Anaerostipes hadrus as Next Generation Probiotics

Since its original isolation, evidence is growing to support the significance of strains belonging to Anaerostipes hadrus (A. hadrus) within the human GI tract. Creative Biolabs is a CRO company focused on live biotherapeutic products (LBP) development, we offer our technical expertise and experience to provide traceable, customizable solutions.

Introduction of A. hadrus

A. hadrus has been estimated to represent 2% of the total microbiota in a healthy human colon. Anaerostipes hadrus is a Gram-positive bacterium from the genus of Anaerostipes which has been isolated from human faeces. The cells are rods, non-motile, and are approximately 3×0.5 μm in size. Endospores were not observed. Anaerostipes hadrus is a bacterium known for its ability to produce butyric acid. Butyrate has been shown to have a positive effect on gastrointestinal homeostasis because it promotes intestinal epithelial cell growth, increases tight junction protein expression, and acts as an anti-inflammatory agent. Therefore, butyrate-producing bacteria are generally considered to promote health.

The Benefit of A. hadrus

  • Reduce Metabolic Risk

Research on gut microbiota genomic structural variants (SVs) uncovered that a region in A. hadrus that encodes a composite inositol catabolism-butyrate biosynthesis pathway is associated with low host metabolic risk assessed by BMI, waist-to-hip ratio, etc.

  • Irritable Bowel Syndrome (IBS)

A. hadrus-like bacteria were found to be more abundant in the feces of healthy controls in our study concerning diarrhea-predominant IBS. The study was based on high-throughput 16S rRNA gene sequencing, and the health-associated phylotype was referred to as Ruminococcus torques phylotype 93%. A. hadrus-like bacteria were present also in IBS subjects but in significantly lower numbers than healthy controls.

What Services Can We Provide for A. hadrus at Creative Biolabs?

A. hadrus Related Products at Creative Biolabs

  • Strain Products

We supply a variety of A. hadrus strains of different preservation numbers as below. If you need other strains, please contact us.

  • Customized strain culture supernatant. (e.g.: for animal research)
  • Customized strain lyophilized powder containing certain CFU. (e.g.: for animal research)

Creative Biolabs has been chosen by our big pharmaceutical and biotechnology clients for our expertise, affordable development services, reliable results, and fast turnaround times. Please feel free to contact us, we welcome the opportunity to discuss the ways we can work with you to drive your project.

Reference

  1. Allen, V.E.; et al. Anaerostipes hadrus comb. nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976. Anaerobe. 2012, 18(5): 523-529.

For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.

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