Ruminococcus gnavus as Next Generation Probiotics

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Introduction of Ruminococcus gnavus (R. gnavus)

R. gnavus can be found in the gastrointestinal tracts of animals and humans. It is an important mucin-degrading bacterium and a prominent microorganism in the gut of infants. R. gnavus, a strictly anaerobic Gram-positive bacterium belonging to the Lachnospiraceae family, provides its own unique carbon source by expressing intramolecular trans-sialidases to degrade mucus.

R. gnavus for Atopic Dermatitis (AD)

The researchers investigated the effect of orally administered R. gnavus on antibiotic treatment-induced gut dysbiosis in a mouse model of AD. The mice were administered antibiotic cocktails for 2 weeks. R. gnavus was administered orally throughout the study period. At 6 weeks of age, ovalbumin sensitizes the epidermis and causes AD. The results showed that orally administered R. gnavus significantly reduced AD-associated parameters. The findings suggested that R. gnavus administration may modulate the Th2-related allergic inflammation in AD by inducing changes in SCFA-related and Treg-mediated immune pathways in the gut. The results provide a new therapeutic perspective on the immune function of R. gnavus in AD.

Effects of <em>R. gnavus</em> on the epidermal permeability barrier and skin histology in the antibiotic-treated AD mice model. Fig.1 Effects of R. gnavus on the epidermal permeability barrier and skin histology in the antibiotic-treated AD mice model. (Ahn, 2022)

What Services Can We Provide for R. gnavusat Creative Biolabs?

R. gnavus Related Products at Creative Biolabs

  • Strain Products

We supply a variety of R. gnavus strains of different preservation numbers as below. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs offers a variety of services for research scientists. We take pride in our high standard of quality and we transparently share our data. If you are seeking an LBP development service lab to partner with, look no further. Please feel free to contact us to get better results.

Reference

  1. Ahn, J.R.; et al. Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice [J]. Pediatric Allergy and Immunology, 2022, 33(1): e13678.

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