Human Health & Antifungal Solutions

Q: What kind of in vitro and in vivo models do you utilize for testing antifungal efficacy relevant to human health?

We employ a comprehensive suite of in vitro models, including MIC/MFC determination, time-kill assays, and biofilm studies. Our in vivo capabilities include a variety of immunocompromised and immunocompetent animal models of systemic, localized, and dermatological fungal infections, designed to closely mimic human disease states.

Q: Do you have experience working with novel antifungal drug targets and mechanisms of action beyond traditional approaches?

Absolutely. Our scientific team is at the forefront of antifungal research, actively exploring and validating novel targets and mechanisms, including those aimed at overcoming existing resistance mechanisms or modulating host immune responses. We are equipped to develop custom assays for your innovative compounds.

Fungal infections are a major and increasingly serious global health challenge, affecting millions of people and causing a large number of morbidity and mortality rates. From common skin conditions to life-threatening systemic diseases, the need for innovative and effective antifungal solutions has never been more urgent. At Creative Biolabs, we are at the forefront of this critical fight, offering comprehensive Contract Research Organization (CRO) services dedicated to accelerating the discovery and development of next-generation antifungal therapies. Request a quote

The Unseen Burden: Why Antifungal Research Matters

Fungal infections, often overshadowed by bacterial and viral diseases, pose a unique threat due to their increasing prevalence, the emergence of drug-resistant strains, and the limited pipeline of new therapeutic agents. This global health crisis underscores the critical importance of dedicated research and development in the antifungal space. Our mission is to partner with pharmaceutical and biotechnology companies, academic institutions, and government organizations to overcome these challenges and bring life-saving treatments to patients worldwide.

Understanding Fungal Threats: From Superficial to Invasive

Fungal infections manifest in various forms, ranging in severity and impact. Our expertise spans the full spectrum of mycotic diseases, enabling us to provide tailored research solutions.

Fig.1 Fungal invasion infection. (Creative Biolabs Authorized)

Invasive Fungal Infection (IFI)

IFIs are severe, life-threatening infections that occur when fungi invade deeper tissues or organs, often spreading throughout the body. Common IFIs include invasive candidiasis, aspergillosis, cryptococcosis, and mucormycosis, with mortality rates often exceeding 50%. The development of new systemic antifungal agents with novel mechanisms of action and improved safety profiles is paramount in this area.

Superficial & Mucocutaneous Mycosis

These are common fungal infections that affect the skin, nails, hair, and mucous membranes. Although they are usually not life-threatening, they can cause severe discomfort, and disfigurement and affect the quality of life. Examples include athlete's foot, ringworm, yeast infections (e.g., vaginal candidiasis), and oral thrush. Research in this area focuses on developing topical and oral agents with improved efficacy, and reduced side effects.

Fig.2 Superficial fungal infection. (Creative Biolabs Authorized)

Our Comprehensive CRO Services for Antifungal Solutions: Discovery & Preclinical Research

Target Identification and Validation: Identifying novel fungal targets for drug intervention.
High-Throughput Screening (HTS): Rapid screening of compound libraries to identify potential antifungal hits.
In Vitro Efficacy Assays
- MIC and MFC determination against diverse fungal strains, including resistant isolates.
- Time-kill assays to assess the rate of fungal killing.
- Synergy studies with existing antifungals.
- Biofilm inhibition and eradication assays.
- Mechanism of Action (MOA) studies to elucidate how compounds exert their antifungal effects.
In Vivo Efficacy Models: Establishment and execution of relevant animal models for various fungal infections (e.g., disseminated candidiasis, aspergillosis, dermatophytosis) to assess compound efficacy, pharmacokinetics (PK), and pharmacodynamics (PD).
Resistance Profiling: Studying the mechanisms of antifungal resistance and evaluating compounds against resistant fungal strains.
Pharmacology & Toxicology: Comprehensivein vitro and in vivo studies to assess drug metabolism, absorption, distribution, excretion (ADME), and potential toxicity.

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The Science Behind Antifungal Action: Mechanisms of Action

Antifungal drugs work by targeting unique components of fungal cells that are absent or significantly different in human cells, thereby minimizing toxicity to the host. Understanding these mechanisms is crucial for designing new and effective therapies.

Ergosterol Synthesis Inhibition: Ergosterol is an important component of fungal cell membranes, similar to cholesterol in human cells. Many antifungal drugs, such as azole and allylamine, inhibit the enzymes involved in ergosterol biosynthesis, leading to impaired cell membrane integrity and the death of fungal cells.
Cell Membrane Disruption: Polyenes directly combine with ergosterol on the fungal cell membrane to form stomata, leading to intracellular component leakage and cell lysis.
Cell Wall Synthesis Inhibition: The fungal cell wall provides structural integrity and protection. Echinocandins weaken the cell leading to its demise.
Nucleic Acid Synthesis Inhibition: There is already an antimetabolite drug that interferes with the synthesis of fungal DNA and RNA, thereby inhibiting the growth and replication of fungi.

Why Partner with Creative Biolabs? Our Distinct Advantages

Deep Expertise: Our team comprises seasoned mycologists, microbiologists, and pharmacologists with extensive experience in antifungal drug discovery and development.
State-of-the-Art Facilities: We boast cutting-edge laboratories equipped with advanced technologies for both in vitro and in vivo studies, including BSL capabilities where required.
Comprehensive Service Portfolio: From early-stage discovery to late-phase preclinical trials, we offer a complete suite of services to support your entire drug development pipeline.
Customized Solutions: Adherence to the highest industry standards, ensures the integrity and reliability of your data.
Quality & Compliance: Adherence to the industry standards, ensures the integrity and reliability of your data.
Accelerated Timelines: Our streamlined processes and proactive project management aim to significantly reduce development timelines, bringing your innovations to patients faster.

Fig.3 Analysis of antifungal drugs. (Creative Biolabs Authorized)

Target Customer Groups

Pharmaceutical and Biotechnology Companies: Seeking to outsource or augment their internal R&D capabilities for antifungal drug discovery and development.
Academic and Research Institutions: Requiring specialized expertise and infrastructure for advanced fungal research.
Start-ups and Emerging Biotechs: Looking for a reliable partner to accelerate their novel antifungal programs.

Connect with Our Experts Today!

Are you ready to accelerate your antifungal research and bring life-changing solutions to patients? Contact us today to discuss your project needs and learn how Creative Biolabs can be your trusted partner in the fight against fungal infections.

FAQs

What kind of in vitro and in vivo models do you utilize for testing antifungal efficacy relevant to human health?

Do you have experience working with novel antifungal drug targets and mechanisms of action beyond traditional approaches?

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Accelerate Human Health: Antifungal Solutions & CRO Services