Prevotella stercorea is an anaerobe, mesophilic, Gram-negative bacterium that was isolated from human faeces.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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LBST-007FG |
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Product Information | |
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Product Overview | Prevotella stercorea is an anaerobe, mesophilic, Gram-negative bacterium that was isolated from human faeces. |
Target | Prevotella |
Genus | Prevotella |
Strain Designation | CB35 |
Application | Study and research |
Culture Medium | Blood agar |
Culture Conditions | 37°C; Anaerobic |
Source | Human faeces |
Risk Group | 1 |
Product Format | Freeze-dried |
Packaging | Ampoule tube |
Storage | -80°C |
Shelf Life | 6 years |
Target Introduction | |
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Introduction | Prevotella is a genus of anaerobic Gram-negative bacteria of the Bacteroidetes phylum, which also includes the clinically important genera Bacteroides and Porphyromonas. Prevotella strains are classically considered commensal bacteria due to their extensive presence in the healthy human body and their rare involvement in infections. Prevotella spp. are members of the oral, vaginal, and gut microbiota and are often recovered from anaerobic infections of the respiratory tract. Prevotella spp. predominate in periodontal disease and periodontal abscesses. Regarding Prevotella, studies focused on the associations between the diverse species, genome and habitats with dietary patterns, health and disease. Evidence revealed beneficial effects of some Prevotella strains in the gut such as improving CVD risk factor profile and glucose metabolism. Most studies reported that vegetarians harbour higher numbers of Prevotella species as well as a high Prevotella/Bacteroides ratio compared with non-vegetarians; omnivores. Nevertheless, there is a need for more studies in humans to ascertain a causal and potential disease-triggering role for Prevotella and more in-depth metagenomic studies are needed in order to reveal the health- or disease-modulating properties. |
Alternative Names | Prevotella stercorea |
Prevotella stercorea is primarily used in research to study its role in the human gut microbiome, its potential implications in inflammatory bowel diseases, and its interactions with other gut microorganisms. It is also investigated for its impact on metabolic processes and systemic health.
Prevotella stercorea influences gut microbiota composition by promoting the growth of other beneficial bacteria and producing metabolites that support a healthy gut environment. It plays a crucial role in carbohydrate metabolism, contributing to the overall diversity and functionality of the gut microbiome.
Distinguishing characteristics of Prevotella stercorea include its anaerobic nature, its ability to degrade complex carbohydrates, and its production of short-chain fatty acids. These traits are essential for researchers studying gut health, microbial ecology, and metabolic interactions within the microbiome.
When using Prevotella stercorea in research, it is important to ensure proper strain identification, assess its pathogenic potential, and evaluate any possible antibiotic resistance. Researchers should conduct thorough in vitro and in vivo assessments to ensure the safety and reliability of their findings.
Common methodologies to study Prevotella stercorea include genomic sequencing to understand its genetic makeup, in vitro culture techniques to observe its metabolic capabilities, and animal models to investigate its role in gut health and disease. These methods help researchers gain a comprehensive understanding of its functions and potential applications.
Distribution of carbohydrate active enzyme (CAZy) families in human gut Prevotella (average copies per genome)
The study investigates the diversity and functional roles of Prevotella species in the human gut, focusing on Prevotella stercorea. The research utilized publicly available gut metagenomes to map the presence and relative abundance of various Prevotella species, finding that while Prevotella copri is most common, Prevotella stercorea is also significantly prevalent. Genetic analyses revealed that Prevotella stercorea lacks many hemicellulose-degrading enzymes present in P. copri, indicating a different metabolic niche. Instead, Prevotella stercorea possesses carbohydrate esterases, suggesting its role in modifying carbohydrates to facilitate degradation by other gut bacteria.
Experimental data highlighted that Prevotella stercorea and its related lineages are more abundant in non-Western populations, which might be linked to high-fiber diets typical of these communities. The presence of unique carbohydrate esterases in Prevotella stercorea genomes supports its potential role in dietary fiber metabolism, particularly in cooperation with other gut microbes. This study underscores the importance of characterizing lesser-known gut microbiota like Prevotella stercorea, as they contribute to the metabolic diversity and overall function of the gut ecosystem. The findings suggest that these bacteria play crucial roles in the gut microbiome, influencing human health and disease.
Yeoh, Y. K., Sun, Y., et al. Prevotella species in the human gut is primarily comprised of Prevotella copri, Prevotella stercorea and related lineages. Scientific reports. 2022, 12(1): 9055.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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