
FMT rapidly restored secondary bile acid metabolism, and the total composition of fecal bile acids was similar to that of the donor.
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Bile-acid-based Approaches
Bile acid analogs can be developed with enhanced inhibitory activity and good pharmacokinetic properties to ensure adequate and prolonged concentrations in the colon.
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Immune-mediated Colonization Resistance
Routes of Administration of FMT
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Colonoscopy
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Esophagogastroduodenoscopy
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Percutaneous Endoscopic Cecostomy
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Transendoscopic Enteral Tube
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Retention Enema
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Nasoduodenal Route
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Nasojejunal Route
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Oral Capsules
Fig.2 Routes of administration of FMT. (Gulati, 2020)
Applications of FMT
FMT is an effective treatment for patients with rCDI and potentially a wide range of other diseases. It is now an accepted treatment in many countries and there are many clinical studies investigating its utility in many disease areas. FMT can be applied to many conditions, including many problems related to the digestive tract, such as IBS and IBS. FMT might also be beneficial as a treatment for development problems with metabolism, autoimmunity, and the nervous system. The next major application of FMT is likely to continue to be associated with complications of antibiotic therapy and the emergence of increasingly virulent, multidrug-resistant pathogens.
FMT Services at Creative Biolabs
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Gut Microbiota Extraction
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In Vivo Transplantation
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Phenotype Identification
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Sequencing Analysis
* FMT services are intended for preclinical research use only.
As a leading international biotechnology company, Creative Biolabs’ team of highly qualified and experienced technicians will work with you to develop and provide testing and analysis solutions. We have the expertise to optimize each stage to ensure you get the results you want. If you are interested in our FMT service for research use, please do not hesitate to contact us.
References
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Lu, C.C.; et al. Intestinal dysbiosis activates renal renin-angiotensin system contributing to incipient diabetic nephropathy. International journal of medical sciences. 2018, 15(8): 816
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Gulati, M.; et al. Delivery routes for faecal microbiota transplants: available, anticipated and aspired. Pharmacological Research. 2020, 159: 104954.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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