Streptococcus dentisani 7746 and 7747 as Next Generation Probiotics
S. dentisani for Dental Caries Products FAQs Resources
Streptococcus dentisani for Dental Caries Therapy
While traditional probiotics generally show marginal ameliorative effects, emerging next-generation probiotics (NGPs) start to reveal as a new preventive and therapeutic tool. Streptococcus dentisani 7746 and 7747 is of major importance in the therapeutic of dental caries. Creative Biolabs will guide you through the identification & characterization and lab-scale production of novel and disease-specific NGPs.
Streptococcus dentisani for Dental Caries Therapy
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New Prevention Method
Oral diseases such as dental caries and periodontitis are caused by microorganisms. It has been pointed out that antimicrobial strategies may not be effective for oral diseases, and new prevention or treatment methods based on restoring the oral microbial ecological balance have been proposed. Those new preventive measures may include the use of prebiotic compounds to encourage the growth of health-related bacteria or the application of probiotic bacteria with beneficial features. In the case of dental caries, health-related microbial communities have been identified by using omics approaches. Culturing these microorganisms may provide potential beneficial bacteria to prevent oral diseases.
Fig.1 Scanning electron microscopy (SEM) of three oral pathogens before (left) and after (right) a 30-min treatment with 10-fold concentrated supernatant of S. dentisani 7746.1
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Bacteriostatic Principle
Studies have shown that Streptococcus dentisani could inhibit the growth of caries-producing bacteria (such as Streptococcus mutans and Streptococcus sobrinus) and buffer extracellular acidic pH value, which is the underlying cause of dental caries. The reason is that strains T contain the key genes of the arginine deiminase system: arcA, arcC, and arcB. They participate in the ammonia generation through arginine metabolism, a mechanism that releases ammonia extracellularly producing the alkalinization of the environment.
Fig.1 Potential buffering effect in the oral cavity due to the enrichment of the dental plaque bacterial community with Streptococcus dentisani.2
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Bacteriostatic Result
The antibacterial activity of S. dentisani supernatants showed: the addition of the S. dentisani 7746 concentrated supernatants produced an inhibitory effect on the growth of both S. mutans and S. sobrinus, as compared to the curves obtained when only concentrated brain heart infusion medium (BHI) was added. Similarly, the growth of S. mutans strains was completely inhibited by the concentrated supernatant. S. dentisani 7746 had the same results.
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Observation Result
Microscopic observation showed that the cells of S. mutans, S. nucleatus and P. intermedia were affected after 30 min of incubation by concentrated supernatants of S. dentisani. We can see pores in the surface of the cells (S. mutans), changes in the cell walls' structure (P. intermedia), and cell lysis (F. nucleatum).
Creative Biolabs has a wealth of experience in NGPs' discovery. For each test, such as bacterial genetic features and physiological traits, growth dynamics, antibiotics sensitivity pattern tests, and screening and isolation of NGPs, we can provide valuable scientific support. If you have any scientific research requirements or questions, please feel free to contact us.
Related Products
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CAT
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Product Name
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Product Overview
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LBST-097FG
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Streptococcus oralis subsp. dentisani; 7746
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Streptococcus oralis subsp. dentisani is a microaerophile, mesophilic, Gram-positive human pathogen that was isolated from human caries-free tooth surface.
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FAQs
What makes Streptococcus dentisani suitable for use as next generation probiotics in dental health?
Streptococcus dentisani strains have shown potential in preventing dental caries due to their ability to inhibit the growth of cariogenic bacteria like Streptococcus mutans and buffer acidic pH in the oral cavity. Their effectiveness comes from the arginine deiminase system, which helps in ammonia production and environmental alkalinization.
What are the scientific challenges in developing Streptococcus dentisani as a commercial probiotic?
Developing Streptococcus dentisani into a commercial probiotic involves overcoming challenges such as ensuring strain stability, efficacy in diverse oral environments, and compliance with regulatory requirements for safety and effectiveness. Continuous research is needed to address these aspects and facilitate its use in preventive oral healthcare.
What specialized services does Creative Biolabs provide for Streptococcus dentisani probiotics development?
Creative Biolabs offers a comprehensive suite of services for the development of Streptococcus dentisani as probiotics, including identification and characterization of strain-specific features, genomic sequencing, and functional analysis. These services aim to optimize the therapeutic potential of Streptococcus dentisani for specific oral health conditions, ensuring high efficacy and safety standards in probiotic formulation.
Can Creative Biolabs customize Streptococcus dentisani strains for specific research needs?
Yes, Creative Biolabs is capable of customizing Streptococcus dentisani strains to meet specific research needs. This includes genetic modifications to enhance beneficial traits, adaptation to different oral environments, and tailoring the bacteria for targeted preventive or therapeutic actions against specific pathogens or conditions.
Resources
References
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López-López, Arantxa, et al. "Health-associated niche inhabitants as oral probiotics: the case of Streptococcus dentisani." Frontiers in microbiology 8 (2017): 379.
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Distributed Under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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