Live Biotherapeutics Drug Discovery Service for Hepatotoxicity
Creative Biolabs is based in New York, USA. We focused on developing technical services in the research area of live biotherapeutics. The objective of our organization is to facilitate and expedite the research endeavors of life science researchers worldwide by providing superior products and services.
Overview
Increasing evidence has shown that intestinal flora plays an important role in maintaining liver health. Probiotics play a preventive role in liver injury by restoring intestinal flora, increasing the integrity of the intestinal wall, and reducing endotoxemia, bacterial translocation, and epithelial invasion. Thus, modulation of the gut microbiota can simultaneously activate cathelicidin production and stimulate host immunity, representing a potential approach to liver protection. In addition, probiotics attenuate oxidative and inflammatory liver injury. Probiotics and post-probiotics have shown promise in rescuing liver disease and exogenous hepatotoxicity as well as restoring normal liver function.
Hepatoprotective Mechanisms of Probiotics
Probiotics have therapeutic effects on a variety of liver diseases, including cirrhosis, hepatic encephalopathy, sclerosing cholangitis, fatty liver disease (alcoholic and non-alcoholic), hepatocellular carcinoma, etc. Probiotics can inhibit hepatic oxidative stress, which is a common pathological phenomenon in a variety of liver diseases. In addition, probiotics can improve intestinal barrier integrity and prevent liver transfer of pathogenic bacteria. Therefore, it can be said that probiotics exert liver protection through multiple mechanisms.
Fig.1 Protective mechanism of probiotics against APAP hepatotoxicity.1
Probiotics and Hepatotoxicity
Different probiotics have different protective mechanisms against acetaminophen (APAP) hepatotoxicity.
E. lactis has a protective effect on APAP-induced hepatocyte injury, and the mechanism may be related to the antioxidant effect of this probiotic.
S. thermophilus could reduce the levels of ALT, AST, and ALP in the serum of experimental rats, which proved its hepatoprotective effect.
Akkermansia muciniphila can alleviate APAP-induced acute liver injury by regulating intestinal flora and metabolism, inhibiting oxidative stress and inflammatory response, and regulating various signaling events.
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar Hepatotoxicity Research
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Research Article
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Available Services
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Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.2
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Acute liver failure (ALF) model
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Construction of the β-galactosidase knockout L. vaginalis strain
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Fecal microbiota transplantation
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Ex vivo fermentation experiment
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Biochemical and ELISA assays
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qRT-PCR
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Determination of reactive oxygen species
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16S rRNA gene sequencing analysis
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Hepatoprotective effects of lactobacillus on carbon Tetrachloride-induced acute liver injury in mice.3
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Evaluation of gastrointestinal tolerability in vitro
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Animal models and treatment
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Measurement of biochemical parameters in serum
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Creative Biolabs provides high-quality contract research services and products to pharmaceutical and biotechnology companies, governments, and academic institutions, and is a flexible, customized solution tailored to the research objectives of scientists. Our competitive advantage lies in our experience and ability to specify solutions to our clients quickly and efficiently. If you are interested in our services or products, please do not hesitate to contact us for more details.
References
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Dewanjee, Saikat, et al. "Probiotics: evolving as a potential therapeutic option against acetaminophen-induced hepatotoxicity." Biomedicines 10.7 (2022): 1498.
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Zeng, Yunong, et al. "Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice." Cell Host & Microbe 31.5 (2023): 766-780.
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Chen, Xiaoyong, et al. "Hepatoprotective effects of Lactobacillus on carbon tetrachloride-induced acute liver injury in mice." International journal of molecular sciences 19.8 (2018): 2212.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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