Ruminococcus gnavus as Next Generation Probiotics
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Introduction of Ruminococcus gnavus (R. gnavus)
R. gnavus can be found in the gastrointestinal tracts of animals and humans. It is an important mucin-degrading bacterium and a prominent microorganism in the gut of infants. R. gnavus, a strictly anaerobic Gram-positive bacterium belonging to the Lachnospiraceae family, provides its own unique carbon source by expressing intramolecular trans-sialidases to degrade mucus.
The researchers investigated the effect of orally administered R. gnavus on antibiotic treatment-induced gut dysbiosis in a mouse model of AD. The mice were administered antibiotic cocktails for 2 weeks. R. gnavus was administered orally throughout the study period. At 6 weeks of age, ovalbumin sensitizes the epidermis and causes AD. The results showed that orally administered R. gnavus significantly reduced AD-associated parameters. The findings suggested that R. gnavus administration may modulate the Th2-related allergic inflammation in AD by inducing changes in SCFA-related and Treg-mediated immune pathways in the gut. The results provide a new therapeutic perspective on the immune function of R. gnavus in AD.
Fig.1 Effects of R. gnavus on the epidermal permeability barrier and skin histology in the antibiotic-treated AD mice model. (Ahn, 2022)
What Services Can We Provide for R. gnavusat Creative Biolabs?
R. gnavus Related Products at Creative Biolabs
We supply a variety of R. gnavus strains of different preservation numbers as below. If you need other strains, please contact us.
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Customized strain culture supernatant. (e.g.: for animal research)
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Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)
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Reference
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Ahn, J.R.; et al. Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice [J]. Pediatric Allergy and Immunology, 2022, 33(1): e13678.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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