Since its original isolation, evidence is growing to support the significance of strains belonging to Anaerostipes hadrus (A. hadrus) within the human GI tract. Creative Biolabs is a CRO company focused on live biotherapeutic products (LBP) development, we offer our technical expertise and experience to provide traceable, customizable solutions.
A. hadrus has been estimated to represent 2% of the total microbiota in a healthy human colon. Anaerostipes hadrus is a Gram-positive bacterium from the genus of Anaerostipes which has been isolated from human faeces. The cells are rods, non-motile, and are approximately 3×0.5 μm in size. Endospores were not observed. Anaerostipes hadrus is a bacterium known for its ability to produce butyric acid. Butyrate has been shown to have a positive effect on gastrointestinal homeostasis because it promotes intestinal epithelial cell growth, increases tight junction protein expression, and acts as an anti-inflammatory agent. Therefore, butyrate-producing bacteria are generally considered to promote health.
Research on gut microbiota genomic structural variants (SVs) uncovered that a region in A. hadrus that encodes a composite inositol catabolism-butyrate biosynthesis pathway is associated with low host metabolic risk assessed by BMI, waist-to-hip ratio, etc.
A. hadrus-like bacteria were found to be more abundant in the feces of healthy controls in our study concerning diarrhea-predominant IBS. The study was based on high-throughput 16S rRNA gene sequencing, and the health-associated phylotype was referred to as Ruminococcus torques phylotype 93%. A. hadrus-like bacteria were present also in IBS subjects but in significantly lower numbers than healthy controls.
We supply a variety of A. hadrus strains of different preservation numbers as below. If you need other strains, please contact us.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.