Live Biotherapeutics Drug Discovery Services for Periodontal Disease


Periodontal diseases are pathological processes caused by infection and inflammation affecting the periodontal tissue or surrounding and supporting tissues of the tooth. Pathogenic bacteria living in complex biofilms initiate and perpetuate the disease in susceptible hosts. Conventional management of periodontitis consists of nonsurgical treatment aimed at controlling pathogenic plaque biofilm and coronal and root stone loading by mechanical manipulation while improving personal hygiene, thereby reducing inflammation and pocket depth and promoting periodontal reattachment. An individual's oral health is determined by the balance of beneficial and pathogenic bacteria, which makes the oral cavity an effective target for probiotic application. There is evidence that probiotic therapy can also alter the oral microbiome, reduce risk, or can be used to treat oral diseases. Oral probiotics play a safe, effective, and beneficial role in the treatment of oral diseases such as periodontal disease, dental caries, halitosis, orthodontics, and oral mucositis caused by cancer. The use of probiotics is an expanding area of dental research. Probiotics can effectively prevent and treat some infectious diseases in the oral cavity, such as halitosis and periodontitis, and can reduce the development of dental caries and the concentration of harmful bacteria, according to clinical studies.

Fig.1 Effects of the imbalance of the oral microbiota on systemic health. (Inchingolo, 2023)Fig.1 Effects of the imbalance of the oral microbiota on systemic health.1

Novel Treatment Strategies for Periodontal Diseases

Drugs with anti-virulence effects can inhibit the pathogenic activity of periodontal bacteria and reduce their ability to cause periodontal diseases. Targeting virulence factors of pathogenic bacteria and their regulatory systems to control pathogenicity is a promising alternative to antibiotic therapy. In recent years, with the development of the human microbiome, oral microbial replacement therapy is expected to become a new method for the prevention and treatment of periodontal disease. Probiotics that can provide new treatments are promising for the emergence of probiotics with specific sites and clear efficacy, now referred to as designer probiotics. These emerging therapies will undoubtedly change the existing models of disease prevention, control, and management. Probiotics and oral microbial replacement therapy replace periodontal innate bacteria with non-pathogenic bacteria to restore the healthy homeostasis of oral microbiota. This represents a novel disease treatment/prevention measure for transplanting microbiota from healthy donors into diseased patients.

Possible Roles of Probiotics in the Oral Cavity

In the field of stomatology, probiotics have been used to reduce dental caries, suppress oral Candida infection, and control halitosis. The mechanisms of action of probiotics include adherence to tooth surfaces and competition with cariogenic bacteria to reduce their growth and modulate microbiota composition, thereby promoting oral health, and possibly disease control through immunomodulation and colonization resistance to pathogens.

  • Antagonism with pathogens.
  • Aggregation with oral bacteria.
  • Interaction with oral epithelium.

Periodontal Health-Promoting Probiotic Species

Lactobacillus Lactobacillus acidophilus
Lactobacillus reuteri
Lactobacillus rhamnosus
Bifidobacterium Bifidobacterium animalis subsp. lactis
Streptococcus Streptococcus salivarius
Weissella Weissella cibaria
Recombinant Probiotics Recombinant Lactobacillus paracasei strain
Recombinant Lactobacillus acidophilus strain

The selection of probiotics is very important for the therapeutic effect of probiotics, and most of the selected probiotics are derived from intestinal flora or fermented foods. Bacteria of the genus Lactobacillus have been proposed as a valuable alternative biological approach to combat periodontal pathogens. Therefore, probiotics are expected to alter the periodontal plaque biofilm in the short term and thus control periodontitis. Its potential in the treatment and prevention of oral diseases such as periodontitis and dental caries has been explored with promising results. Creative Biolabs can provide probiotic strain products and some laboratory-scale customized production and testing services for oral disease research. Please feel free to contact us for further communication and more details.


  1. Inchingolo, Francesco, et al. "The Benefits of Probiotics on Oral Health: Systematic Review of the Literature." Pharmaceuticals 16.9 (2023): 1313.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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