Live Biotherapeutics Drug Discovery Service for Gingivitis
Overview
Plaque-induced gingivitis is an inflammatory condition characterized by bleeding, redness, and swelling of the gingiva. Gingivitis is divided into dental biofilm gingivitis and non-dental biofilm gingivitis. Gingivitis is caused by the accumulation of material from microbial plaque in or near the gingival sulcus. Certain species of bacteria, such as Aetinomyces, Fusobacterium, Streptococcus, Treponema, and Veillonella, and possibly Bacteroides, Eikenella, and Capnocytophaga, can cause gingivitis. Although not all established gingival lesions necessarily progress to the more advanced condition (known as periodontitis), the management of gingivitis is considered a primary prevention strategy for periodontitis. It is a reversible disease, so treatment modalities such as antimicrobial therapy, mechanical debridement, pharmacologic modification, or modification of local risk factors can be used. The goal of periodontal therapy is the prevention and treatment of periodontal inflammation and the establishment of beneficial or biofilm-associated health. The oral microbiota is a diverse group of microorganisms found in the human oral cavity, which can cause inflammation, including gingivitis and peri-implant mucositis when its balance is disrupted. In recent years, probiotic therapy and oral microbiota replacement therapy have received much attention as methods to control periodontal disease. Probiotics have been introduced in the prevention and treatment of periodontal diseases and represent an innovative approach to maintaining oral health using beneficial bacteria when administered in adequate amounts.
Probiotics in the Prevention and Treatment of Gingivitis
Probiotics can control the oral microbiota by strengthening resident bacteria and preventing the adhesion and colonization of pathogens. Studies have shown that probiotics play an important role in reducing gingival inflammation, and plaque accumulation, improving periodontal health, reducing the amount of black pigmented rods including Porphyromonas gingivalis and/or subgingival plaque in saliva, and reducing proinflammatory cytokines in patients with gingivitis. Probiotics influence oral health via different mechanisms such as immune modulation, competitive exclusion of certain pathogens, and inhibiting the adhesion of pathogenic bacteria to the oral mucosa. Probiotics can restore periodontal microbial balance, inhibit periodontal pathogens, and regulate immune response. These results suggest that probiotics can effectively improve periodontal disease and peri-implantitis. Most studies on probiotics in the periodontal literature have used Lactobacillus; in addition, Bifidobacteria are often described as effective probiotics. Their effects on oral health have been assessed. Lactobacillus plantarum MK06 probiotic suspension has good antibacterial ability, no toxicity, and no drug resistance to probiotics. It is expected to be used as an adjuvant treatment for gingivitis.
Fig.1 Properties of host modulation agent in periodontal homeostasis.1
Our Services for Gingivitis Research
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Research Articles
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Available Services
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A tangible prospect for the treatment of gingivitis using a potentially probiotic strain Lactobacillus plantarum MK06 isolated from traditional dairy products.2
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Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes.3
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Metabolites of probiotics have a positive effect on periodontal homeostasis. Future studies are needed to further investigate the role of metabolite products in periodontitis management and the long-term effects of probiotics. If you are researching the role of probiotics in the field of oral diseases, please do not hesitate to contact us, Creative Biolabs is confident to be your partner in providing you with affordable customized solutions.
References
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Deandra, Fathia Agzarine, et al. "Probiotics and metabolites regulate the oral and gut microbiome composition as host modulation agents in periodontitis: A narrative review." Heliyon (2023).
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Modiri, Sima, et al. "A tangible prospect for the treatment of gingivitis using a potentially probiotic strain Lactobacillus plantarum MK06 isolated from traditional dairy products: a triple blind randomized clinical trial." BMC Oral Health 23.1 (2023): 870.
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Ishikawa, Karin Hitomi, et al. "Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes." Journal of oral microbiology 12.1 (2020): 1805553.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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