Live Biotherapeutics Drug Discovery Services for Obesity
The gut microbiome has been identified as one of the most important factors in obesity pathogenesis and regulation. As a world-leading services provider, Creative Biolabs is confident in providing a full range of probiotic products and high-efficiency services for obesity treatment and prevention.
Overview of Obesity
Obesity or overweight is medically considered as a kind of chronic metabolic disease in which abnormal or excessive fat accumulates causing multiple adverse effects on human health. Over the past few decades, the prevalence of obesity worldwide has more than tripled since 1975, leading to current approximately one-third of the population now living with obesity. As a major public health problem, obesity is known to cause a series of human diseases and pathologies, among which cardiovascular diseases, diabetes, fatty liver, cancers are the most common types.
Fig.1 Obesity and its medical complications.
Role of Gut Microbiota in Obesity
There are many factors causing obesity, mainly including excessive intake of energy, lifestyle, genetics, other diseases, lack of sleep, and so forth. Among these causes, the gut microbiota is a recently identified factor of obesity and obesity-related metabolic disorders. Microbiota colonized in the human intestinal tract is implanted to the pathogenesis of obesity through multiple proposed mechanisms (see Fig.2):
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Protect and increase the permeability of gastrointestinal mucosa;
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Increased lipopolysaccharides (LPS) in the gastrointestinal tract results in enhanced circulating LPS levels, inducing low-grade inflammation and insulin resistance;
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Gut microbiota, such as Bacteroides spp., ferment dietary polysaccharides and fiber to yield short-chain fatty acid (SCFA), offering the host with an additional source of energy;
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Involve in the control of energy intake and modulation of the nervous system.
Fig.2 Impact of gut microbiota on local and distant organs contributes to obesity development and progression. (Sun, 2018)
Probiotics: a New Path for Obesity Treatment
It has been validated that gut microbiota and gut microbiota composition not only play considerable actions in the pathogenesis of obesity but also plays a key role in obesity modulation. Gut microbiota has emerged as a potential target that plays an important role in the prevention and treatment of obesity. Numbers of studies have been conducted to explore and develop obesity treatment by a diversity of probiotics, such as Lactobacillus spp., Bifidobacterium spp., Akkermansia muciniphila, etc.
Creative Biolabs is proud to be one of your trusted partners in live biotherapeutics drug discovery. Our talented scientists with innovative technology platforms are always ready to provide fully custom services for the prevention and treatment of obesity and obesity-related metabolic disorders using potential probiotics. In addition to a spectrum of probiotic products, a wide range of custom analytical development and qualification services are also within our scope, which mainly include but not limited to:
Please feel free to contact us and our experienced technicians will give you the most detailed solutions.
Reference
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Sun, L.J., et al. Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives. Protein Cell. 2018, 9(5): 397-403.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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