Live Biotherapeutics Drug Discovery Service for Halitosis
Overview
Halitosis is the result of bacterial activity during the proteolytic degradation of exogenous and endogenous organic substrates by the oral anaerobes. Culturable oral bacteria associated with halitosis mainly include Porphyromonas gingivalis, Treponema forsythia, and Treponema denticola. Oral halitosis is the result of bacterial activity; therefore, probiotics may provide a suitable biological solution for the treatment of oral halitosis. Probiotics are effective in maintaining periodontal health and can also help maintain a healthy ecology of the tongue, thereby eliminating halitosis. Reducing the counts of pathogenic bacteria associated with halitosis or replacing them with colonization with probiotic strains would clarify the treatment, management, and control of halitosis.
Probiotics for Halitosis Treatment
Probiotics have been shown to play a crucial role in the prevention and treatment of several GI disorders and may have biological potential in the treatment of halitosis in the oral cavity. In recent years, probiotics such as Lactobacillus reuteri and Bifidobacterium have been widely used in the oral field, and there is increasing evidence that the application of probiotics may affect the composition of oral biofilms. Probiotics have also been studied in the treatment of periodontal disease, peri-implant disease, dental caries, oral candidiasis, and oral mucositis caused by radiotherapy and chemotherapy. Meanwhile, probiotics have also been reported as an alternative strategy to relieve halitosis, which is a relatively new treatment for halitosis. Some studies have proposed that probiotics can control plaque formation and prevent the disruption of microbial homeostasis, thereby maintaining and improving oral health.
Protective Mechanisms of Probiotics in the Halitosis
Probiotics have emerged in the field of dentistry, and the identification and selection of probiotics based on the source of oral commensal flora may be the best strategy for the prevention or even treatment of oral diseases by probiotics. Strains used as probiotics must be able to adhere to oral hard and/or soft tissues or other bacteria to exert their effects. In addition, probiotic strains must compete with oral microorganisms for nutrients and/or produce metabolic substances with selective antimicrobial activity. Probiotics can also play a role by stimulating local immunity, regulating inflammatory responses, and altering epithelial permeability. The co-aggregation ability of probiotic strains against oral pathogenic bacteria may provide a broader application for alleviating the symptoms of halitosis by improving the co-aggregation and/or colonization of specific probiotics against volatile sulfur compounds producing oral pathogenic bacteria.
Fig.1 Possible mechanisms of probiotics in the prevention of halitosis.1
Our Services for Halitosis Research
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Research Article
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Available Services
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Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro.2
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Measurement of volatile sulfur compounds (VSCs) synthesis
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The antimicrobial test of S. salivarius
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The modulation of the microbiota through the use of probiotics or a new generation of beneficial microbes constitutes a prospect for the development of medical tools for the maintenance of health. Creative Biolabs is committed to providing the analytical or testing solutions you may need throughout the entire lifecycle of live biotherapeutics or probiotic product research, development, and quality control. We are experts in the analysis and laboratory-scale production of probiotics and next-generation probiotics. Please contact us for more details.
References
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Karbalaei, Mohsen, et al. "Alleviation of halitosis by use of probiotics and their protective mechanisms in the oral cavity." New microbes and New infections 42 (2021): 100887.
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Yoo, Hyun‐Jun, et al. "Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro." Clinical and experimental dental research 6.2 (2020): 207-214.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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