Animal Health & Antifungal Solution

Q: What types of animal fungal infections do you specialize in?

We have extensive experience with a wide range of animal fungal infections, including but not limited to aspergillosis, candidiasis, cryptococcosis, histoplasmosis, blastomycosis, coccidioidomycosis, and dermatophytoses in various species.

Q: How do you address the challenge of antifungal resistance in your research?

We employ a multi-faceted approach, including screening for novel mechanisms of action, evaluating combination therapies, and rigorously monitoring for resistance development throughout the research process.

Q: What is your approach to ensuring data quality and integrity?

We implement robust quality control measures, utilize validated assays, and adhere to principles to ensure the highest standards of data quality and integrity.

Fungal infections represent a significant and growing threat to animal health worldwide, impacting companion animals, livestock, and even aquatic species. These infections cause substantial economic losses, compromise animal welfare, and, in some cases, pose zoonotic risks to human health. At Creative Biolabs, we are at the forefront of accelerating research and development in animal health antifungal solutions, leveraging our comprehensive expertise and state-of-the-art facilities to bring novel and effective therapies to market faster. Request a quote

The Critical Need for Advanced Antifungal Solutions in Animal Health

Fungal diseases in animals can manifest in various forms, from superficial skin infections to life-threatening systemic mycoses. The increasing prevalence of antifungal resistance, driven by both agricultural and medical use of antifungal agents, further complicates treatment and underscores the urgent need for new drug candidates with novel mechanisms of action. Climate change and global trade patterns have also contributed to the spread of fungal pathogens, making the "One Health" approach that recognizes the interconnections among humans, animals and environmental health more important than ever.

Fig.1 Solutions for fungal infections in cattle. (Creative Biolabs Authorized)

Our Role in Accelerating Your Success: Comprehensive CRO Services

In Vitro Services

In Vivo Services

In Vitro Antifungal Screening

High-Throughput Screening (HTS): Rapid screening of large compound libraries against diverse panels of animal fungal pathogens (yeasts, molds, dermatophytes), including resistant strains.
Susceptibility Testing: Determination of Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) against a wide range of relevant fungal species.
Mechanism of Action Studies: Elucidating the precise cellular targets and pathways affected by novel antifungal compounds.
Resistance Profiling: Identifying and characterizing mechanisms of resistance to new and existing antifungals.
Biofilm Assays: Evaluating antifungal activity against fungal biofilms.
Drug Combination Studies: Assessing synergistic or antagonistic effects of antifungal combinations.

In Vivo Efficacy Models

Validated Animal Models: Established and custom-developed disease models for various animal species to mimic natural fungal infections (e.g., systemic candidiasis, aspergillosis, dermatophytosis, cryptococcosis).
Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Characterizing drug absorption, distribution, metabolism, excretion (ADME) and correlating drug exposure with therapeutic outcomes in target tissues.
Dose-Response Studies: Determining optimal dosing regimens for maximum efficacy and minimal toxicity.
Toxicology and Safety Assessments: Comprehensive evaluation of drug safety and tolerability in relevant animal species.

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Understanding the Enemy: Mechanism of Action of Antifungal Agents

Ergosterol Synthesis Inhibition: Azoles and allylamines inhibit the synthesis of ergosterol, this disruption leads to increased cell membrane permeability and ultimately cell death.
Cell Wall Disruption: Echinocandins target the major component of the fungal cell wall, leading to structural instability and lysis.
Nucleic Acid Synthesis Inhibition: Flucytosine interferes with fungal DNA and RNA synthesis.
Membrane Permeability Alteration: Polyenes bind directly to ergosterol in the fungal cell membrane, creating pores that lead to leakage of intracellular components and cell death.

Why Partner with Creative Biolabs?

Fig.2 Research on antifungal drugs in the field of animal health. (Creative Biolabs Authorized)

Deep Scientific Expertise
State-of-the-Art Facilities
Integrated Approach
Customized Solutions

Target Customer Groups

Pharmaceutical and Biotechnology Companies: Seeking to develop and commercialize new antifungal drugs for animals.
Veterinary Diagnostic Companies: Looking to validate new diagnostic tools or explore novel therapeutic approaches.
Academic and Research Institutions: Require specialized CRO support for their antifungal research projects.
Animal Health Start-ups: Benefiting from our comprehensive expertise to efficiently navigate the drug development pathway.

Partner with Us to Accelerate Animal Health

The fight against fungal infections in animals demands innovative solutions and a steadfast commitment to scientific excellence. At Creative Biolabs, we are dedicated to partnering with you to bring life-changing antifungal therapies to animals in need. Our integrated expertise, cutting-edge technology, and client-centric approach ensure that your research journey is efficient, effective, and ultimately successful. Contact us immediately to discuss your specific research needs and learn how we can be your trusted partner to accelerate the development of animal health and antifungal solutions.

FAQs

What types of animal fungal infections do you specialize in?

How do you address the challenge of antifungal resistance in your research?

What is your approach to ensuring data quality and integrity?

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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

Accelerate Animal Health: Antifungal Solution & CRO Service