Live Biotherapeutics Drug Discovery Service for Anorexia
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Overview
Anorexia nervosa (AN) is an eating disorder characterized by significant weight loss, impaired body image, and an intense fear of weight gain. It is associated with morbidity in patients and their caregivers and has one of the highest mortality rates among mental health disorders. In AN, the composition of the innate gut microbiota and its changes due to improper dietary intake may be responsible for the impaired immune and anti-inflammatory responses. Compared with patients without eating disorders (EDs), the composition of gut microbiota in AN patient is significantly different, and the relative abundance of Gram-positive bacteria/Gram-negative bacteria is unbalanced. Microbiome alterations have been found to play a causal role in anxiety disorders, depression, and stress responses, which are important symptoms or comorbidities of AN. The gut microbiome and its role in the gut-brain axis are being investigated in mental health disorders. The composition and function of the gut microbiota are targets for novel therapies for many diseases, including AN. Therefore, the use of probiotics in AN may be a useful adjunct to current treatment.
AN and the Gut Microbiome
Human gut microbiota is gradually becoming a key regulator of homeostasis, which has a profound impact on a variety of multifactorial diseases, including AN. Studies have shown that the microbial diversity and composition of AN patients differ from overweight/obese controls and healthy individuals. The total number of bacteria, for example, of butyrate-producers, such as Roseburia, is reduced compared to controls. In contrast, mucin-degrading bacteria such as Akkermansia muciniphila and Methanobrevibacter smithii increased in abundance. Bacteroidetes, Firmicutes, Verrucomicrobia, Proteobacteria, and Actinobacteria are the dominant phyla in the intestinal flora of AN patients. The flora was similar to that of normal weight controls. The gut microbiota of AN patients may be a consequence of the premorbid composition of the gut microbiota. It was indicated that probiotics such as Roseburia, which play a role in butyrate synthesis, can be applied in the treatment of anorexia nervosa in the future. Another potential strategy for regulating gut microbiota composition and preventing dysbiosis in anorexia nervosa is fecal microbiota transplantation (FMT).
Fig.1 Putative role of the gut microbiota in the onset and maintenance of AN.1
Next-generation Probiotic Strains at Creative Biolabs
Creative Biolabs can offer a range of next-generation probiotics for live biotherapeutics research, including but not limited to the following, click on Probiotic Strains to check out more strains you might be interested in.
Our Services for the Following Type/Similar Anorexia Research
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Research Article
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Available Services
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Gut microbiota mediates Lactobacillus rhamnosus GG alleviation of deoxynivalenol-induced anorexia.2
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Gut microbiota alteration in a mouse model of anorexia nervosa.3
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References
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Breton, Jonathan, Pierre Déchelotte, and David Ribet. "Intestinal microbiota and anorexia nervosa." Clinical Nutrition Experimental 28 (2019): 11-21.
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Bai, Yongsong, et al. "Gut Microbiota Mediates Lactobacillus rhamnosus GG Alleviation of Deoxynivalenol-Induced Anorexia." Journal of Agricultural and Food Chemistry (2023).
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Breton, Jonathan, et al. "Gut microbiota alteration in a mouse model of Anorexia Nervosa." Clinical Nutrition 40.1 (2021): 181-189.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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