Ruminococcus gnavus as Next Generation Probiotics
Background R. gnavus for AD Services Products FAQs Resources
Introduction of Ruminococcus gnavus (R. gnavus)
Creative Biolabs is headquartered in the USA, but we have a worldwide customer base and a reputation as a leading live biotherapeutic products (LBPs) specialist. We offer LBP development services for discovery research. A cooperation with us promises a fast project processing according to the highest quality standards.
Introduction of Ruminococcus gnavus (R. gnavus)
R. gnavus can be found in the gastrointestinal tracts of animals and humans. It is an important mucin-degrading bacterium and a prominent microorganism in the gut of infants. R. gnavus, a strictly anaerobic Gram-positive bacterium belonging to the Lachnospiraceae family, provides its own unique carbon source by expressing intramolecular trans-sialidases to degrade mucus.
The researchers investigated the effect of orally administered R. gnavus on antibiotic treatment-induced gut dysbiosis in a mouse model of AD. The mice were administered antibiotic cocktails for 2 weeks. R. gnavus was administered orally throughout the study period. At 6 weeks of age, ovalbumin sensitizes the epidermis and causes AD. The results showed that orally administered R. gnavus significantly reduced AD-associated parameters. The findings suggested that R. gnavus administration may modulate the Th2-related allergic inflammation in AD by inducing changes in SCFA-related and Treg-mediated immune pathways in the gut. The results provide a new therapeutic perspective on the immune function of R. gnavus in AD.
Fig.1 Effects of R. gnavus on the epidermal permeability barrier and skin histology in the antibiotic-treated AD mice model.1
What Services Can We Provide for R. gnavusat Creative Biolabs?
R. gnavus Related Products at Creative Biolabs
We supply a variety of R. gnavus strains of different preservation numbers as below. If you need other strains, please contact us.
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Customized strain culture supernatant. (e.g.: for animal research)
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Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)
Creative Biolabs offers a variety of services for research scientists. We take pride in our high standard of quality and we transparently share our data. If you are seeking an LBP development service lab to partner with, look no further. Please feel free to contact us to get better results.
FAQs
What therapeutic potentials does R. gnavus hold as a next generation probiotic?
R. gnavus shows promise in modulating Th2-related allergic inflammation in atopic dermatitis and possibly other chronic inflammation-related conditions. Its mechanisms likely involve changes in short-chain fatty acid (SCFA) profiles and regulatory T-cell-mediated immune pathways in the gut.
What unique capabilities does Creative Biolabs offer for the discovery of R. gnavus as a probiotic?
Creative Biolabs specializes in the discovery phase of next-generation probiotics with services like high-throughput microbial screening and advanced molecular identification techniques. This allows for precise characterization and optimization of R. gnavus strains for specific therapeutic applications, highlighting their role in the industry as a leader in microbial biotechnology.
How does Creative Biolabs support the scale-up production of R. gnavus strains?
The company provides tailored scale-up production services, which include lab-scale production and downstream process development. This comprehensive approach ensures that once a particular strain of R. gnavus is identified as potentially beneficial, it can be produced in quantities sufficient for extensive research and pre-clinical trials, thus accelerating the path from discovery to application.
Can Creative Biolabs customize R. gnavus probiotics for specific research needs?
Yes, Creative Biolabs can customize R. gnavus strains according to specific research requirements, including modifying their growth media, genetic makeup, or metabolite profiles. This customization capability allows researchers to study the effects of specific probiotic characteristics on various health conditions more effectively.
Can R. gnavus be used in clinical settings?
Currently, R. gnavus is intended for research use only and is not approved for clinical use in humans. It is primarily used in academic and industrial research settings to explore its potential therapeutic benefits and mechanism of action within the gut microbiome.
Resources
Reference
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Ahn, J.R.; et al. Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice [J]. Pediatric Allergy and Immunology, 2022, 33(1): e13678.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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