Prevotella copri as Next Generation Probiotics
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Introduction of P. copri
Creative Biolabs has expanded our strain collection for next-generation probiotics (NGPs) from the human microbiome. We guarantee that our global clients will get high-quality and high-safety Prevotella copri (P. copri) for production and formulation into commercial products. We are more than happy to share our extensive experience and help our customers with this extremely important step in the development of NGP.
Introduction of P. copri
P. copri is a Gram-negative bacteria, belonging to the phylum Bacteroidetes. The cells are anaerobic and do not form spores. P. copri is a frequent inhabitant of the human intestinal microbiome that has been both positively and negatively associated with host health. Its anaerobic qualities allow it to grow successfully in the human gut and intestines. Studies have shown that P. copri is 39.1% prevalent in healthy individuals from metagenomic profiles.
Background of P. copri as a Potential NGP
Studies on the role of gut commensal bacteria in health development have rapidly attracted much more attention beyond the classical pathogens over the last decade. The strategy of modulating the structure of the gut microbiota has been under intensive study and shed more light on the amelioration of inflammation-related diseases, cancer, and neurodegenerative diseases. While traditional probiotics generally show marginal ameliorative effects, emerging NGPs start to be revealed as new preventive and therapeutic tools.
As a potential NGP, P. copri was found to improve glucose homeostasis via intestinal gluconeogenesis. Besides, P. copri is also reported to involve exacerbation of glucose tolerance and enhance insulin resistance which occurs before the development of type 2 diabetes and ischaemic cardiovascular disease. Moreover, studies have shown a correlation between P. copri and the development of rheumatoid arthritis (RA). P. copri has been identified as highly enriched in the gut microbiota of patients with RA and an increased immune response to this organism has been demonstrated in those patients. Generally, P. copri strains may work as a beneficial bacterium, which needs further investigation.
Fig.1 Phylogenetic representation of all 1,023 P. copri genomes separated for each clade of the P. copri complex.1
Development of P. copri as a Potential NGP at Creative Biolabs
With years of experience in the research of NGPs, scientists at Creative Biolabs have paid close attention to the discovery of beneficial Bacteroides strains, exploring their interaction mechanisms with the host, and evaluating the potential safety risks during commercialization. We have perfected our technical pipelines in the development of P. copri as a potential NGP. We would like to share our knowledge and passion in this field to facilitate our customers' research and project development.
Highlights of Our P. copri Drug Discovery Services
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Lab-scale and Large-scale fermentation
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Powered by a proven, first-in-class technology
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Best after-sale service
With Ph.D. level scientists and substantial experience and expertise in the discovery of NGP, Creative Biolabs is dedicated to offering P. copri with the best quality and most competitive price. For more detailed information, please feel free to contact us.
P. copri Related Products
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CAT
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PRODUCT NAME
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PRODUCT OVERVIEW
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LBP-001FG
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Prevotella copri Powder
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Freeze-dried Prevotella copri (P. copri) Powder.
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LBST-001FG
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Prevotella copri; 13464
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Prevotella copri was isolated from human feces. Its cells are Gram-negative rods that are anaerobic and nonspore-forming.
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LBST-002FG
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Prevotella copri; Human feces (Japan)
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Prevotella copri was isolated from 52-year-old healthy man. Its cells are Gram-negative rods that are anaerobic and nonspore-forming.
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LBST-003FG
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Prevotella copri Hayashi ; Pig feces
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Prevotella copri was isolated from pig feces. Its cells are Gram-negative rods that are anaerobic and nonspore-forming.
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LBST-004FG
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Prevotella copri; Human feces
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Prevotella copri was isolated from human feces. Its cells are Gram-negative rods that are anaerobic and nonspore-forming.
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LBST-005FG
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Prevotella sp.
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Prevotella sp. was isolated from human feces. Its cells are Gram-negative rods that are anaerobic and nonspore-forming.
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LBST-006FG
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Prevotella hominis
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Prevotella hominis cells are Gram-negative, non-spore-forming, nonmotile rods and strictly anaerobic. Colonies are approximately 0.5–1mm in diameter, slightly translucent, circular, entire, slightly convex and smooth after 2 days at 37 °C on modified GAM agar plates under anaerobic conditions.
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LBST-007FG
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Prevotella stercorea
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Prevotella stercorea is an anaerobe, mesophilic, Gram-negative bacterium that was isolated from human faeces.
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LBST-008FG
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Prevotella intermedia
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Prevotella intermedia is a Gram-negative, obligate anaerobic pathogenic bacterium involved in periodontal infections, including gingivitis and periodontitis, and often found in acute necrotizing ulcerative gingivitis. Prevotella intermedia use steroid hormones as growth factors, so their numbers are higher in pregnant women.
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LBST-009FG
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Prevotella histicola
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Prevotella histicola is Gram-negative bacillus that are obligately anaerobic, vary in pigmentation and are non-motile.
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FAQs
How does P. copri influence diet and metabolism?
P. copri is noted for its ability to break down complex polysaccharides and influence metabolism, making it a key player in studies related to diet, especially high-fiber diets. It has been linked to improved glucose metabolism and potentially reduced visceral fat.
What genetic tools are available for P. copri research?
Advances have been made in developing genetic tools for P. copri, including a conjugation-based gene insertion platform, which facilitates the study of this bacterium's functions and interactions within the gut microbiota.
What methods are used for detecting and quantifying P. copri in the gut microbiota?
Techniques such as real-time quantitative PCR have been developed to detect and quantify P. copri, utilizing genome-specific primers that improve the sensitivity and specificity of detection in human fecal samples.
What potential therapeutic applications does P. copri have?
Given its association with dietary effects and immune system interactions, P. copri is being researched for its therapeutic potential in treating or managing conditions like inflammatory diseases, including rheumatoid arthritis and potentially other chronic inflammatory conditions.
How does P. copri interact with other members of the gut microbiota?
P. copri's interactions in the gut are complex, often involving competitive or synergistic relationships with other microbiota members, which can influence gut health and disease states. Understanding these interactions is key to harnessing P. copri's potential as a probiotic.
Resources
References
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Tett, Adrian, et al. "The Prevotella copricomplex comprises four distinct clades underrepresented in westernized populations." Cell host & microbe 26.5 (2019): 666-679.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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