Lactobacillus rhamnosus as Next Generation Probiotics
Lactobacillus rhamnosus is a well-characterized bacterium displaying great probiotic potential in a diversity of therapeutic areas. Creative Biolabs, a world-leading services provider in drug discovery, is dedicated to providing a full range of probiotic products and fast services for our worldwide customers.
Introduction to Lactobacillus rhamnosus
Lactobacillus rhamnosus a strain of Lactobacillus rhamnosus (L. rhamnosus) species, is one of the most widely researched probiotic bacteria isolated from the intestinal tract of healthy individuals in 1983. It is a member of the genus of Lactobacillus and the family of Lactobacillaceae. Bacteriologically, the strain is a Gram-positive bacterium with rod shape and good adhesion to intestinal epithelial cells. When cultured, the strain usually forms creamy white colonies with a distinct buttery smell.
the strain is a well-documented probiotic strain with good resistance to acid and bile and the highest binding capacities among the Lactobacillus. A variety of commercial products based on the strain has been explored and developed, including food, dietary supplements, and therapeutic drugs, many of which are extensively investigated in numerous clinical trials for the effective treatment of human diseases.
Fig.1 Phenotypic characteristics of Lactobacillus rhamnosus.1
Probiotic Properties of Lactobacillus rhamnosus
As one of the most characterized and utilized probiotics, the strain has been shown great benefits for the treatment of a variety of human diseases through several mechanisms.
The excellent adhesion properties to the intestinal mucosa and survival in a broad pH range and bile salts make the strain easier to colonize the intestine to function beneficial effects. Worldwide trials indicate that intestinal the strain exhibits effective prevention and treatment of diarrhea both in children and adults, including rotavirus-caused acute diarrhea and antibiotic-associated diarrhea. And the strain supplement has been demonstrated to prevent clostridium difficile infections.
The immune regulation effects of the strain have been extensively researched through the enhancement of the cellular immune response, anti-inflammatory response, and gut defense. All these immune-regulatory properties endow the strain great potential for the applications of pathogen prevention, allergic diseases treatment, and vaccination as a probiotic adjuvant.
Animal studies have revealed that the strain could prevent tumorigenesis by inducing tumor cell apoptosis, inhibiting the expression of angiogenesis and inflammation in colon cancer rates.
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Other beneficial potential
the strain has been widely evaluated as a promising probiotic bacterium in many other activities and treatments, such as intestinal microbiome alteration, anti-obesity, insulin sensitivity increase, depression and anxiety alleviation, inflammatory bowel disease, and dental health care.
Creative Biolabs has invested numerous energy and efforts in the development of Next-Generation probiotics for the various diseases therapy. We now provide a comprehensive range of products and services for the development of L. rhamnosus-based live biotherapeutic.
For any questions, please directly contact us for more details.
References
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Segers, Marijke E., and Sarah Lebeer. "Towards a better understanding of Lactobacillus rhamnosus host interactions." Microbial cell factories 13.Suppl 1 (2014): S7.
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Distributed Under Open Access license CC BY 4.0, without modification.
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For Research Use Only. Not intended for use in food manufacturing or medical procedures (diagnostics or therapeutics). Do Not Use in Humans.
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