Lactobacillus acidophilus as Next Generation Probiotics

Health benefits of Lactobacillus acidophilus (L. acidophilus) include providing immune support for infection or cancer, reducing the occurrence of diarrhea in humans, helping to lower cholesterol, and improving lactose intolerance symptoms. L. acidophilus can be a good candidate for live biotherapeutic products (LBP). Creative Biolabs offers well-established and innovative One-Stop-Shop LBP solutions. We will find a way to manage both the entire supply chain and the value chain to meet your needs.

Introduction of L. acidphilus

L. acidophilus was originally isolated from the human gastrointestinal tract (baby feces). Isolated strains of L. acidophilusare also part of the natural human microbiota and have been cultivated from the mouth, digestive system, and vaginal area. L. acidophilus is a short (2-10μm), Gram-positive bacillus that grows optimally from 37 to 42℃ and can develop at temperatures as high as 45℃. The maximum growth rate was reached at pH 5.5~6.0, and the growth stopped at pH 4.0. L. acidophilus is an obligate homofermentative organism that ferments carbohydrates to produce lactic acid and is one of the least aerobic lactic acid bacteria.

Cell wall structure of <em>L. acidophilus</em>. Fig.1 Cell wall structure of L. acidophilus. (Jafarei, 2011)

L. acidophilus for Disease Treatment

To investigate the inhibitory effect of probiotics on the progression of hepatocellular carcinoma and colorectal cancer, Bulb/C mice were selected as experimental subjects to study the genes involved in carcinogenesis. The results showed that Azoxymethane induced the expressions of miR-221, miR-155, Bcl-W, and KRAS in blood, decreased the expressions of miR-122, PTEN and PU1 in blood, but had no effect on miR-18a in the liver tissue. Probiotic consumption enhanced the significant overexpression of miR-122, and PU1 (in blood) and the significant downregulation of miR-221 and miR-155 (in blood). Thus, the probiotics can help to control cancer progression by postponing of metastasis process, reducing inflammation, and down and up-regulation of oncogenes/oncomirs and tumor suppressor genes/microRNAs, respectively.

A schematic of used methods and results of the work. (Heydari, 2019) Fig.2 A schematic of used methods and results of the work. (Heydari, 2019)

IBD is an important immune-related disease, that can occur through immune system malfunction originating due to dysregulation of the gut microbiota. Scientists investigated the capabilities and mechanisms of L. acidophilus KBL402 and KBL409 treatment in the alleviation of colitis using the in vivo dextran sodium sulfate (DSS)-induced colitis mice model. L. acidophilus treatment could restore the diversity of the gut microbiota. Mice with L. acidophilus KBL402 treatment showed a high relative abundance of the genus Akkermansia and Prevotella. Butyrate and propionate, the major short-chain fatty acids, in the ceca of DSS+KBL402-treated mice were significantly higher than in that of the mice with DSS-induced colitis. This study suggested that L. acidophilus KBL402 and KBL409 could prevent or treat IBD through multiple pathways, including regulating immune response and miR-expression, restoring intestinal flora, and metabolite production.

Differences in cecal microbiota using <em>L. acidophilus</em> administration. (Kim, 2021) Fig.3 Differences in cecal microbiota using L. acidophilus administration. (Kim, 2021)

What Services Can We Provide for L. acidophilus at Creative Biolabs?

L. acidophilus Related Products at Creative Biolabs

  • Strain Products

We supply a variety of L. acidophilus strains of different preservation numbers as below. If you need other strains, please contact us.

CAT Product Name Product Overview
LBP-003CYG Lactobacillus acidophilus Powder Freeze-dried L. acidophilus powder.
LBST-137FG Lactobacillus acidophilus; 138598 L. acidophilus is a species of Gram-positive bacteria in the genus Lactobacillus. It is a homofermentative, microaerophilic species, fermenting sugars into lactic acid, and grows readily at rather low pH values.
LBST-138FG Lactobacillus acidophilus; 186470 L. acidophilus was isolated from human intestinal. It is a species of Gram-positive bacteria in the genus Lactobacillus. L. acidophilus is a homofermentative, microaerophilic species, fermenting sugars into lactic acid, and grows readily at rather low pH values; below pH 5.0 and has an optimum growth temperature of around 37°C.
  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs is flexible to meet the unique needs of LBP client projects. We can apply our considerable experience to develop the necessary analytics specific to your project. If you are interested in our L. acidophilus related products and services, please contact us for more.

References

  1. Jafarei, P.; Ebrahimi, M.T. Lactobacillus acidophilus cell structure and application. African Journal of Microbiology Research. 2011, 5(24): 4033-4042.
  2. Heydari, Z.; et al. Different anti-inflammatory effects of Lactobacillus acidophilus and Bifidobactrum bifidioum in hepatocellular carcinoma cancer mouse through impact on microRNAs and their target genes. Journal of Nutrition & Intermediary Metabolism. 2019, 16: 100096.
  3. Kim, W.K.; et al. Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice. Food & Function. 2021, 12(1): 340-350.

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